The syndrome of familial juvenile hypoadrenocorticism, hypoparathyroidism and superficial moniliasis.
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Hypoadrenocorticism was diagnosed in four related leonbergers. Two of the four dogs also had low-resting serum thyroxine (T4) levels and signs consistent with hypothyroidism. The familial association of the affected dogs and the presence of coexisting thyroid dysfunction are similar to what is seen in human type II polyglandular autoimmune syndrome.
Thirty-one ancestors of a Standard Poodle with hypoadrenocorticism were located. Hypoadrenocorticism had been confirmed in 8 of 32 dogs (25%) by use of ACTH response testing or necropsy. In 2 additional dogs, hypoadrenocorticism was diagnosed on the basis of characteristic clinical signs and serum electrolyte abnormalities consistent with adrenocortical insufficiency. Although an obvious pattern of inheritance was not evident, the high prevalence of hypoadrenocorticism suggested that heredity may have been a factor in the development of idiopathic adrenal insufficiency in dogs of this family.
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