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Results for “HLA-A1 Antigen”

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At least 19 recordsLinked to original sources
PubMed1978

[IgA-immunoglobulins and HLA-A1 antigen in Wilms' tumor. Significance for the prognosis of the disease].

In 45 patients with Wilms' tumor of the kidney the IgG, IgA, and IgM serum immunoglobulin levels were quantitated and 23 antigens of HLA-A and HLA-B locues were typed on the same patients' lymphocytes. In 22 individuals with increased IgA immunoglobulin level a more frequent incidence of HLA-A 1 antigen was found. This antigen was established in 62.5% of patients with IgA levels higher than 200 IU/ml. Considering the fact that 86.35% of the patients survive two years, and 16 of 22 patients (= 72.72%) are practically cured, it is suggested that the simultaneous occurrence of increased levels of IgA immunoglobulin and of HLA antigen A 1, is a favourable prognostic sign.

Adolescent↗
PubMed1979

Absence of allogeneic restriction in human T-cell-mediated cytotoxicity to Epstein-Barr virus-infected target cells. Demonstration of an HLA-linked control at the effector level.

Peripheral T lymphocytes from patients with infectious mononucleosis (IM) are sensitized in vivo against the Epstein-Barr virus (EBV). The expression of HLA-A, B, or C molecules at the target cell surface is necessary for the cytotoxic reaction because (a) EBV-positive Daudi cells lacking HLA-A, B, and C determinants are resistant to anti-EBV T-cell lysis, (b) cytolysis of EBV-positive target cells can be consistently inhibited by anti-HLA-A, B, and C and anti-beta 2 microglobulin antibodies. However, no evidence for allogeneic restriction in this system was apparent as (a) cytotoxic T lymphocytes (CTL) from one given individual could exert a cytotoxicity of a similar magnitude on different EBV-positive target cells, regardless of the number of HLA-A or B specificities shared by the effectors and targets; (b) CTL from IM patients were able to kill target cells without any HLA-A or B antigen in common; and (c) T5-1 variants lacking one or two HLA antigens at the A, B, or D locus are killed to the same extent as the parental cells. 7 of the 9 IM patients with detectable circulating anti-EBV CTL carried the HLA-A1 antigen, whereas none of the 16 IM patients lacking detectable peripheral CTL were HLA-A1 positive (mean specific lysis of T5-1 target cells by T cells from HLA-A1 positive patients: 29.3 vs. 0.6% in HLA-A1-negative patients) (P less than 10(-9)). These data suggest an HLA-A1-linked gene control of the magnitude of the anti-EBV CTL response. Thus, the HLA region appears to act at two different level sin the T-cell-mediated lysis of EBV-infected cells by controlling first, the development of anti-EBV and second, the expression of HLA-A, B, and C molecules involved as recognition structures at the target cell surface.

Antigen-Antibody Reactions↗
PubMed1979

Histocompatibility antigens in patients with leprosy from Azarbaijan, Iran.

The distribution of 24 histocompatibility antigens in 88 Azerbaijani patients with leprosy was determined and compared with those of 125 normal, ethnically matched individuals. HLA-BW35 was increased in frequency among the Kurdish patients as compared to the controls; HLA-A1, however, displayed decreased frequency in patients with the lepromatous form of the disease. Among the Turks, diminished frequency of HLA-BW15 was noted in the total patient population. None of these comparisons, however, reached statistical significance when corrected for the number of antigens tested. Across the two ethnic groups, differences in the frequencies of HLA antigens between the patients and the controls were only marginal.

HLA Antigens↗
PubMed2026

HLA-A ∗01:01 Allele Is Associated With Increased Risk of Transplant-Related Mortality After MHC Matched Unmodified Allogeneic Hematopoietic Stem Cell Transplantation.

Acute graft-versus-host disease (aGvHD) remains a substantial cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (allo-HCT). Limited studies explore the association between specific major histocompatibility complex (MHC) alleles and aGvHD or transplant-related mortality (TRM). After a noted clinical trend of higher TRM among a series of patients with aGvHD and MHC class I HLA-01:01, we retrospectively evaluated transplant outcomes of 404 adult allo-HCT patients who underwent unmodified allografts between 03/2010 and 02/2017. HLA-01:01 was expressed by 104 (25.7%) patients. In a univariate analysis, patients who underwent unmodified transplants and expressed HLA-01:01 had a higher risk of TRM (HR 1.63 [95% CI: 1.05-2.53], p = 0.035). In a multivariate cause-specific Cox model, HLA-01:01 was significantly associated with TRM after adjusting for grade II-IV aGvHD, conditioning regimen intensity, and age at transplant (HR 1.59 (95% CI: 1.02-2.48) p = 0.039). There were no significant differences in overall survival (OS), aGvHD, or chronic GvHD based on HLA-01:01 expression. With confirmation in a larger cohort, these findings have potential implications for the selection of allograft type, conditioning regimen, and post-transplant monitoring for this high-risk population.

Humans↗
PubMed1979

Further study on HLA-A, B, C, D, DR and haplotype antigen frequencies in psoriasis vulgaris.

HLA-A, B, C, D, and DR antigens in 40 Japanese patients with psoriasis vulgaris were analysed using the antisera obtained from the Seventh International Histocompatibility Workshop. The most deviant HLA antigens in psoriasis were found to be HLA-Cw6 and DRw7. by observing the HLA-A, B, C and DR antigens en bloc in psoriasis, it is shown that the statistically significantly associated haplotype antigens were HLA-A1, B13, Cw6 and DRw7, and A1, B37, Cw6 and DRw6 respectively. No HLA-Dw11 (LD17) antigen was associated with the disease.

Epitopes↗
PubMed1977

Population and family studies to demonstrate Ir genes: HLA haplotype in atopic allergy.

47 normal healthy controls and 45 atopic individuals together with five families with allergic diathesis and sensitive to mite antigen were typed for 13 HLA antigens. In general population, HLA-A1 and HLA-A8 were found to be higher than in normal controls. But the difference was significant at a level of p 0.05 after correction was made for the number of HLA antigens used. In one family, an HLA-A1 -B8 haplotype seems to be linked to the manifestation of atopic disease. The pattern of association of an HLA-A9 -B7 haplotype with the disease process in another family indicates that multiple genes may be involved in the manifestation of a variety of allergic disorders. Although more than one HLA haplotype of HLA-associated Ir gene for one antigen have been postulated, we still do not have enough evidence to suggest linkage between HLA haplotypes and atopic allergy. Further studies utilizing mixed lymphocyte culture and carefully matched control with a large number of subjects and more families are in progress to study the genetic basis of allergic diseases.

Asthma↗
PubMed1979

Assembly and maturation of HLA-A and HLA-B antigens in vivo.

HLA-A and HLA-B antigens are integral membrane glycoproteins which consist of a glycosylated heavy chain embedded in the membrane in noncovalent association with beta 2-microglobulin, a water-soluble polypeptide. The assembly and maturation of these antigens has been studied in vivo in the human B lymphoblastoid cell line T5-1 (HLA-A1, -A2, -B8, -B27). Two antigenically distinct populations of HLA-A and -B heavy chains can be detected by antisera which recognize determinants sensitive to the conformation of the heavy chain. One heavy chain population is associated with beta 2-microglobulin, whereas the other population is not. These populations can be further distinguished by their oligosaccharide structure and their localization within the cell. Pulse-chase experiments demonstrate a precursor-product relationship between these heavy chain populations and suggest the following pathway for the assembly and maturation of HLA-A and -B antigens. The completed heavy chains initially carry high mannose oligosaccharides and are largely or wholly associated with beta 2-microglobulin. During the next 10-15 min, association with beta 2-microglobulin occurs and the heavy chain conformation is altered. Beginning at about 30 min after synthesis, the oligosaccharides are converted from the high mannose form to the complex form, and between 60 and 80 min after synthesis, the mature antigens appear at the cell surface. These observations are discussed in relation to in vivo and in vitro studies on the biosynthesis of a variety of secreted proteins and membrane proteins.

Cell Line↗
PubMed1979

HLA system, psychiatry and psychopharmacology.

1. A number of antigens of the HLA system showed significant associations with clinical phenotypes of schizophrenia and manic depressive disorders. Even though we emphasize the need to consider these results with caution, we suggest that the findings now available indicate that the chromosomal regions which control the HLA system also contain the genetic material related to schizophrenia. On the other hand, although initial results have been encouraging, more work is needed before we can draw definite conclusions about the relationships between HLA antigens and the genetics of manic depressive disorders. All this recently acquired information is discussed and new lines for research are also suggested, including linkage studies in families, which might offer a more precise understanding of the genetic contribution to psychopathology. 2. Stressed also is the possibility that HLA determinants interfere with the interaction between neurotransmitters and/or psychotropic drugs and specific receptors. In this light, the clinical implications of HLA-A1 reactions to chlorpromazine and haloperidol, and of the HLA-A1 cross-reacting antigens are analyzed. Such studies are as yet very preliminary; however they perhaps help to clarify both the real biological roles of these antigenic membrane structures and the mechanisms by which psychotropic drugs interact with membrane receptors.

Bipolar Disorder↗
PubMed1977

HLA-A1, B8-phenotype association and HBs antigenemia evolution in 440 hemodialyzed patients.

HBs antigen (HBsAg) has been followed up every month in 440 hemodialyzed patients, typed for 26 HLA alleles of the A and B loci. An abnormally high rate of the HL-A-A1, B8 association (18.6%) was found in the group of patients able to eliminate HBsAg, when compared with the normal French population (5.05%, p less than 10(-4), and with the group of patients unable to eliminate HBsAg (7.0%, less than 0.01). Chronic aggressive hepatitis was only found in the latter. This high frequency of the HLA-A1, B8 association has also been found in patients with seronegative active chronic hepatitis and suggests that this phenotype might be associated with high immune response against HBsAg.

Chronic Disease↗
PubMed1979

HLA-A and B antigen frequencies in Welsh coalworkers with pneumoconiosis and Caplan's syndrome.

HLA typing was performed on 267 Welsh coalworkers with pneumoconiosis (96 cases of simple pneumoconiosis, 115 cases of progressive massive fibrosis and 56 cases of Caplan's Syndrome) and 134 coalworkers with no abnormality. The presence or absence of rheumatoid factor was also determined. The results fail to confirm a previously reported increase in HLA-A1 and B18 in coalworkers with no pneumoconiosis. When correction was made for the number of antigens typed (i) HLA-Bw21 was significantly increased from 1.1% in the total group with pneumoconiosis to 8.2% in coalworkers with no abnormality (P corrected less than 0.032); (ii) HLA-Bw45 was increased in Caplan's Syndrome (10.7%) and Caplan's Syndrome patients with rheumatoid factor (16.1%) when compared to a non-occupationally exposed control group (0.8%) (P corrected = 0.019 and 0.0064 respectively). These results were not significant when comparisons were made with the coalworker group with no abnormality. The apparent higher frequency of Bw45 in Welsh coalworkers is discussed.

Caplan Syndrome↗
PubMed1979

HLA antigens in a Scottish psoriatic population.

Sixty-one patients in the Dundee area suffering from psoriasis were typed for HLA-A and HLA-B antigens. On the basis of the typing results, the patients were divided into three groups, and studied with respect to sex, age of onset and familial incidence of the disease. The frequency of HLA-A1 appeared to be increased and HLA-B7 decreased but HLA-B13 and HLA-B17 were highly significantly increased (P less than 10(-6) and P less than 10(-10) respectively) in the psoriatic group compared to 204 controls. Of particular interest was a highly significant association of HLA-A1 with HLA-B17 in psoriatic patients. Family studies showed HLA-B17 to be a useful genetic marker for psoriasis in the families of B17 positive patients. Considerations of age of onset, familial incidence and typing data suggest that there is heterogeneity of genetic susceptibility to psoriasis and that one probable mechanism is the dominant inheritance of a "disease allele" in linkage disequilibrium with the allele coding for HLA-B17.

Chromosome Mapping↗
PubMed1977

HLA and MLC typing in patients with Hodgkin's disease.

HLA typing for 27 A and B locus antigens was performed in 137 Caucasian patients with Hodgkin's disease. A and B locus antigen frequencies were compared for the entire group of patients, for 51 patients studied in a prospective manner and for 62 patients surviving with Hodgkin's disease for more than 5 years. MLC typing (HLA-D) was performed in 51 unselected Caucasian patients using 6 differend HLA-D homozygous test cells which define 3 HLA-D specificity groups (DW2, DW3, and DW4). HLA-AW33 was found in 0.0% of patients and in 5.9% of random Caucasian blood donors at the Sloan--Kettering Institute (X2 equals 7.04, p less than 0.01). HLA-A1 was found to be increased to 35.8% in the entire patient group (N = 137) as compared to 25.4% in 855 random North American Caucasians (X2 = 5.97, p less than 0.02). There was no significant deviation of any A or B locus antigen in relation to sex, histology, age of patient, or duration of survival (newly diagnosed vs 5-year survivors). No significant deviation for either of the 3 common HLA-D determinants (DW2, DW3, or DW4) was observed.

Adult↗
PubMed1976

HLA antigens and atopic features in steroid-responsive nephrotic syndrome of childhood.

Atopic systems were more common in children with steroid-responsive nephrotic syndrome (S.R.N.S.) than in matched controls, and HLA-B12 was more common in children with S.R.N.S. than in adult controls. Atopic symptoms (particularly hayfever), positive prick tests with grass pollen antigens, and a higher mean serum concentration of IgE antibody to timothy grass pollen were more common in nephrotic children with HLA-B12 than in those without HLA-B12. There was also an increased frequency of the haplotype HLA-A1 and HLA-B8, mainly among the non-atopic patients.

Adolescent↗
PubMed1979

HLA-B17 and the HLA-A1, B17 haplotype in acute myelogenous leukemia.

Seventy-nine Caucasians with acute myelogenous leukemia (AML) were genotyped to determine whether AML, the induction of remission or patient survival were associated with particular HLA phenotypes or haplotypes. HLA-B17 and B27 were increased in AML patients over 40 years of age. Combined analysis of four independent studies indicates that HLA-B17 is significantly but weakly associated with AML, relative risk = 1.48 (.01 less than P less than .025). The A1, B17 and Aw24, Bw35 haplotypes occurred more frequently in the AML group as compared to racial and geographic controls (uncorrected P = 0.0068 and 0.0098, respectively Fisher's Exact Test). Induction of remission occurred less frequently in patients with the B17 phenotype as compared to patients lacking this antigen (P = 0.047). Patient survival was associated with remission status (P = 0.002) but was not significantly associated with particular HLA phenotypes or haplotypes. These results indicate that a gene or genes in the HLA-B region of the major histocompatibility complex can influence susceptibility to AML and also the response to chemotherapy.

Adolescent↗
PubMed1978

Increased frequency of HLA-DRW4 in chronic active hepatitis.

HLA-A, B, C and DRw typing was performed on peripheral blood lymphocytes of 17 adults with the diagnosis of chronic active hepatitis made by liver biopsy as the only criterion for study. An increase in the frequency of HLA-DRw4 (71 vs. 24%, p less than 0.005) was observed, but there was no increased frequency of HLA-A1, B8 or any other HLA locus specificity.

Adult↗
PubMed1979

Anti-tissue antibodies and immunoglobulin levels in relation to HLA and other markers in Icelandic families.

Studies of 521 sera from the Icelandic cousin marriage project were made to assess the incidence of various anti-tissue antibodies and the levels of immunoglobulins, as these were considered to be useful markers of the humoral immune response. Comparisons were made between these parameters and the HLA-A and B antigens, the blood groups, the immunoglobulin allotypes (Gm, Km and Am), the properdin factor (Bf), and other markers. These investigations offered another approach to the study of the sites of action of immune response genes in man. Because the immune response may be expected to differ for each individual and depend at least in part, on the degree of exposure to different antigens, no absolute correlation was expected. There was, however, a marked association between certain IgG anti-tissue antibodies and HLA antigens. This was most marked for HLA-A10, B18 and b27, but not for HLA-A1 or B8. The comparison of immunoglobulin levels with HLA antigens, was less striking, although HLA-A2 appeared to be associated with low levels of IgE. There were also some associations between immunoglobulin levels and ABO blood groups.

Aged↗
PubMed1979

The polyglandular failure syndrome: disease inheritance, HLA type, and immune function.

The occurrence of disease and the inheritance of histocompatibility leukocyte antigens (HLA) were evaluated in 11 patients with the polyglandular failure syndrome and 42 of their relatives. The gene frequency of the HLA-B8 allele (seven of 22) and the HLA-A1, B8 haplotype phenotype frequency (five of 11) were increased in patients with polyglandular failure as compared with a control population. Eleven of 42 relatives had a polyglandular failure illness. Disease prevalence correlated with HLA inheritance in some families, but not all. Patients and diseased relatives had a high incidenceof immunologic dysfunction: autoantibodies, including antinuclear antibodies; elevated serum immunoglobulins (three of 16); abnormal skin tests (four of nine). Polyglandular failure appears to be an HLA-B8-associated syndrome with a high prevalence of disease in relatives. Immunologic dysfunction resulting from a gene(s) on chromosome 6, in linkage dysequilibrium with the HLA-B8 allele, may be a factor in the pathogenesis of polyglandular failure illnesses.

Addison Disease↗
PubMed1978

HLA-B8 in caucasian patients with systemic lupus erythematosus.

HLA antigen frequencies were determined in 27 Caucasians with systemic lupus erythematosus (SLE). A statistically significant association between HLA-B8 and SLE was found. HLA-B8 occurred in 48% of patients and in 18% of controls (P corr approximately equal to 0.005). The relative risk of SLE for HLA-B8 carriers is 4.23. In addition, SLE patients with later onset of disease more frequently had HLA-A1 and/or HLA-B8. There was no association between any HLA antigen and clinical (renal, central nervous system, and lung involvement) or serological (antinuclear and anti-nDNA antibodies) parameters.

Adolescent↗