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At least 19 recordsLinked to original sources
PubMedDate not supplied

Avian influenza (bird flu) and dentistry. Interview by Nelson L. Rhodus.

Now is the time for dental health care professionals to plan and prepare for their response to a potential pandemic. All dental health care professionals should be vaccinated. Dentists should engage their entire practice teams in those discussions and contingencies. Dentists should become familiar with the national public health plan and comply with it. Dentists should be prepared for an illness in which the principles of prioritization of treatment, including deferring routine care and/or suspending care, might be needed. Dentists should obtain and provide accurate information and should not allow themselves to be swayed by media hype.

Animals↗
PubMed2006

Influenza ("Bird Flu"), inflammation and anti-inflammatory/analgesic drugs.

The spectre of an influenza pandemic is being widely mooted. Most of the strategies explored to date for controlling or treating the condition have centred on controlling the spread of the infection, the use of vaccines or anti-viral agents. There has been relatively little discussion about treating the lung and systemic inflammatory reactions that occur during influenza infection. In this review a range of therapeutic agents are proposed to treat the inflammatory reactions, principally in the lung as well as the systemic cytokine-mediated immuno-inflammatory reactions that may be a major cause of the morbidity and mortality associated with influenza infections. Among these are pentoxifylline, the statins, the macrolide antibiotics (e.g. azithromycin, clarithromycin, erythromycin), resveratrol (a component of wine and fruits with inhibitory effects on influenza virus replication) and nutraceuticals (including those that contain flavonoids, the marine oils eicosapentanoic and docosanoic acids or the green-lipped mussel extract, Liprinol which may by virtue of the inhibitory effects on the production or actions of pro-inflammatory cytokines, be useful for their anti-inflammatory actions. The efficacy, mode of actions and side effects of non-steroidal anti-inflammatory drugs (NSAIDs) are considered. There are a number of issues relating to their use in treating the inflammatory reactions in the respiratory tract. Among these are the development of gastro-intestinal ulcers and bleeding and hepato-renal reactions in patients that may because of severe systemic inflammation be prone to the development of these adverse reactions. There are also theoretical issues concerning the impact of COX-1 mediating reduction in prostaglandin and increased cytokine production that might have some negative consequences for respiratory inflammation.In conclusion, further consideration should be given to exploring the actions of these anti-inflammatory agents to control the respiratory inflammatory in influenza infections which can have serious consequences for the outcome of the infection.

Animals↗
PubMedDate not supplied

[Gene analysis and phenotypic characteristic of highly-reproductive reassortants, containing the gene for bird influenza virus subtype H2 hemagglutinin].

A series of reassortant clones with antigenic formulae H2N1 and H2N3 were produced by genetic reassortment performed with the use of an avian influenza virus, A/Pintail Duck/Primorie/695/76 (H2N3) and a high-yield reassortant strain X-67. Preliminary identification of the parent origin of NP and NS genes for 5 reassortants was performed by comparison of the mobilities of virus-specific proteins in polyacrylamide gel electrophoresis. The parent origin of genes of internal and nonstructural proteins for 3 reassortants was identified by partial sequencing. Although the genes of internal and nonstructural proteins of the reassortants originated from high-yield X-67 virus, only H2N3 reassortants were similar to the high-yield parent virus as concerns the level of the virus accumulation evaluated by hemagglutination titration and measurement of the virus protein content.

Animals↗
PubMed2005

Standardization of a duplex RT-PCR for the detection of Influenza A and Newcastle disease viruses in migratory birds.

Influenza A and Newcastle disease viruses are pathogens of social and economical importance known to be disseminated throughout the world by migratory birds. Many efforts have been made to control the introduction of these viruses into new environments, and complete world surveillance has yet to be achieved. Virus isolation and immunofluorescence techniques are time consuming, have inherent limited sensitivity and present a lack of host cells permissive universally to all Influenza A viruses. In this paper, the use of a duplex RT-PCR is described capable of sorting out any NDV and Influenza A virus strain simultaneously in oral and cloacal swab specimens. This method includes fluorescent detection of amplicons that provide accurate analysis of many DNA fragments within one base discrimination. Reference viruses were used for standardization of the assay and samples from wild-type viruses were screened, with four positive results for Influenza A detected in migratory birds captured in the state of Sao Paulo. This screening test can be considered a first step for further studies of these viruses circulating in avian species in Brazil, and hopefully will contribute to broaden the sample spectrum from wild birds, leading to a better understanding of these viruses and their participation in the southeastern region of the country.

Animals↗
PubMedDate not supplied

The risk of avian influenza in birds in Australia.

Avian influenza viruses may cause mild or severe disease in birds. There have been five recorded outbreaks of highly pathogenic avian influenza in birds in Australia, all of which were caused by the H7 subtype. These were quickly controlled and similar coordinated responses are expected for possible future outbreaks of avian influenza. Migratory birds are not regarded as the source of these outbreaks, and the prevalence of avian influenza viruses in wild birds in Australia is very low. Avian influenza H5N1, which emerged in birds in China in 1996, has spread to bird flocks in Asia, Europe and Africa. The main carriers of avian influenza, ducks, do not migrate to Australia, and currently the risk of H5N1 occurring in Australian birds appears to be low. Nevertheless, surveillance and response plans for outbreaks of highly pathogenic avian influenza have recently been upgraded across Australia.

Animal Migration↗
PubMed2006

In silico analysis of genes nucleoprotein, neuraminidase and hemagglutinin: a comparative study on different strains of influenza A (Bird flu) virus sub-type H5N1.

The avian influenza (bird flu) is an infectious disease of birds, ranging from a mild to a severe form of illness. Influenza viruses pose significant challenges to both human and animal health. The proteins, nucleoprotein (NP), neuraminidase (NA) and hemagglutinin (HA) of influenza A virus (Bird flu virus) sub-type A/Hatay/2004/(H5N1) from chicken were selected for this study. Our in silico analysis predicted that HA of influenza A virus is highly sensitive to mutations and hence it is significant for its pathogenic nature. None of the mutations was detected as an important change except in NA where K332R was at a PKC phosphorylation site. Analysis of the sequence comparison showed that the maximum number of mutations were observed in HA. These mutations are significant as they are involved in change in polarity or hydrophobicity as well as in propensity of each amino acid residue to stabilize the secondary structure. The program MAPMUTATION can be used to monitor the mutations, and predict the trend of mutations.

Amino Acid Sequence↗
PubMedDate not supplied

[Surveillance and control measures of avian influenza in birds. Implications for public health].

Avian influenza is an infectious disease that mainly affects birds, caused by influenza A type viruses, in most cases of low pathogenecity. Rapid mutations of these viruses to highly pathogenic forms represent a serious risk for animal and public health. Since 2003, an outbreak of highly pathogenic avian influenza in birds is taking place with transmission and resulting illness in humans and which is believed to be able to start a human influenza pandemic. To face these outbreaks, a joint effort between the animal and public health sector is needed to identify areas affected by animal disease and to intensify surveillance of human cases in them. Control measures in animals must be compatible with risk reduction of human exposure. The aim of this article is to review the general control measures developed against avian influenza in birds, highlighting coordination and communication aspects between Animal Health and Public Health, taking into account that legislation is constantly being updated as the dynamic of the disease changes.

Animal Husbandry↗