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At least 19 recordsLinked to original sources
PubMed1975

Multilating granuloma inguinale.

Granuloma inguinale is an uncommon infectious granulomatous disease of the inguinale area that can insidiously engulf and mutilate tissue. The reported case of granuloma inguinale demonstrated the painless progression of the disease to destroy most penile, scrotal, and inguinal tissue and also showed the subsequent satisfactory therapeutic result with antibiotic treatment. Light microscopy of plastic-embedded thin-sectioned tissue specimens allowed clear demonstration of the Donovan bodies and may be valuable in diagnosis.

Granuloma Inguinale↗
PubMed1998

Surgical treatment of granuloma inguinale.

Granuloma inguinale is an indolent, progressive, ulcerative and granulomatous skin disease caused by Calymmatobacterium granulomatosis. It is generally treated with antibiotics. However, long-standing and complicated disease requires surgical treatment. Two patients with extensive and multiple perianal fistulas and abscesses unresponsive to medical treatment were managed with radical surgical resection. The first patient healed by primary intention, but a diverting colostomy was made for the second patient and the tissue defect was closed with a rotation flap. Follow-up at 4 years revealed the disappearance of the symptoms and the absence of recurrence in both patients.

Adult↗
PubMed1997

Growth and cultural characteristics of Calymmatobacterium granulomatis--the aetiological agent of granuloma inguinale (Donovanosis).

Granuloma inguinale is a chronic destructive granulomatous disease of the genitalia. The clinical diagnosis is often unreliable and the definitive diagnosis is based on the visualisation of 'Donovan bodies' in tissue smears or biopsy specimens. The organism implicated in its aetiology, Calymmatobacterium granulomatis, was reported to have been cultured > 30 years ago, but little is known about the organism because of its fastidious nature and the difficulty in culturing it. Twenty-two biopsy specimens from female patients with clinical and laboratory-confirmed granuloma inguinale were treated with amikacin 10 mg/L and inoculated in a monocyte co-culture system with peripheral blood mononuclear cells (PBMC) from a single donor and autologous sera. The method was subsequently modified by pretreatment of specimens with vancomycin 5 mg/L and metronidazole 10 mg/L in addition to amikacin 10 mg/L for the purpose of decontamination, pooled blood donor PBMC and by the use of heat-inactivated fetal calf serum instead of autologous serum for culture. This modified method was used to culture additional biopsy specimens and genital ulcer scrapings from female and male patients, respectively. All monocyte co-cultures were examined by a rapid Giemsa (RapiDiff) stain and by an indirect immunofluorescence test with immune sera. Representative cultures were examined by transmission electron microscopy. C. granulomatis was successfully isolated in pure culture by the monocyte co-culture system from four biopsy specimens and 14 genital ulcer scrapings. The cultured organisms were visible both intra- and extra-cellularly and were extremely pleomorphic, with characteristic single and biopolar condensation. The numbers of the organisms increased after each passage. All positive cultures showed bright fluorescence when tested with immune sera. Transmission electron microscopy of the cultured bacteria demonstrated a typical gram-negative cell wall consisting of an outer membrane, middle electron opaque layer and an inner plasma membrane. The capsule was thick and electron dense. Numerous electron dense granules were present within the cytoplasm.

Azure Stains↗
PubMedDate not supplied

Cytologic detection of cervical granuloma inguinale.

Two cases of granuloma inguinale detected cytologically on routine Papanicolaou-stained cervical smears are presented; the cytologic and histologic features are described in detail, and the electron microscopic appearances are shown. The suitability of the Papanicolaou stain in the detection of granuloma inguinale is discussed, with emphasis on possible differential diagnoses to be considered. It is concluded that a definitive diagnosis of granuloma inguinale can be made on routine Papanicolaou-stained smears showing the following spectrum of changes: intact capillaries indicative of epithelial and stromal ulceration; a marked inflammatory cell infiltrate consisting predominantly of neutrophils; epithelioid histiocytes representing granuloma formation; and Donovan bodies located in characteristic single or multiple intracytoplasmic vacuoles within large histiocytes. Recognition of this cytologic picture may enable early diagnosis, even in nonendemic areas, of a potentially disfiguring venereal disease.

Adult↗
PubMed1979

Status of granuloma inguinale in Papua New Guinea.

Granuloma inguinale has been endemic in Papua New Guinea for at least eighty years and recently appears to be increasing, particularly in the urban centres. Most patients were found to be recent migrants to the Port Moresby area with low socioeconomic status and poor personal hygiene. The disease was found more frequently in males. A possible association between carcinoma of the penis and granuloma inguinale was observed. Lesions were chronic, progressive and located mainly in the genital region. Attempts to culture the causative agent were unsuccessful.

Adolescent↗
PubMed1985

Granuloma inguinale in the eastern Transvaal.

Granuloma inguinale, considered to be a venereal disease, has a world-wide distribution but is more prevalent in tropical and subtropical regions. A number of patients presenting with typical features of this disease, characterized in particular by a beefy-red exuberant appearance of the lesions, have been treated at Shongwe Hospital in Kangwane in the Eastern Transvaal. In 43 of these patients (27 male and 16 female), nearly all in the sexually active age group of 18-41 years, the diagnosis was confirmed by demonstration of typical Donovan bodies. These patients responded well to treatment with tetracycline, but in some the lesions recurred and required further treatment. The chronicity of the lesions should alert the clinician to the possibility of granuloma inguinale, a condition which appears to be more prevalent in this region than previously recognized.

Adolescent↗
PubMed1990

The enigma of granuloma inguinale in South Africa.

Granuloma inguinale (donovanosis) was well described in South Africa in the early part of this century. After 1927 no further reports appeared and with the passage of time, the belief grew that the disease did not occur in this country. This belief held until the 1980s, when several reports of cases of the disease appeared. What happened to the disease in the intervening half century? Did it disappear spontaneously? Or was it just not being recognised even when cases were being reported from 1950 onwards in neighbouring Zimbabwe? How is it that a disease can remain unrecognised when, untreated, it can relentlessly progress to cause severe disfigurement?

Granuloma Inguinale↗
PubMed1997

Granuloma inguinale (donovanosis): an unusual cause of otitis media and mastoiditis in children.

Granuloma inguinale (donovanosis) is seen predominantly in adults (it rarely occurs in children) and mainly affects genital skin and mucosa. Infection occurs at other skin and mucosal sites, and hematogenous dissemination to bone also has been described. The infection responds dramatically to appropriate antibiotic treatment. We present two cases of granuloma inguinale occurring in children (8 months and 5 months of age) causing mastoiditis and external ear discharges. A temporal lobe abscess also developed in the 8-month-old child. Subsequent computed tomography scans showed marked improvement in the brain lesion after treatment. The second child had a polypoid mass in the middle ear that on biopsy showed the features of granuloma inguinale. The mother of this child had biopsy-proven granuloma inguinale of the uterine cervix. These cases indicate that granuloma inguinale can be transmitted during vaginal delivery, and careful cleansing of neonates born to infected mothers is recommended.

Anti-Bacterial Agents↗
PubMed1983

Primary endometrial and endocervical granuloma inguinale (donovanosis). Case report.

Primary endometrial and endocervical granuloma inguinale (donovanosis) was diagnosed in an 18-year-old Melanesian woman in Papua New Guinea. Granulomatous involvement of the parametrium, salpinges, ovaries, and ureters was associated with ureteric obstruction and bilateral hydronephrosis. Granuloma inguinale of the cervix, labia majora, and anus developed after diagnostic endometrial curettage. Treatment with tetracycline and later chloramphenicol had to be stopped because of poor patient compliance. Hysterectomy was performed, after which the patient made a good recovery. This appears to be the first case of primary endometrial and endocervical granuloma inguinale to be reported.

Adolescent↗
PubMed1990

Granuloma inguinale of the cervix: a carcinoma look-alike.

Granuloma inguinale of the cervix presents as a proliferative growth and may mimic carcinoma. Over a 3 year period 18 patients with cervical granuloma inguinale were detected. Nine (50%) had a clinical diagnosis of carcinoma of the cervix on admission, five of whom had extensive investigations to exclude a malignancy. In communities where these two conditions are commonly seen it is recommended that granuloma inguinale be considered in young women with granulomatous lesions of the cervix, so as to avoid extensive and financially costly investigations, and unnecessary psychological stress for patients.

Adult↗
PubMed1979

Granuloma inguinale in Northern Queensland.

Thirteen cases of granuloma inguinale were diagnosed in just over a twelve-month period at the Australian Government Health Laboratory and the General Hospital, Townsville. Seven patients were males, four of whom were immates of Her Majesty's Prison, Townsville. Two of the patients were married, and two were sisters. All the female patients were pregnant at the time of diagnosis. The provisional diagnosis was confirmed by the presence of intracytoplasmic Donovan bodies in crushed tissue smears stained with Wright's stain and pinacyanole. The diagnosis of granuloma inguinale could not be reliably made from sections of formalin-fixed tissue alone. The clinical findings, methods of laboratory diagnosis, management and treatment of this disease are also described with an added emphasis on treatment during pregnancy.

Adult↗
PubMed1989

Lymphogranuloma venereum, chancroid, and granuloma inguinale.

Lymphogranuloma venereum, chancroid, and granuloma inguinale are three uncommon bacterial infections in the United States; however, with the increase in immigrants from Asian and South American countries, the incidence of these infections is rising. This article reviews the clinical manifestations, diagnosis, and therapy of these infections.

Chancroid↗