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Results for “HEPATIC COMA”

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At least 19 recordsLinked to original sources
PubMed1982

Histopatological findings of the liver before and during hepatic coma in fulminant hepatitis.

The histopathological findings of the liver taken by needle biopsy before and during hepatic coma of fulminant hepatitis were studied in 3 patients; two died and one survived. In the first fatal case, massive hepatic necrosis was already present 7 days before the development of hepatic coma. In the second fatal case, submassive hepatic necrosis was seen during coma grade IV. In both cases, histological findings of the biopsy liver specimens were in accord with those of the autopsied liver. In the third survived case, diffuse degeneration and multilobular liver cell necrosis were found on the biopsy specimen taken immediately after the development of hepatic coma, grade IV.

Adolescent↗
PubMedDate not supplied

[Plasmapheresis in the treatment of hepatic coma complicating viral hepatitis].

Therapeutic plasmaphereses using CS 3000 Fenwal Cell Separator were performed in 4 women and 2 men, aged between 17 and 44 years, with hepatic coma complicating acute viral hepatitis type B. One to four plasma exchanges per patient were performed, usually at the volume of 3000 ml per procedure. Two patients at II and IVa period of the coma, according to Aboun classification, survived. Four patients at II, III and two at III/IV period of the coma died. The authors suggest that in some cases exchange of large volumes of plasma in the treatment of hepatic coma complicating acute viral hepatitis may be a lifesaving procedure.

Acute Disease↗
PubMed1969

Management of hepatic coma complicating viral hepatitis.

The treatment is described of 17 patients with presumed viral hepatitis who developed hepatic coma unresponsive to standard conservative measures. Five patients were considered for treatment by exchange transfusion. Four were treated, with transient improvement in two, but all died. Nine patients were considered for treatment by heterologous liver perfusion. Six were treated, with transient improvement in two and complete recovery in one. The last patient remains well 12 months later. Dialysis in four patients had no effect on the coma; the addition of albumin to the dialysate did not increase the extraction of bilirubin. The clinical course in most cases was irregular. Complications were common, the most important being cerebral oedema with medullary coning, bleeding, bacterial infection, hypoglycaemia, and pancreatitis. Heterologous liver perfusion was the most efficient method of removing bilirubin. However, it is not yet clear whether it is more effective than exchange transfusion in the treatment of the patient.

Adolescent↗
PubMed1960

HEPATIC coma.

Explore the source record for details and available documents.

Hepatic Encephalopathy↗
PubMed1976

[Therapeutic effect in 3 cases of hepatic coma in viral hepatitis].

The author reports his observation on three cases of coma hepaticum in viral hepatitis treated at the Internal Diseases Ward, Military Hospital, in the town of Asmara, Ethiopia. Parallelly with the usual hepatoprotective drugs and antibiotics, corticosteroids were administered as well as the preparation Reducdyn, containing homocysteine and cysteine-carriers of sulphhydryl groups. Complete restoration to health was achieved in two of the patients after three days in grave coma. The third patient was aroused from the comatose state for six hours but later had a lethal end on the eighth day post coma onset. According to the author, the combination of that preparation with corticosteroids is pathogenetically grounded and enables the administration of the latter in lower and safe doses. The author stresses upon the importance of early therapy in coma hepaticum.

Adult↗