[From GIGO (garbage in, garbage out) to KABA (correct disease-relevant consultation, treatment-relevant response)--principles for effective diagnosis of infection].
In the era of cost containment in health care, medical microbiology also faces the challenge of cost-effective use of microbiological diagnostics. However, problems do not arise primarily within the laboratory during analysis of clinical specimens, but also during the pre-analytical stage, i.e. indication, sampling, storing and transporting of microbiological samples. This situation is emphasized drastically by the acronym GIGO, "Garbage In, Garbage Out". To overcome this unsatisfactory situation both clinicians and microbiologists have to improve communication and collaboration which is the basis for the rational diagnosis of infection and therapy. Examples of inadequate microbiological investigations together with the correct use of blood cultures are given.