[Idiopathic femur head necrosis].
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The authors present a description of two observations over patients with aseptic necrosis of the heads of the femur in Itsenko-Cushing's disease. A short literature survey is given, and an opinion is put forward that not only osteoporosis, but also other factors (thrombosis, vasculitis, and others) underly the lesion pathogenesis.
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Aseptic necrosis of bone is a known complication of corticosteroid therapy. We report a case of aseptic necrosis of the femoral head as a presenting symptom of Cushing's disease. The case demonstrates that endogenous steroids, like exogenous steroids, may bear the same relationship to the pathogenesis of aseptic necrosis of bone. It also indicates that Cushing's disease must be considered in every case of so-called idiopathic aseptic necrosis of bone.