Skeletal lesions following ingestion of fluoridated water.
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Hens were treated with organophosphorus compounds until signs of neurotoxicity developed. The sciatic nerves, spinal cord, and medulla were then examined histologically by the Marchi method, to determine the extent and distribution of demyelination. The lesions were proportional to the dose of compound injected, and the spinal cord was more sensitive than the sciatic nerves. It is suggested that the spinal cord, and not the sciatic nerves, is the main site of damage in clinical paralysis following dyflos poisoning.
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Results of an experiment designed to test the effect of chloride ion concentration on fluoride toxicity to rainbow trout (Salmo gairdnerii) indicated that tempering fish to chloride reduced their response to fluoride.
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