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At least 19 recordsLinked to original sources
PubMed2004

Improvements in medical care and technology and reductions in traffic-related fatalities in Great Britain.

Great Britain has one of the lowest levels of traffic-related fatalities in the industrialized world with a current total of about 3500 fatalities per year. Large reductions have occurred over the last 20-30 years and the government has targets of achieving another 40% reduction by 2010. This paper analyzes some of the factors that have been statistically significant in helping to achieve those reductions with a focus on improvements in medical care and technology. Using a cross-sectional time-series of regional data a fixed effects negative binomial (NB) model is estimated which includes three proxies of medical care and technology changes. These are the average length of inpatient stay in the hospital, the per-capita level of National Health Service (NHS) staff, and number of people per-capita waiting for hospital treatment. All are statistically significant with the expected sign showing that improvements in medical technology have reduced total fatalities with less of an impact from changes in medical care. Other variables are also found to be significant, including the percent of elderly people in the population, per-capita expenditure on alcohol, motorway capacity, and average vehicle age. The latter shows a surprisingly unexpected effect, with more older vehicles in a region leading to fewer fatalities. Models evaluating effects on serious and slight injuries are also estimated and serve to confirm the expected effects of medical care and technology.

Accidents, Traffic↗
PubMed2006

PrP genotypes of atypical scrapie cases in Great Britain.

Great Britain and elsewhere have detected atypical scrapie infection in sheep with PrP genotypes thought to be genetically resistant to the classical form of scrapie. DNA sequencing of the PrP gene of British atypical scrapie cases (n=69), classical scrapie cases (n=59) and scrapie-free controls (n=138) was undertaken to identify whether PrP variants, other than the three well-characterized polymorphic codons, influenced susceptibility to atypical scrapie infection. Four non-synonymous changes, M112T, M137T, L141F and P241S, were detected that are most probably associated with the A(136)R(154)Q(171) haplotype. Only the PrP variant containing a phenylalanine residue at amino acid position 141 was found to be associated more commonly with the atypical scrapie cases. In addition to the single nucleotide polymorphisms associated with the ARQ allele, two out of nine atypical scrapie cases with the ARR/ARR genotype were found to contain a 24 bp insertion, leading to an additional octapeptide repeat. In terms of PrP genetics, one classification of the GB scrapie cases examined in this study would place animals carrying any homozygous or heterozygous combination of ARR, AHQ or AF(141)RQ alleles, or any one of these alleles when paired with ARQ, as being susceptible to atypical scrapie infection, and animals heterozygous or homozygous for VRQ or homozygous for ARQ as being susceptible to classical scrapie disease. The AHQ PrP allele was associated with the highest incidence of atypical scrapie (263 per 100 000 alleles), whilst VRQ was associated with the lowest incidence (10 per 100 000 alleles).

Alleles↗
PubMed1989

The epidemiology of Echinococcus granulosus in Great Britain. V. The status of subspecies of Echinococcus granulosus in Great Britain.

Twenty-five years ago Williams and Sweatman suggested that in Great Britain there are two subspecies of Echinococcus granulosus--E. granulosus granulosus and E. granulosus equinus. Echinococcus granulosus granulosus does not mature either in foxes or in horses: E. granulosus equinus will mature in either. The prepatent period of E. granulosus granulosus in the definitive host is about 42 days while that of E. granulosus equinus is about 70 days. Each subspecies has a characteristic morphology. More recently, in the course of seven experiments, dogs, red foxes (Vulpes vulpes crucigera), arctic foxes (Alopex lagopus), badgers (Meles meles), domestic ferrets and domestic cats have been infected with protoscoleces derived from hydatid cysts of human, equine and ovine hosts from different regions of England and Wales. Transmissions to horses and sheep were always succeeded by the development of viable hydatid cysts; transmissions to dogs and foxes, by the development of gravid adults. The prepatent period in both dogs and foxes was invariably about 70 days (or longer) and the morphology of all the adult parasites in these definitive hosts was characteristic of E. granulosus equinus. All the evidence derived from these experiments supports the view that there is, in Great Britain, but one subspecies of E. granulosus. That one subspecies is E. granulosus equinus. It infects dogs, red foxes, arctic foxes (experimentally), cats (experimentally), humans, sheep, goats, horses, donkeys, pigs, cattle, roe deer and reindeer (in Scotland). Attempts to transmit E. granulosus to badgers and domestic ferrets were unsuccessful. Of 123 cats infected with protoscoleces of horse origin, one gravid adult parasite was recovered from one animal.

Animals↗
PubMed1989

Improving information on the role of alcohol in interpersonal violence in Great Britain.

In Great Britain, at present, no valid or reliable estimate can be made of the proportion of interpersonal violence caused by alcohol, nor can an assessment be made of the levels of alcohol consumption associated with an increased risk of involvement in interpersonal violence. A critical review of existing British studies and surveillance systems has been undertaken, which indicates that the role of alcohol in interpersonal violence could be defined more precisely, if new and better analytical studies were conducted, if ongoing logitudinal studies and existing surveillance systems were improved or better exploited, and if new surveillance systems were implemented.

Alcoholism↗
PubMed2002

[Interpretation of the increase in bovine spongiform encephalopathy outside Great Britain].

Outside Great Britain, the number of clinical cases of bovine spongiform encephalopathy (BSE) seems to be rising. It is unclear whether this increase is real, or whether it is caused by improved recognition and improved registration of BSE. A strict and independent control of the implementation of measures intended to keep human food free of the BSE agent is imperative.

Animals↗