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Results for “HLA matching”

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At least 19 recordsLinked to original sources
PubMed1979

Significance of HLA matching in renal transplantation. A prospective one-center study of 485 transplants matched or mismatched for HLA-A, B, C, D, and DR antigens.

Matching for HLA haplotypes as well as for HLA-A and B antigens improved graft survival in 112 living related first transplants. In cadaveric first transplants, matching for HLA-A and B antigens had a beneficial effect on the fate of 373 grafts, while matching for HLA-C antigens had no predictive value. One hundred seventeen cadaveric transplants and their recipients were prospectively typed for the HLA-DR antigens. Compatibility for HLA-DR was found to be prognostically beneficial irrespective of matching for HLA-A and B antigens, and with no difference between transfused and nontransfused patients. Matching both for HLA-A , B and D/DR was thus found to influence the outcome of renal transplantation.

Adult↗
PubMed1977

The importance of HLA matching in primary cadaveric kidney transplantation in Gothenburg.

The importance of HLA matching was studied for 319 primary cadaveric kidney transplantations during the period 1969-1976. During 1969-1972 the HLA match was the basis for recipient selection and most cases belonged to match grade 0 or 1. Graft survival was significantly better for match grade 0. Within match grade 1 cases with one foreign HLA B antigen had lower graft survival than cases with one foreign HLA A antigen, indicating the importance of the HLA B series. During 1973-1976 the HLA match was hardly considered in recipient selection. HLA matching during this period seemed to be of less importance, except for match grade 0 and the totally mismatched cases. When matching was performed for the HLA B series, it was found that graft survival was significantly improved when no or only one foreign HLA B antigen was present. The prognosis for cases with foreign HLA B antigen was significantly better during the later period.

Cadaver↗
PubMed1977

Effect of blood-group on relation between HLA match and outcome of cadaver kidney transplants.

In a series of 4998 cadaver kidney transplants the extent of HLA matching correlated with transplant outcome in patients with blood-groups other than O (non-O) but not in patients of blood-group O. The high survival-rate of poorly matched kidneys in O recipients was responsible for the lack of correlation between HLA matching and graft survival in these patients. Survival-rates of transplants with 4 HLA mismatches were 52 +/- 3% at one year in 222 O-to-O grafts compared with 24 +/- 5% in 65 B-to-B grafts (P less than 0.0001). In 2827 non-O patients, there was a strong correlation between HLA matching and graft survival (P less than 0.0001 at one year). One possible reason for the cancelling out of the effect of HLA mismatching in type-O recipients is that these patients waited longer on dialysis for a transplant and consequently received more blood-transfusions.

ABO Blood-Group System↗
PubMed1977

First experiences with HLA-matched corneal grafts in high risk cases.

In highly vascularized corneas the number of graft failures caused by irreversible rejections is higher than in non-or slightly vascularized corneas. The importance of antigen compatibility is demonstrated, especially in these 'high risk' cases. Ten highly vascularized corneas were grafted with HLA-matched donor material; only one reversible rejection was seen in this group. Nine non-or slightly vascularized corneas were grafted with donor material chosen a random. Retrospective HLA matching was performed. Three irreversible rejections were seen in this group. The number of HLA incompatibilities was high.

Corneal Transplantation↗
PubMed2024

A healthy live birth after mosaic blastocyst transfer in preimplantation genetic testing for GATA1-related cytopenia combined with HLA matching.

BACKGROUND: GATA1-related cytopenia (GRC) is characterized by thrombocytopaenia and/or anaemia ranging from mild to severe. Haematopoietic stem cell transplantation (HSCT) is a healing therapeutic choice for GRC patients. We identified a novel pathogenic variant (GATA1: c.1019delG) in a boy with GATA1-related cytopenia. Then we performed preimplantation genetic testing (PGT) in this GRC family. After a mosaic embryo transfered, a healthy and HLA-compatible with the proband baby was delivered. CASE PRESENTATION: The proband is a 6-year-old boy who was diagnosed to have transfusion-dependent anaemia since 3 year old. Whole-exome sequencing (WES) showed that the proband has a hemizygous variant c.1019delG in GATA1, which is inherited from his mother. His parents decided to undergo PGT to have a health and HLA-compatible offspring. After whole genome amplification (WGA) of biopsied trophectoderm (TE) cells, next generation sequencing (NGS)-based PGT was preformed to analyse embryos on chromosomal aneuploidy, target mutation and HLA typing. There were 3 embryos HLA-matched to the proband. The genotypes of the 3 embryos were heterozygous variant, hemizygous variant, normal respectively. After a heterozygous, mosaic partial trisomy (chr)16, and HLA-matched embryo transfer, a healthy baby was delivered and whose HSCT is compatible with the proband. CONCLUSIONS: NGS-based PGT-HLA is a valuable procedure for the treatment of GATA1-related cytopenia caused by GATA1 variants, or other haematological disorders, oncological and immunological diseases. Furthermore, our study reconfirms that mosaic embryos transfer would bring healthy offspring.

Child↗
PubMed1979

Advances and disappointments, indications and restrictions regarding HLA-matched corneal grafts in high risk cases.

54 corneas, 49 high risk cases and 5 low risk cases, were grafted with HLA-matched donor material. The importance of antigen compatibility especially in high risk cases is demonstrated. The percentage of irreversible rejections and reversible rejections in this group is markedly smaller as compared with our own "at random" material and the "at random" material of other authors. The follow-up period is 3--21 months.

ABO Blood-Group System↗
PubMed1978

Influence of HLA matching and blood transfusion on renal allograft survival.

One hundred and seven consecutive cadaver kidney transplants have been followed for up to 6 years. The beneficial effect of HLA matching, shown in previous studies, has been confirmed. The 2-year failure rate from rejection was 29% for grafts with less than two incompatibilities, in comparison with a figure of 52% where there were two or more incompatibilities. In contrast to some reports, the presence of HLA antibodies did not have an adverse effect on the survival of first grafts. Patients not transfused prior to transplantation had a much higher 1-year graft failure rate (72%) than those given either frozen-thawed red cells (29%) or whole blood (23%). This apparently beneficial effect of blood transfusion was no greater in patients transfused with more than five units compared with those given less than five units. We believe that blood transfusion has an important influence on the outcome of renal transplantation.

Adolescent↗
PubMed1977

HLA matching and cadaver kidney transplant survival in North America: influence of center variation and presensitization.

In an analysis of 4,851 first cadaver kidney transplants, we found a statistically highly significant correlation between the number of HLA antigens mismatched and graft survival (P less than 0.0005 at 1 year). The difference in the survival rates of grafts with no HLA mismatch compared with grafts with four mismatches was 11 to 12%, similar to results of previous analyses. HLA-A locus antigens had a slightly stronger effect than B locus antigens. The correlation of HLA matching with graft survival was most significant at centers with poor overall transplant outcome, and there was no correlation at centers with very good overall results. Presensitization also had the strongest effect at centers with poor overall graft survival.

Cadaver↗
PubMed1976

HLA matching and corneal grafting.

A series of 200 cases of full-thickness corneal allografts have been followed to determine whether HLA and ABO incompatibility influence prognosis of the grafts. 85% of patients with avascular corneas had clear, functioning grafts one year after transplantation. Only 33% of patients with severely vascularised corneas had successful grafts one year after transplantation. A significant association was found between severe vascularisation of the patient's cornea and irreversible graft rejection. In this group of patients, the proportion of grafts functioning was found to be ranked according to the number of HLA antigens shared by graft donor and recipient. Patients receiving grafts matching for 2 HLA antigens showed a failure-rate due to irreversible rejection of 26% at one year, in comparison with 57% and 62% of grafts matching for 1 or 0 HLA antigens respectively. ABO incompatibility or ABO phenotype of the recipient did not influence graft prognosis. The results indicate that patients with severely vascularised corneas should receive HLA-matched corneal grafts. The institution of HLA-typed cornea "banks" for treatment of such patients is advocated.

ABO Blood-Group System↗
PubMedDate not supplied

Influence of HLA matching on kidney graft survival.

The influence of matching for the whole HLA haplotype as well as for the separate HLA antigens controlled by this region, was studied in a material of 98 living related and 178 cadaveric first transplants. Graft survival corresponded closely to the degree of HLA haplotype disparity between donor and recipient. Furthermore, graft survival was less in combinations being incompatible for the serologically defined HL-A and -B antigens as compared to compatible combinations. A weak MLC response between donor and recipient, even in the presence of HL-A and -B disparity, might signify prolonged graft survival.

Consanguinity↗
PubMed1976

Influence of HLA matching and blood-transfusion on outcome of 502 London Transplant Group renal-graft recipients.

The outcome of 502 cadaver kidney transplants has been followed for up to six years; these grafts were arranged through the Tissue Immunology Unit of the London Hospital Medical College, the coordinating centre of the London Transplant Group. An analysis of HLA (A and B) recepient-donor matching revealed, as in previous analyses, clear differences (now highly significant) between the best as compared with the lesser matched recipients. A quarter of the patients (group 4 and 3a) had a superior outcome 20-30% greater than poorly matched (2 or less group) which constituted 53% of individuals. The results in the 3b group (28% of patients) were intermediate 10-15% better than the "2 or less antigens in common" group. A small number of recipients mostly 4 or 3 matched who were retrospectively HLA-D matched showed an even better graft survival. The effect of blood-transfusion before transplantation was studied and found to improve the outlook especially in the best-matched groups. No difference was apparent between those receiving less or more than ten units except in a group of patients with cytotoxic antibodies and/or retransplants. This "immunocompetent-presensitised" group had the best outcome provided these recipients had few transfusions and were subsequently well matched. These findings emphasise the continued need for successful collaborative associations, so that improved matching can be achieved which if universally applied would ensure better graft survival for a large number of patients in renal failure.

Binding Sites, Antibody↗