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At least 19 recordsLinked to original sources
PubMed1998

Proliferative activity in peripheral ossifying fibroma and ossifying fibroma.

A proliferative activity study analysing morphometric and quantitative aspects of nucleolar organizer regions (NORs) and proliferating cell nuclear antigen (PCNA) expression was conducted in 10 cases of peripheral ossifying fibroma (POF) and 10 cases of ossifying fibroma (OF). For NOR identification, the silver staining technique (AgNOR technique) was used. PCNA expression was determined by immunohistochemical staining using the PC10 antibody. The AgNOR analysis for the two lesions showed a profile characteristic of benign lesions. OF showed higher AgNOR number and PCNA expression than POF. Our results suggest increased proliferative activity in OF compared with POF.

Antibodies, Monoclonal↗
PubMed1977

Long bone ossifying fibromas.

Ossifying fibromas involving the tibia were seen in two patients. In both patients, the radiographic appearance of the lesions suggested fibrous dysplasia, but histopathologic evaluation demonstrated findings similar to ossifying fibroma of the mandible and facial bones. Radiologic and pathologic recognition of this entity is necessary for proper treatment.

Adolescent↗
PubMed2005

Frontal sinus cementifying ossifying fibroma.

Cementifying ossifying fibroma is a fibro-osseous lesion which produces cementum. Cementifying ossifying fibroma is a mesodermal, non-odontogenic tumor of ectopic multipotential periodontal membrane blast cells. Although, it is a benign bone tumor, it has an aggressive destructive behavior in patients under 20 years of age with high tendency for recurrence. Cementifying ossifying fibroma can be recognized microscopically by the presence of cementicles. This is a case of frontal sinus cementifying ossifying fibroma presenting with proptosis in a 39-year-old male.

Adult↗
PubMed2006

An immunohistochemical evaluation of BMP-2, -4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva.

The present study examined histological difference between ossifying fibromas (OF, n=5) and peripheral cemento-ossifying fibromas (PCOF, n=7). Bone morphogenetic proteins (BMP)-2 and -4, osteopontin (OPN), osteocalcin (OCN) and proliferating cell nuclear antigen (PCNA) were used for the immunohistochemical examinations. Oxytalan fibers present at the periodontal tissue were stained to determine the tumor cell origin. Many OFs showed high immunohistochemical reactions for BMP-2, -4 and OPN compared to those of PCOFs. PCNA index (IP) of OFs was significantly higher than that of PCOFs. All the PCOFs showed a high expression of oxytalan fibers. Only two OFs exhibited a small number of oxytalan fibers. These results suggest that PCOF has only little ability to form hard tissue and seems to be a reactive lesion. The expression of oxytalan fibers reveals that OF does not only originate from periodontal tissue.

Adolescent↗
PubMed2006

A case of frontal lobe abscess as a complication of frontal sinus ossifying fibroma.

Sinonasal ossifying fibroma is a rare, slow-growing, benign bony tumour, frequently involving the maxilla and mandible in the head and neck region. Although it is known to be the second most frequent fibro-osseous tumour of paranasal sinus, to the best of our knowledge, ossifying fibroma of frontal sinus causing brain abscess has not been presented yet in the relevant literature. We present the clinical, pathological and radiological findings of ossifying fibroma of the frontal sinus associated with brain abscess.

Brain Abscess↗
PubMed1993

Psammomatoid ossifying fibroma of the paranasal sinuses. An extragnathic variant of cemento-ossifying fibroma. Report of three cases.

Psammomatoid ossifying fibroma (POF) is a diagnostic designation for a sinonasal or orbital fibroosseous lesion characterized by numerous small round mineralized spherules lying in a fibroblastic stroma. We report 3 cases. One occurred in the frontal sinus of an 18-years-old male; 1 in the frontal sinus of a 20-year-old male and 1 in the maxillary sinus of a 36-year-old male. Rather limited excision resulted in a disease-free follow-up time from 2 to 6 years. The histomorphology of POF was compared with other fibro-osseous lesions of the craniofacial skeleton including the jaws. It appeared that POF is similar to cemento-ossifying fibroma occurring in the jaws and the necessity for different names for lesions only differing in their site of occurrence is considered to be at least debatable.

Adolescent↗
PubMed2002

Sublabial approach to sinonasal juvenile ossifying fibroma.

Juvenile ossifying fibroma is a rare, unusual fibro-osseous benign tumor of the craniofacial region. It is a progressively growing tumor and has to be removed completely to prevent recurrence. A radical surgery is not advisable in a pediatric patient. Here we describe the sublabial approach for excision of this tumor that allows the complete removal of the tumor without compromising with the aesthetic looks of the patient.

Bone Neoplasms↗
PubMed2006

Multicentric peripheral ossifying fibroma.

Peripheral ossifying fibroma (POF) is a common solitary gingival growth thought to arise from the periodontal ligament. Though the etiology of POF remains unknown, some investigators consider it an inflammatory or reactive process, while others suggest it is a neoplastic process. In this report, we present and discuss a unique case of multicentric POF, affecting the maxillary and mandibular gingiva of a 49-year-old Caucasian female with meticulous oral hygiene and routine dental care. Though biopsy samples from multiple sites revealed similar histopathologic features, consistent with POF, the fact that there was a multicentric presentation is a unique phenomenon for this lesion. Multicentric lesions presenting in the oral and maxillofacial region are not typical, but have been observed in conditions associated with known genetic mutations, such as nevoid basal cell carcinoma syndrome (multiple odontogenic keratocysts), multiple endocrine neoplasia type II (multiple neuromas), neurofibromatosis (multiple neurofibromas) and Gardner syndrome (multiple neoplasms). This case is the first one to demonstrate that there may be a multicentric variant of POF that has not been previously recognized, and given the clinical presentation and multifocal nature of disease, the lesions in this patient are likely the result of genetic mutation(s) that predisposes to gingival soft tissue overgrowths containing mineralized product.

Female↗
PubMed2003

Psammomatoid ossifying fibroma.

Psammomatoid ossifying fibroma (POF) represents a unique subtype of fibro-osseous lesions. We describe a case of POF involving the orbit and the sinonasal tract, in a 13-year-old white female. Diagnosis depends on the histological, radiological and clinical features. Complete excision by endoscopic nasal surgery was the treatment of choice. Five years later the patient was free from symptoms and tumour recurrence. Differential diagnoses are discussed.

Adolescent↗
PubMedDate not supplied

Cemento ossifying fibroma.

Cemento ossifying fibroma is a benign, non odontogenic tumour of the jaw, a subdivision of fibro-osseous lesions. The age of occurrence is between 20 and 40 years. It has a female to male predilection of 2:1. A rare case of cemento ossifying fibroma involving maxilla and mandible in a 30 years old female is presented with a discussion on its clinical and radiographical features, computed tomograph scan findings, histopathological presentation with a review of literature.

Adult↗
PubMedDate not supplied

Managing a peripheral ossifying fibroma.

The Peripheral Ossifying Fibroma is an inflammatory lesion which most often appears in twenty-five to thirty-four-year-old females. It averages 1.0 cm at its greatest dimension. This case reports a seven-year-eight-month-old female who presented with a peripheral ossifying fibroma lesion which measured 2.7 cm by 1.5 cm by 1.0 cm. A review of peripheral ossifying fibroma, and the management and postsurgical sequelae of this child are discussed.

Child↗
PubMed2004

Familial ossifying fibromas: report of two cases.

Ossifying fibroma is a benign fibro-osseous lesion of the jaw containing varying amounts of calcified deposits such as bone, cementum or both. This type of lesion is referred to as dysplastic or neoplastic in nature. In 2000, a 52-year-old male patient was referred to our clinic complaining of a giant swelling in the mandibular premolar-molar region. A histopathological diagnosis of ossifying fibroma was made. Three months later, his daughter was admitted with a swelling on her mandible. Following biopsy, this patient was also diagnosed as having ossifying fibroma. The present report describes these two cases of familial and multiple ossifying fibromas.

Adult↗
PubMed2006

HRPT2 gene alterations in ossifying fibroma of the jaws.

Ossifying fibroma (OF) is a benign neoplasm related to bone characterized by a progressive enlargement of the affected jaw. Recently, the candidate tumor suppressor gene HRPT2 was identified and alterations in this gene were related with the Hyperparathyroidism-jaw tumor syndrome that is characterized by parathyroid adenoma or carcinoma, fibro-osseous lesions (mainly OF) of the jaws, and renal lesions. The purpose of the present study was to evaluate the HRPT2 gene in OF. Tumour and blood samples were obtained from 3 patients with OF and one with juvenile ossifying fibroma (JOF). The results demonstrated three novel mutations in two out of three genotyped OF's. Interestingly, one of these patients showed a germ-line mutation after blood analysis. RT-PCR amplification was performed to analyze HRPT2 mRNA expression and only wild-type HRPT2 transcript was found in all tumours. Investigation of the parafibromin protein by immunohistochemistry showed a similar pattern of immunolocalization with strong nuclear and cytoplasmic staining in all cases. In conclusion, the present study shows for the first time mutations of HRPT2 gene in OF and suggests that OF may arise due to haploinsufficiency of the HRPT2 gene.

Adolescent↗
PubMedDate not supplied

Ossifying fibroma. A case report.

Ossifying fibroma is a benign tumor of connective tissue origin which occurs in fibro-osseous lesions. The lesion is seen most commonly in children and young adults. It is asymptomatic and slow-growing, but in some cases may show aggressive behavior. Though it has a slight predilection for the mandible, it may involve both jaws. The lesion is generally asymptomatic until it produces noticeable swelling, and mild deformity and migrations of teeth may be an early clinical feature. Pediatricians and dentists must be aware when asymmetry of the face occurs, and the lesion must be well diagnosed as it has a cancer-like radiographic appearance. In this article a nine-year-old patient with a massive mandibular ossifying fibroma is presented.

Child↗
PubMed2001

Long-term follow-up of peripheral ossifying fibroma: report of three cases.

Peripheral ossifying fibroma is a non-neoplastic enlargement of the gingiva that is classified as a reactive hyperplastic inflammatory lesion. It is possible to misdiagnose peripheral ossifying fibroma as pyogenic granuloma, peripheral giant cell granuloma, or odontogenic tumors. Therefore, histopathological examination is essential for an accurate diagnosis of such lesions. Differential diagnosis is important, because peripheral ossifying fibroma has a tendency to recur. This article describes three cases of peripheral ossifying fibroma, which were followed for 4 years without any sign of recurrence. By presenting these cases, we emphasize the importance of proper excision and aggressive curettage of the adjacent tissues for prevention of recurrence.

Adolescent↗
PubMed1999

[Clinical analysis of 12 cases of long bone ossifying fibromas].

Twelve cases of ossifying fibroma of long bones, the lesions in 11 cases were resected with their sclerotic margin. Inactivation of the tumor cells within bone cavity was applied 50% Zinc Chloride, and autogenous bone grafts were applied with or without a few man-made bones. One case was treated by en bloc resection of the lesion. Follow-up for 3-14 years revealed that 2 cases recurred, and secondary operation was performed. After that follow-up for 5-14 years revealed no-recurrence. Recurrence rate of these cases was low and the effect of treatment was satisfactory. This kind of lesion showed the features of its aggressive growth and proneness to recur after operation. The authors consider that resection of the lesion including its sclerotic margin was effective to prevent recurrence.

Adolescent↗