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Results for “IRON, RADIOACTIVE”

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At least 19 recordsLinked to original sources
PubMed1975

[Study of anemia in spirochetosis of poultry by means of radioactive iron].

Radioactive iron was used to follow up some hematologic indices in birds infected with irradiated spirochetes of the Borrelia anderina species. Used were a total of 90 cockerels, aged two months, divided into three groups. Ist group - cockerels inoculated with spirochetes that had been gamma-irradiated at the rate of 40000 R; IInd group-cockerels inoculated with untreated spirochetes; and IIIrd group - normal cockerels. The infective material consisted of strain Rouen spirochetes of the Pamoukchii serotype. Radiometric studies were also carried out to find out to what extent radioactive iron was incorporated in the erythrocytes and was deposited in the liver, spleen, and marrow of the investigated birds. Classical methods of investigation were employed to determine the erythrocyte, leukocyte, and thrombocyte counts, the hemoglobin content (after Sahli) as well as the erythrocyte pack after the method of Todorov. It was found that the inoculation of gamma-treated spirochetes led to sub-clinical changes in the hemopoiesis of the cockerels. Such changes, however, were negligible and were rapidly overcome by the birds. So they could successively be referred to in the specific immunoprophylaxis of spirochetosis. 59FeCl3 can be successfully applied in the study of anemia in birds caused by sbirochetosis.

Anemia↗
PubMed1950

Age as effecting the osmotic and mechanical fragility of dog erythrocytes tagged with radioactive iron.

Radioactive iron was administered to three normal dogs, two of which had previously been bled, in order to tag a group of erythrocytes of approximately known age. The osmotic fragility of the newly formed tagged cells was significantly greater than that of the general cell population during the first few days after injection of the iron, while the mechanical fragility of the young cells was less than that of the general red cell population. As the cells aged and approached the end of their life span, their susceptibility to destruction by trauma inflicted by rolling glass beads exceeded that of the general cell population. The osmotic behavior of the old cells was not distinctive. The increased mechanical fragility of senescent cells suggests that the life span of erythrocytes may be limited at least in part by changes within the cell which render it more susceptible to destruction by mechanical wear and tear in the circulation. It is emphasized, however, that the trauma produced by rolling glass beads may be quite unlike that inflicted upon red cells in vivo. A decrease in circulating radioactive iron was observed in each experiment soon after the mechanical fragility of the tagged cells began to exceed that of the total cell population. The lowest point on the curve representing circulating radioiron was noted at 119, 119, and 122 days respectively after injection of iron in the three experiments. Estimates of the life span of dog erythrocytes obtained in this way agree with those provided by other methods.

Age Factors↗
PubMed1968

Method for the determination of unsaturated iron-binding capacity of serum using radioactive iron and magnesium carbonate.

A method for measuring the unsaturated iron-binding capacity of serum using radioactive iron with magnesium carbonate as the adsorbing substance is described. The radioactive iron-magnesium carbonate method, compared with the methods of Caraway (1963), Herbert, Gottlieb, Lau, Fisher, Grevirtz, and Wasserman (1966), and Bothwell, Jacobs, and Kamener (1959), was shorter and simpler and equally reproducible.

Adsorption↗
PubMed1969

Semi-automated micromethod for estimating the unsaturated iron-binding capacity of serum using radioactive iron.

A semi-automated micromethod for the determination of the unsaturated iron-binding capacity (UIBC) of serum using radioactive iron and magnesium carbonate as an adsorbing substance is presented. The method has the advantage of simplicity and speed. The determination of UIBC is carried out on 0.1 ml of serum in duplicate, using autodiluters, at the rate of up to 200 sera per day. The reproducibility of the presented method is comparable to the reproducibility of other methods for the determination of iron-binding capacity. As the method is a simple one it can easily be introduced into laboratories with facilities for radioactive counting.

Autoanalysis↗