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At least 19 recordsLinked to original sources
PubMed1999

Optical resolution of glycerin sulfides and glycerin selenides on the chiral stationary phase of cellulose-tris(3, 5-dimethylphenylcarbamate)

Cellulose-tris(3,5-dimethylphenylcarbamate) was prepared after a reported method and was coated onto an aminopropylated mesopore spherical silica gel. The final product was used as a chiral stationary phase of high performance liquid chromatography for the enantioseparation of a series of glycerin sulfides and glycerin selenides. Mixtures of hexane and 2-propanol were used as mobile phases. The effects of 2-propanol concentration in the mobile phase on the retention and resolution were investigated. Some enantiomers of the glycerin monosulfides and monoselenides could be separated satisfactorily, but none of the disulfides could be separated. The structural features of the solutes that influence chiral separation were discussed. Copyright 1999 Wiley-Liss, Inc.

Journal Article↗
PubMed1976

Glycerinated glycol methacrylate mounting medium in highlighting non-coated or glycerin-substituted microsamples under the scanning electron microscope.

Glycol methacrylate hardened with 10-15% glycerin showed no charging and gave dark contrast in the scanning electron microscope with an acceleration voltage of 25kV and a specimen current of 1x10(-10) A. Using human blood cells, it was shown that this conductively treated resin is a useful mounting substrate to highlight the non-coated microsamples or to obtain their highly contrasted images under the scanning electron microscope. It was also demonstrated that the glycerin-substituted blood cells can be scanned with little shrinkage.

Acrylates↗
PubMedDate not supplied

Simple, at-site detection of diethylene glycol/ethylene glycol contamination of glycerin and glycerin-based raw materials by thin-layer chromatography.

This paper describes a rapid, inexpensive thin-layer chromatographic (TLC) method that separates diethylene glycol (DEG) from glycerin and other glycols. Studies with collaborating laboratories of the World Health Organization have shown that about 6% DEG in glycerin and about 2% DEG in acetaminophen (paracetamol) elixirs may be detected by direct visual inspection of the developed TLC sheets. Staining the sheet permits detection of DEG at less than 0.1%. The method costs less than $1.00 per test and takes 20 min by visual inspection, longer when staining is required. The visual method can be performed without laboratory facilities by personnel having little previous training. Samples testing positive by the visual method can be submitted to a laboratory for confirmation and quantitation of DEG.

Acetaminophen↗
PubMed1977

[Mechanism of potentiation of contractions after muslce loading with glycerin. II. Relationship between incubation conditions and obstructing the inflow of glycerin].

A study was made of the influence of glycerol loading on contraction responses of the m. sartorius upon stimulation in normal and calcium-free Reinger solutions by caffeine, tetanic electrostimulation and single electric impulses. It was determined that in the glycerol medium each type of stimulation caused contractility potentiation. Ca2+-ions proved to block the responses of potentiation. The data suggest that there should be a potentiation mechanism common to each type of stimulation.

Animals↗
PubMed1977

[Absorption and metabolism of glycerin in the neonatal period. I. Speed of turnover of glycerin during continuous intravenous infusions in newborn infants of various gestational ages and in older infants].

Glycerol was infused intravenously over 2 hours in preterm and term appropriate-for-date and in term small-for-date infants at the age of 12 to 72 hours and 10 to 14 days and in infants at the age of 3 to 8 months. The dosage was 0.25.kg-1.h-1 and 0.5.kg-1.h-1, respectively. Less than 6 per cent of the glycerol injused were recovered in the urine irrespective of the dosage. The total clearance was 9.1 to 14.6 ml.kg-1. min-1 during the first weeks of life with 0.25 g.kg-1.h-1 glycerol irrespective of gestational age and intra-uterine growth retardation; and it rose to 31.8 ml.kg-1.min-1 in older infants. With 0.5.kg-1.h-1 glycerol the total clearance values were lower in all groups. The glucose blood level and the blood lactate concentration as well as the parameters of the acid-base-balance were not significantly influenced by glycerol.

Acid-Base Equilibrium↗
PubMed2005

Toxicological evaluation of glycerin as a cigarette ingredient.

Glycerin is applied to cigarette tobacco at levels in the range of about 1-5% to improve moisture holding characteristics of tobacco and act as a surface active agent for flavor application. Neat material pyrolysis studies, smoke chemistry and biological activity studies (bacterial mutagenicity, cytotoxicity, in vivo micronucleus, and sub-chronic rodent inhalation) with mainstream smoke, or mainstream smoke preparations from cigarettes containing various target levels (5%, 10%, and 15%) of the glycerin were performed to provide data for an assessment of the use of glycerin as a cigarette tobacco ingredient. The actual levels of glycerin in the respective test cigarettes were determined to be 3.2%, 6.2% and 8.4% after cigarette production. At simulated tobacco burning temperatures up to 900 degrees C, neat glycerin did not pyrolyze extensively suggesting that glycerin would transfer intact to mainstream smoke (smoke was not analyzed for glycerin in this study). On a tar basis, nicotine in smoke was significantly decreased at 10% and 15% glycerin while water was increased at all addition levels. Addition of 10% or 15% glycerin also resulted in a statistically significant increase in acrolein (9%) and a decrease in acetaldehyde, propionaldehyde, aromatic amines, nitrogen oxides, tobacco specific nitrosamines, and phenols. Addition of 5% glycerin produced the same decrease in smoke constituents as the 10% and 15% groups but there was no concomitant increase in acrolein. Biological tests indicated no relevant differences in the genotoxic or cytotoxic potential of either mainstream smoke (or smoke preparations) from cigarettes with added glycerin compared to control cigarettes. Cigarette smoke atmosphere dilution, coupled with the lower nicotine delivery in the test cigarettes containing glycerin resulted in a lower nicotine delivery to the glycerin cigarette smoke exposed rats of the 90-day inhalation study. Smoke atmosphere acrolein was also reduced in a concentration-related manner. Incorporation of glycerin at target levels up to 15% did not produce any adverse effects in rats exposed for 90-days. The major observation in the study was a reduced biological activity of the smoke as indicated by a reduction in the severity and/or incidence of focal macrophage accumulation in the lungs and goblet cell hyperplasia/hypertrophy in the nose (level 1), and goblet cell staining depletion in the nose (level 1). The results of these studies with glycerin applied to cigarette tobacco suggest that adding glycerin to cigarette tobacco at typical use levels does not adversely alter the smoke chemistry or biological effects normally associated with exposure to mainstream cigarette smoke.

Animals↗