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At least 19 recordsLinked to original sources

Renin stimulation by passive tilting: the influence of an anti-gravity suit on postural changes in plasma renin activity, plasma noradrenaline concentration and kidney function in normal man.

Plasma renin activity (PRA), plasma noradrenaline concentration, heart rate, blood pressure, and clearances of para-aminohippurate and inulin were measured in twelve normal subjects (clearances in only three subjects) before and after 40 min of 60 degrees upright tilting. The tilting experiments were repeated after inflation of an anti-gravity suit to 60 mmHg on the lower extremities. Inflation of the anti-gravity suit caused an abolition of the postural PRA increase, a marked reduction of the postural increases in plasma noradrenaline and heart rate, and elimination of the decreases in pulse pressure, inulin and para-aminohippurate clearances and sodium excretion. The results suggest a decisive role of the sympathetic nervous system for postural renin increase, probably mainly activated by stretch receptors in the low-pressure cardiopulmoanry area.

Adult

The gravity suit: a useful device in complicated urologic hemorrhage.

External counterpressure with a gravity suit was used to control intractable postoperative bleeding in 4 urologic patients. Two patients had coagulation defects, and 2 had been unsuccessfully reexplored prior to application of the G-suit. The bleeding was controlled with preservation and restoration of vital signs in each case. In 3 cases external counterpressure may have been lifesaving.

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The gravity suit: a major advance in management of gynecologic blood loss.

We have used the gravity suit (G-suit) to stabilize patients in shock as a result of ruptured ectopic pregnancies. Four patients presenting in shock were carefully studied with serial vital signs, fluid replacement, and blood loss before and after application of the G-suit. These studies were continued through surgery and the removal of the G-suit. The G-suit improved vital signs, increased peripheral organ and limb perfusion, and decreased blood loss in all cases.

Adult

An experimental microcomputer controlled system for synchronized pulsating anti-gravity suit.

An experimental system to deliver synchronized external pressure pulsations to the lower body is described in this technical note. The system is designed using a microcomputer with a real time interface and an electro-pneumatic subsystem capable of delivering pressure pulses to a modified anti-G suit at a fast rate. It is versatile, containing many options for synchronizing, phasing and sequencing of the pressure pulsations and controlling the pressure level in the suit bladders. Details of its software and hardware are described along with the results of initial testing in a Dynamic Flight Simulator on human volunteers.

Computers

Spontaneous rupture of the liver in pregnancy: a report of eight cases.

Seven cases of ruptured subcapsular hematoma and one case of ruptured hepatoma are reported. Six of the patients died, four following an unsuccessful operation. One patient survived following an operation, and another patient survived without surgical intervention. Both survivors were treated with a gravity suit to control internal hemorrhage.

Adult

Disabling postural hypotension complicating diabetic autonomic neuropathy.

A 35-year-old Type 1 diabetic man with severe disabling postural hypotension was studied for physiological abnormalities, precipitating factors, and effect of current treatment. A 24-h blood pressure profile indicated a diurnal variation in systolic blood pressure with the lowest values recorded between 0100 and 0600 h, during which the patient often lost consciousness on standing (mean standing systolic pressure 78 mmHg at night vs 105 mmHg in the afternoon, p less than 0.001). Food induced a profound fall in systolic pressure, both while supine and while standing erect. The systolic pressure fall during euglycaemia was 49 mmHg vs 3 mmHg during hypoglycaemia. Plasma noradrenaline and adrenaline levels were low during euglycaemia, but increased during hypoglycaemia. Therapeutic manoeuvres aimed at increasing heart rate (by atrial tachypacing) and reducing the peripheral pooling of blood (vasoconstricting drugs and gravity suit), together with the somatostatin analogue octreotide, proved ineffective. These observations demonstrate the phenomenon of post-prandial exacerbation of postural hypotension in a Type 1 diabetic patient, and indicate that despite failure of conventional methods of treatment, hypoglycaemia increased plasma catecholamines and was effective in abolishing the blood pressure fall on standing.

Adult

MAST suits.

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Animals

Modification of the normal postural changes in plasma renin activity by the application of positive pressure to the legs.

In six normal male subjects plasma renin activity (PRA) rose progressively on standing over a 2 hour period. PRA fell to basal levels after a further 2 hours of recumbency. The rate of rise of PRA on standing was largely abolised following the application of an anti-gravity ('G') suit. Continuous monitoring of blood pressure (BP) heart rate (HR) and packed cell volume (PCV) suggest that it is the fall in effective blood volume which elicits the stimuli to renin release during changes in posture.

Adult

The development of the Australian anti-G suit.

Prof. Frank Cotton of Sydney University, Australia, designed the world's first successful gas-operated anti-G suit. Research commenced late in 1940, and a suit was designed with rubber sacs covered externally by inextensible material. The sacs automatically inflated when G forces increased during flying. Initially tested on a centrifuge specially built at Sydney University, and then flight-tested in a Hurricane, Kittyhawks, and Spitfires, the suit provided about 2 G protection. The Canadians had earlier developed a water-filled suit, which the RAF adopted, but comparative trials in 1944 by the Royal Air Force concluded that: "There is no doubt the Cotton Suit gives the best protection." By the time the Cotton Aerodynamic Anti-G Suit was operational, Japanese attacks on Darwin had virtually ceased, and the suit was never used in combat. However, the principle of gas-inflatable bladders is still used in the modern anti-G suit.

Australia

The MAST suit in the treatment of cardiogenic shock.

Based on initial success using the medical antishock trouser (MAST) suit in treating 150 patients in traumatic, hypovolemic shock in the city of Bellingham and Whatcom County, Washington, at St. Luke's Hospital, the indications for its use have been expanded to include certain types of cardiogenic shock. The rationale was based on the frequent inability to differentiate hypo-, hyper-, and normovolemia in patients in cardiogenic shock and the need for a safe, reversible fluid challenge to differentiate these conditions. Changes in the condition of 14 patients in cardiogenic shock after application of the MAST suit were evaluated. Six patients responded with improved cardiac output and blood pressure. Four had no significant change in their condition and four became worse. In all patients whose condition was unchanged or worsened, the fluid challenge was reversed by deflating the suit. Based on these preliminary findings, it would seem that extended indications exist for using the MAST suit.

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