Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “HEMATURIA”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMed2001

[When is it meaningful to investigate hematuria? Macroscopic hematuria--investigate always. Microscopic hematuria--symptoms and age decide].

All patients (n = 578) referred during one year and for whom hematuria was mentioned in the referral form were monitored following urological evaluation including urography and cystoscopy. Evaluation of macroscopic hematuria was often associated with significant findings at both urography (stones) and cystoscopy (bladder tumors). The situation was the same even if not as pronounced for evaluation of microscopic hematuria with concomitant urinary tract symptoms. The evaluation of asymptomatic microscopic hematuria was, however, very rarely associated with significant findings, which were moreover totally lacking among women and younger males.

Adult↗
PubMed2002

The BTA stat test is nonspecific for hematuria: an experimental hematuria model.

PURPOSE: An experimental hematuria model was designed to determine whether the bladder tumor antigen (BTA) stat test (Bion Diagnostics, Redmond, Washington) is influenced by microscopic or macroscopic hematuria. MATERIALS AND METHODS: A total of 25 healthy subjects provided urine and blood samples for the study. All subjects had a negative BTA stat test initially. Normal urine was mixed with autologous blood to cause hematuria of 3 degrees of severity. The test was performed in each sample after the creation of hematuria. RESULTS: BTA stat assay specificity in the presence of microscopic and gross hematuria was 80% and 24%, respectively. Results varied depending on the severity of hematuria, that is 20% for microscopic and 76% for gross hematuria. CONCLUSIONS: The results of the BTA stat test in the presence of microscopic hematuria must be interpreted in regard to the degree of hematuria. The test is not reliable in urine samples with gross hematuria due to a high false-positive rate.

Adult↗
PubMed1989

The significance of adult hematuria: 1,000 hematuria evaluations including a risk-benefit and cost-effectiveness analysis.

Between March 1976 and June 1985, 1,000 consecutive adults with asymptomatic gross or microscopic hematuria in the absence of proteinuria were evaluated urologically. Lesions that could account for the hematuria were detected in 88.3 per cent of the patients. Life-threatening lesions were diagnosed in 9.1 per cent of the patients, while lesions requiring at least observation were present in 22.8 per cent. The incidence of life-threatening lesions increased with age, with a sharp increase after age 50 years. Life-threatening lesions were more common in men (13.6 per cent) than in women (4.9 per cent). In general, as the degree of hematuria increased so did the yield of life-threatening lesions; however, there was no "safe" lower limit of hematuria. Of the patients with life-threatening lesions 18.6 per cent had at least 1 urinalysis with less than 3 red blood cells per high power field within 6 months of the diagnosis. The direct medical cost of a hematuria evaluation was $777. The difference in direct medical costs to diagnose and treat localized versus metastatic genitourinary cancer was $48,070 in 3 matched pairs of patients. In this study group 77 of 84 patients (92 per cent) diagnosed with genitourinary cancer had localized disease. A hematuria evaluation was cost-effective for all groups studied. A literature-based estimate of the life-threatening risks of diagnostic studies applied to the study data resulted in a 1.1 per cent life-threatening risk per hematuria evaluation. For all categories studied, except for women less than 40 years old with microscopic hematuria, the risk of a hematuria evaluation was less than the incidence of life-threatening lesions discovered as a result of the evaluation. Asymptomatic hematuria, whether gross or microscopic, is a significant finding and warrants evaluation from a risk-benefit and cost-effectiveness standpoint.

Adult↗
PubMed1986

Primary renal hematuria presenting as unilateral gross hematuria.

A patient with unilateral gross hematuria was found to have mesangial proliferation and IgM deposition on renal biopsy, consistent with the entity of primary renal hematuria. This case refutes previous assumptions that renal biopsy is normal in patients with unilateral hematuria. Glomerular lesions may be more common than previously suspected in the setting of unilateral hematuria. Renal biopsy can be useful both to define the natural history of unilateral hematuria and prevent repeated diagnostic procedures in patients with abnormal biopsies.

Adult↗
PubMed1990

Hypercalciuria and postglomerular hematuria in children. The effects of thiazide on calcium excretion, urine saturation with respect to calcium-hydrogenphosphate and hematuria.

Calcium-hydrogenphosphate was considered as one of the main factors governing renal calculus formation. The degree of saturation (expressed as activity product = AP) with respect to this phase was therefore calculated in urines of 36 hypercalciuric children (20 absorptive, 16 renal subtype) with isolated hematuria and 30 healthy controls. The effect of thiazide treatment on the urine saturation and on the evolution of hematuria was also investigated. The results were compared to the urinary calcium excretion (expressed as Ca/cr ratio). Urines of both hypercalciuric groups were saturated on basal conditions (AP above 3.5 x 10-6 mol2/l2; -lgAP below 6.4), the values differed significantly from those of the controls (-lgAP = 6.78 +/- 0.4 in the control-; 6.1 +/- 0.25 in absorptive-, 6.03 +/- 0.34 in renal hypercalciuria; p less than 0.001). Thiazide normalized the activity product in all groups. During thiazide therapy significant decrease in the occurrence of hematuria was noted (p less than 0.001 in both hypercalciuric groups). These data furnish further evidence on the relation of hypercalciuria and postglomerular hematuria. Simultaneous determinations of the state of saturation may provide further information on the "stone forming potential" of the urines investigated.

Adolescent↗
PubMedDate not supplied

Effect of thiazide on urinary calcium excretion and hematuria in children with postglomerular hematuria.

The effect of short term hydrochlorothiazide therapy on urinary calcium excretion was compared to that of low calcium and a combined low calcium and low sodium diet in 30 children with postglomerular hematuria. On basal conditions 9 children were normocalciuric, 11 had absorptive, 10 renal hypercalciuria. The effect of thiazide treatment on the haematuria was also evaluated. Thiazide revealed to be more effective in reducing calcium excretion than low calcium diet alone in all groups (p less than 0.001 in normocalciuria; p less than 0.01 in both hypercalciuric groups). Combined low calcium--low sodium diet and thiazide treatment were equally effective in reducing calcium excretion in the hypercalciuric groups. On the first 3 days of thiazide treatment a slight increase of hematuria was observed; in the following period a significant decrease in the occurrence (p less than 0.01 in both hypercalciuric groups) and degree (p less than 0.01 in absorptive; p less than 0.02 in renal hypercalciuria) of hematuria was noted. These data furnish further evidence on the relation of hypercalciuria and post-glomerular hematuria.

Adolescent↗
PubMed1996

Isolated hematuria in adults: IgA nephropathy is a predominant cause of hematuria compared with thin glomerular basement membrane nephropathy.

We examined kidney biopsy specimens obtained from 40 adult patients with isolated hematuria to determine the renal pathology and the incidence of thin glomerular basement membrane nephropathy (TGBMN). Light microscopy showed minor glomerular abnormalities in 26 patients (65%), focal and segmental lesions in 3 patients (8%), and mild diffuse proliferative glomerulonephritis in 11 patients (28%). Immunofluorescence microscopy showed IgA nephropathy (IgA-N) in 16 patients (40%), in whom no progressive lesions were identified. We measured the glomerular basement membrane (GBM) thickness using electron microscopy, and TGBMN was identified in 4 patients (10%). Our results suggest that IgA is a major pathological finding in adult patients with isolated hematuria. GBM thinning does not appear to be a major cause of glomerular hematuria.

Adolescent↗
PubMed1989

[Microscopic hematuria. Semiologic value in urology. Management of microscopic hematuria].

Microscopic hematuria, a frequent cause for consultation, poses a problem regarding its significance. It is essential that a curable pathology is not neglected. In the absence of associated clinical data, nephrological orientation of investigations depends on the study of urinary sediments and phase contrast microscopy. Where there is a urological orientation, half the lesions involve the lower urinary tract; the use of flexible urethrocystoscopy has been a true advance in terms of its simplicity and reliability. When a lesion is demonstrated the question still remains as to whether it is in fact responsible for the microscopic hematuria. It is best to remain prudent when a poorly significant lesion is discovered. Since 20% of microscopic hematurias remain unexplained, how far should one go in the paraclinical investigation and follow up of involved patients?

Adult↗
PubMed2003

Alport syndrome and benign familial hematuria (thin basement membrane disease) in two brothers of a family with hematuria.

Alport syndrome (AS) and benign familial hematuria (BFH) are inherited disorders of the glomerular basement membrane, which are sometimes difficult to differentiate at the early stage without type IV collagen staining of the renal basement membrane. Previous studies have indicated that mutation of type IV collagen alpha4 gene may be responsible for both BFH and AS. We report here a Japanese family with consanguinity, in which autosomal-recessive AS and BFH were separately identified in two brothers on the basis of findings of electron microscopy and type IV collagen chain staining of the renal biopsy specimens. Their parents, being first cousins, paternal uncle and grandmothers were found to have hematuria. Our observations suggest that BFH patients were heterozygous carriers of autosomal-recessive AS.

Basement Membrane↗
PubMed1998

[Values of phase-contrast microscopy in the etiological diagnosis of hematuria in adults. Part I. Establishing individual norms for glomerular hematuria].

UNLABELLED: In the cohort of 123 patients (average age 44 years) criteria for glomerular and nonglomerular hematuria (H) were established by phase-contrast microscopy (PCM). According to literature, hematuria was divided into glomerular, mixed or nonglomerular if: > 60%, 20-60% and < 20% dysmorphic erythrocytes (E) of fresh morning urine sediment were found. Diagnosis of glomerulonephritis was confirmed by renal biopsy in 54/57 glomerular H as well as in all 8 cases of mixed H. On the contrary, urological reasons for H were found in 55/58 cases of nonglomerular H with normal renal biopsy in the remaining 3 patients. Using value > 20% of dysmorphic E as a new norm for glomerular H, we found sensitivity and specificity of this test as 100% and 95% respectively. IN CONCLUSION: glomerular H should be suspected and renal biopsy recommended when > 20% dysmorphic E are found by PCM what means exclusion of the term "mixed H".

Adolescent↗