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Results for “ISONIAZID/metabolism”

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At least 19 recordsLinked to original sources
PubMed1960

The accumulation of isoniazid in tissues, and the course of experimental tuberculosis.

In an attempt to find agents enhancing the infiltration of isoniazid into tissues, the authors have investigated the effect of the drug on oedema due to injection of egg white into the rat paw, when it was given alone and in conjunction with histamine, antazoline, carbachol, chlorpromazine, and a pyrogen. Isoniazid increased the oedema. All the substances, except antazoline, increased the rate at which isoniazid disappeared from the blood, and they all favoured accumulation of the drug in tissues. Treatment of experimental tuberculosis with subthreshold doses of isoniazid, in conjunction with the above compounds, gave better results than when isoniazid was used alone.

Animals↗
PubMed1961

Genetical and geographic studies on isoniazid inactivation.

Rapid and slow inactivators of isoniazid are homozygotes, and intermediate inactivators are heterozygotes. There is no dominance between the two alleles. The chasm between Eskimos and Caucasians in isoniazid metabolism is bridged by our investigation of the races in the Far East.

Alleles↗