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At least 19 recordsLinked to original sources

[Design of a thermic detection system applied to chick embryonated eggs irradiated with infrared rays].

Infrared radiations are widely used in medical therapeutics. It has been argued that the doses and the periods of time employed in experimental animals are higher than those used in clinic. Thus, we considered of interest to analyse aspects of dosimetry and thermic effects of infrared rays with current methods in medical practice, using the in ovo chick embryo as a model of easy control. To this end we designed a system to measure temperatures and their acquisitions and software for its handling. The system consists of: a) thermic points: thermocuples or termistores adaptable to the experimental requirements and calibrated with a greater precision within a range of ten degrees around the incubation temperature; b) acquirer circuit of thermic data (hardware): it generates a time base that varies with the thermic sensor. Software: the PC XT or AT detects changes in the time base by means of a programs' in a Turbo Pascal; c) storage and analysis of data allows, through a menu (expansibles) the scale selection, time of program data to be acquired, storage and recovery of the diskette information and graphic impression; d) chick's embryonated eggs. This system allows to measure temperature distribution in small physical spaces with little disturbance of the system to be measured in irradiated bodies, to analyse variations of the temperatures in time and to secure a greater confidence and automatism to obtain the required data.

Animals↗

Hyperthermic treatment of sporotrichosis: experimental use of infrared and far infrared rays.

We used pocket warmers and infrared and far infrared rays to treat 14 cases of sporotrichosis, 7 in children and 7 in adults. There were 9 cases of the fixed cutaneous type and 5 of the lymphocutaneous type; 6 were located on the face and 8 on the limbs. Four cases were treated with pocket warmers, 5 with infrared rays, and 5 with far infrared rays. All lesions treated with pocket warmers were facial lesions in children; infrared and far infrared ray treatments were used in 3 children and 7 adults, 2 on facial lesions and 8 on lesions on the extremities. In treatments with infrared and far infrared rays, the amount of heat was greater than with the pocket warmers, and one 15-min treatment daily was sufficient to yield satisfactory results, but this method is difficult to use on children and on the face, and 40-min treatments two or three times a week proved unsatisfactory. Infrared and far infrared ray treatments allow the length of a single treatment to be reduced by three-quarters, in comparison with one pocket warmer treatment.

Adult↗

Investigation of jewelry powders radiating far-infrared rays and the biological effects on human skin.

Far-infrared rays have certain kinds of effects on the human body, especially on skin, blood circulation, and skin cell vitalizing. Some jewelry powders radiate far-infrared rays. Jade has powerful far-infrared ray radiation, and tourmaline has pyroelectric and piezoelectric properties and radiated far-infrared rays. The jewelry powders (fine powdered jade and tourmaline powders) were screened by far-infrared rays for radiation properties and tested for the effects of far-infrared rays on the human skin by temperature observation using an infrared thermal analyzer.

Adult↗

Effect of linear polarized near-infrared ray irradiation on the chemiluminescence of human neutrophils and serum opsonic activity.

The purpose of this study was to investigate the in vitro effects of linear polarized near-infrared ray irradiation on neutrophil chemiluminescence (CL) and serum opsonic activity. We used luminol- and lucigenin-dependent CL to detect the affected reactive oxygen species production process of human neutrophils and measured serum opsonic activity based on luminol-dependent CL. The linear polarized near-infrared ray irradiation suppressed a maximum light emission (peak height) of luminol- and lucigenin-dependent CL in a dose-dependent manner. The findings suggested that the linear polarized near-infrared ray irradiation suppressed the superoxide anion and hypochlorite production of human neutrophils. The serum opsonic activity was decreased by linear polarized near-infrared ray irradiation, and this suppressive effect might be caused by inhibiting the activation of the classical and alternative complement pathway. Therefore, it is suggested that near-infrared ray irradiation may have an inhibitory effect against chronic pain via reduction of reactive oxygen species production and opsonic activity.

Acridines↗

[Clinical significance of diagnosis of varicocele with infrared ray imaging].

OBJECTIVE: To investigate the temperature change of scrotum caused by varicocele(VC) and its significance. METHODS: One hundred and sixty-six VC patients were examined by infrared ray imaging and colored ultrasonic scanning, and the results were analyzed. Comparisons of the infrared ray images and the routine semen analysis of 106 of the patients were made between before and after the operation. RESULTS: The difference in the infrared ray images between before and after the operation on the VC patients was significant (P < 0.01), and so was the difference in the results of semen analysis(P < 0.01; some of the items P < 0.05). CONCLUSIONS: The infrared ray imaging, together with the semen analysis and colored ultrasonic scanning, had a directive value for the diagnosis and treatment of VC patients.

Adolescent↗

[Research and application of far-infrared rays to drying Chinese medicinal herbs in small pieces].

OBJECTIVE: To introduce a far-infrared ray dryings device. METHOD: The research background, work tenets, structure, function, technical parameters and tentative application of the device were reported. Chinese medicinal herbs in small pieces which contain volatile oils were dried by far-infrared rays and airing. The two drying methods were compared. RESULT AND CONCLUSION: Not degrading the quality of medicinal herbs in small pieces, the device can be used to dry various kinds of medicinal herb pieces and thus deserves popularization.

Infrared Rays↗

[Cerebral oxygenation and near-infrared rays spectrophotometry].

Near infrared spectroscopy (NIRS) is a new technique which allows non invasive bedside monitoring of cerebral oxygenation and hemodynamics by measuring relative changes in cerebral oxy- and deoxyhaemoglobin and cytochrome aa3. We have applied this technique to evaluate the possible effects on cerebral oxygenation and hemodynamics of clinical procedures usually performed on preterm infants:--endotracheal suctioning, and we have demonstrated that the magnitude and the duration of the negative effects of open system are significantly reduced using closed endotracheal suctioning system;--withdrawal and infusion through umbilical vein and artery cause significant changes in cerebral hemodynamics: these effects are significantly reduced after administration of ibuprofen;--treatment of patent ductus arteriosus with ibuprofen does not significantly reduce cerebral perfusion and oxygen availability compared to indomethacin and ibuprofen administration also does not affect cerebral vasoreactivity to arterial carbon dioxide tension;--administration of different types and doses of natural surfactant causes different changes in cerebral hemodynamics and these effects seem to be dose-related. Therefore NIRS is an useful device to investigate cerebral oxygenation state of preterm infants and new possibilities could derive from the introduction of a new NIRS method which allows to measure the tissue oxygenation index.

Blood Transfusion↗

[The effect of far infrared rays on the survival of randomized skin flap in the rat: an experimental study].

In order to observe the effect of far infrared rays on the survival of skin flap, the following experiment was performed. Forty-eight SD rats were selected and divided into two groups. The rats received 0.3 w/cm2 radiation twice a day from 3 days before operation to 5 days after operation in the experimental group, while in the control group the rats received none before or after the operation. The flap was designed as 2 cm x 6 cm in the back of the rats with the pedicle caudalward. The microcirculatory changes of the flap were observed, and the survival area of the flap was calculated. The results showed that either in the proximal or in the distal part of the graft, in the experimental group, the mean opening rate, diameter and the flowing velocity of the microvessels were significantly higher than those in the control group (P < 0. 05). The mean rate of survival area of the experimental group (80.5%) was also higher than that of the control group (62.7%) (P < 0.01). It was suggested that radiation with far infrared rays could dilate the microvessels, improve the flap microcirculation, therefore, enhance the survival of the randomized skin flap.

Animals↗

An investigation of an infrared ray electronic endoscope with a laser diode light source.

An infrared ray electronic video-endoscope with a laser diode light source was used to obtain information on the submucosal area. As contrast medium we employed indocyanine green, which has a light absorption peak in the infrared range. The wavelength of the laser diode was set to 810 nm as suggested by the results of the spectrophotometric study on the reflected light at fingertips after injection of ICG (3 mg/kg). Using this system we inspected the stomach under visible light and then continuously under infrared light before and after intravenous injection of ICG (2 mg/kg). A dendritic figure with fine ramifications emerged in the early stage after intravenous injection of indocyanine green, which was not seen under visible light. These features of the figure visualized by the infrared endoscope suggest that they have a close relationship with blood vessels and blood circulation beneath the mucosal surface. This infrared electronic endoscope system provides submucosal information more readily and at a lower cost than ever before, and also the infrared lighting method of this system could be applied to almost all available electronic endoscopes by modulating infrared cutting filters, so it could become a valuable clinical tool.

Electronics, Medical↗

Labeled carcinoembryonic antigen antibodies excitable by infrared rays: a novel diagnostic method for micro cancers in the digestive tract.

OBJECT: An indocyanine green derivative (ICG-sulfo-OSu) was used as the labeling substance for monoclonal antibody, and a fluorescence imaging system appropriate for ICG-sulfo-OSu excitable by infrared rays (IR) was developed. The goal of this study was to demonstrate antibody labeling at the tissue level using this new imaging system. MATERIALS AND METHODS: ICG-sulfo-OSu labeled mouse anti-human carcinoembryonic antigen (CEA) monoclonal antibody, a newly developed imaging system, and an infrared ray microscope were employed in this experiment. Paraffin sections of human colon cancer previously proven to have cross-reactivity to anti-CEA antibody were examined. RESULTS: Positive staining was seen as a brownish discoloration of oxidized 3,3'-diaminobenzidine tetrahydrochloride (DAB) in sections that reacted with ICG-sulfo-OSu-labeled anti-CEA antibody, and the fluorescence was well-matched with the oxidized DAB-positive sites. CONCLUSION: Specific antibodies labeled with ICG-sulfo-OSu have significant affinity to cancer cells and seem to reflect sufficient amounts of fluorescence by IR to be useful in a system for the endoscopic detection of micro cancers using the immunohistochemical staining method.

Adenocarcinoma↗

Evidence that irradiation of far-infrared rays inhibits mammary tumour growth in SHN mice.

To evaluate the effect of irradiation of far infrared rays (FIR), the growth of spontaneous mammary tumours of SHN mice was compared among 3 groups: the control was kept until the end of experiment on the normal rack in the absence of FIR and Experimental group I was constantly exposed to FIR. Experimental group Il was raised as the control followed by movement to the FIR rack after mammary tumour appearance. While there was little difference between the control and Experimental group I in mammary tumour growth for 16 days, Experimental group II was significantly lower than the control in this parameter. Furthermore, the percentage of rapidly growing tumours showing greater than 200% of growth rate was apparently lower in Experimental group II. Associated with this, epidermal growth factor receptor expression in mammary tumours, anterior pituitary weight and serum leptin level were significantly decreased in Experimental group II. The findings suggest that whole-body FIR irradiation at ambient temperature could be a possible way of a hyperthermic therapy for tumours.

Animals↗

Promotive effects of far-infrared ray on full-thickness skin wound healing in rats.

The biological effects of far-infrared ray (FIR) on whole organisms remain poorly understood. The aim of our study was to investigate not only the hyperthermic effect of the FIR irradiation, but also the biological effects of FIR on wound healing. To evaluate the effect of FIR on a skin wound site, the speed of full-thickness skin wound healing was compared among groups with and without FIR using a rat model. We measured the skin wound area, skin blood flow, and skin temperature before and during FIR irradiation, and we performed histological inspection. Wound healing was significantly more rapid with than without FIR. Skin blood flow and skin temperature did not change significantly before or during FIR irradiation. Histological findings revealed greater collagen regeneration and infiltration of fibroblasts that expressed transforming growth factor-beta1 (TGF-beta1) in wounds in the FIR group than in the group without FIR. Stimulation of the secretion of TGF-beta1 or the activation of fibroblasts may be considered as a possible mechanisms for the promotive effect of FIR on wound healing independent of skin blood flow and skin temperature.

Animals↗