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Results for “FAIR”

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At least 19 recordsLinked to original sources
PubMed2026

Fairness-aware supervised hierarchical contrastive semantic learning for sexual dimorphism analysis.

MOTIVATION: Sexual dimorphism is a fundamental biological determinant driving systematic differences in disease susceptibility, progression, and clinical outcomes. However, current sex-combined AI-based genomic models often exhibit algorithmic bias and fail to capture these sex-specific mechanisms, creating a critical barrier to unbiased precision medicine. Ensuring fairness in the context of sexual dimorphism requires understanding and addressing the distinct biological mechanisms functioning in each sex, rather than focusing solely on equalizing predictive performance. RESULTS: We propose a fairness-aware supervised hierarchical contrastive learning approach, called FairHICON, to discover unbiased sex-common and sex-specific predictive features. Evaluations on cancer and asthma transcriptomic datasets demonstrate that FairHICON significantly outperforms state-of-the-art benchmarks, improving predictive performance by up to 9% while effectively reducing the performance gap between male and female sexes. Furthermore, prognostic validation confirms that the identified sex-specific pathways stratify patient survival significantly better within their corresponding sex groups. This validates FairHICON to elucidate the molecular heterogeneity of sexual dimorphism, advancing inclusive precision medicine. AVAILABILITY AND IMPLEMENTATION: The source code and data is available at https://github.com/datax-lab/FairHICON.

Sex Characteristics↗
PubMed1975

Patient rehabilitation through hospital work under Fair Labor Standards.

Payment of patients for hospital work assignments has become a matter of great concern for mental health institutions since the 1973 federal court ruling requiring the Department of Labor to enforce the 1966 amendments to the Fair Labor Standards Act. A work program in compliance with Fair Labor Standards has been operating at Binghamton (N.Y.) Psychiatric Center since 1971. Certificates from the labor department permit the hospital to pay less than the minimum wage for patients in occupational training or in sheltered employment in a regular job. The authors believe that work therapy has important clinical and rehabilitative functions, and that patients should not be denied the opportunity for such work because of the court ruling.

Persons with Disabilities↗
PubMed1979

How fair is the culture I.Q. test?

If a measure of intelligence is culturally biased it is assumed that disadvantaged individuals will score lower on it than on a less biased instrument. The Cattell purports to be "culture fair" and it was compared to the WISC with a delinquent juvenile population, controlling for both order effects and individual administration. The results reveal consistently lower mean I.Q. scores for the Cattell under all conditions. The Cattell appears to be a more difficult test for this population. It is concluded that considerable caution should be exercised inusing the Cattell as a culture fair method of I.Q. evaluation with underprivileged delinquent youth.

Cultural Deprivation↗
PubMed2025

Microbiology Galaxy Lab: The first community-driven gateway for reproducible and FAIR analysis of microbial data.

The explosion of microbial omics data has outpaced the ability of many researchers to analyze it, with complex tools and limited computational resources creating barriers to discovery. To address this gap, we present the Microbiology Galaxy Lab: a free, globally accessible, community-supported platform that combines state-of-the-art analytical power with user-friendly accessibility. Supported by the Galaxy and global microbiology communities, this platform integrates over 315 tool suites and 115 curated workflows, enabling comprehensive metabarcoding, (meta)genomic, (meta)transcriptomic, and (meta)proteomic data analysis within a FAIR-aligned environment. It also supports research in the health and infectious disease sectors, as well as in environmental microbiology. The platform's utility is exemplified through various use cases, including antimicrobial resistance tracking, biomarker prediction, microbiome classification, and functional annotation of key microbes. Built on reproducibility and community engagement, it supports creation, sharing, and updating of best-practice workflows. Over 35 tutorials and learning paths empower scientists, fostering an ecosystem that keeps resources at the forefront of microbial science. The Microbiology Galaxy Lab enables collective analysis, democratising research, thereby accelerating discovery across the global microbiology community (microbiology.usegalaxy.org, .eu, .org.au, .fr).

Journal Article↗
PubMed1976

Patient work under Fair Labor Standards: the issue in perspective.

The 1973 federal court ruling in Souder v. Brennan required that patient workers in institutions for the mentally ill and mentally retarded be paid in accordance with the minimum wage and other provisions of the Fair Labor Standards Act. The author believes that ruling, which ran contrary to widely accepted institutional practices, is more readily understandable when viewed in the broader context of wage-and-hour legislation. He presents a brief history of the legislation, discusses the provisions relating to the employment of handicapped workers included in the 1966 amendments, and emphasizes that one basic principle underlies all the regulations and procedures: a patient must be paid what he earns. He also urges increased attention to the clinical design of compensated work systems to promote therapeutic and rehabilitative objectives.

Persons with Disabilities↗
PubMed2025

Fundamentals of FAIR biomedical data analyses in the cloud using custom pipelines.

As the biomedical data ecosystem increasingly embraces the findable, accessible, interoperable, and reusable (FAIR) data principles to publish multimodal datasets to the cloud, opportunities for cloud-based research continue to expand. Besides the potential for accelerated and diverse biomedical discovery that comes from a harmonized data ecosystem, the cloud also presents a shift away from the standard practice of duplicating data to computational clusters or local computers for analysis. However, despite these benefits, researcher migration to the cloud has lagged, in part due to insufficient educational resources to train biomedical scientists on cloud infrastructure. There exists a conceptual lack especially around the crafting of custom analytic pipelines that require software not pre-installed by cloud analysis platforms. We here present three fundamental concepts necessary for custom pipeline creation in the cloud. These overarching concepts are workflow and cloud provider agnostic, extending the utility of this education to serve as a foundation for any computational analysis running any dataset in any biomedical cloud platform. We illustrate these concepts using one of our own custom analyses, a study using the case-parent trio design to detect sex-specific genetic effects on orofacial cleft (OFC) risk, which we crafted in the biomedical cloud analysis platform CAVATICA.

Cloud Computing↗
PubMedDate not supplied

[Medical equipment at the Leipzig Fall Fair, 1978].

This is an attempt to reveal the main directions and trends in the medical technique progress, as evidenced by the most interesting exhibits at the 1978 Autumn Leipzig Fair. Advantages of the functional-block designing method were noted, seen in the instruments made for clinical diagnostic laboratories. Promising features are emphasized, intrinsic for units intended for reconstructive X-ray tomography, autoanalysers for studying blood, enzymes and substrates, as well as for ultrasonic diagnostic devices. The latter provide a combination of A and B-mode echography, or the M-type scanning with Doppler ultrasonic pulse investigation. Such a combination allows to fix on the echogram the precise position of the structure being investigated by the Doppler approach.

Exhibitions as Topic↗
PubMedDate not supplied

[Medical equipment at the Leipzig Fall Fair of 1977].

An analysis of the most interesting exponents of the Leipzig autumn fair of 1977 served as a groundwork for an attempt to outline the major orientation and trends in the development of the biomedical engineering. The advantages of the functional units method of designing are taken notice of on an example of some groups of devices manufactured both in the countries members of the Council for Economic Mutual Assistance and in western countries. Emphasis is placed on the good prospects offered by medical devices for ultrasonic location of the heart with the type M scanning, of the X-ray units intended for solving concrete diagnostic objectives within a narrow branch of medicine (apparatus for mammography, for use in urology, etc). Particular attention is paid to the medical equipment utilizing the elements of computer technique, in the form of built-in units and also in that of complex setups in which small computers ensure the most effective realization of the diagnosis and treatment.

Dental Equipment↗
PubMed1978

Medical students, practitioners hold health fair at high school.

This health fair provides a model for introducing health care into a poor, urban, underserved community. Medical students, practitioners, health care institutions, school officials, and local businesses cooperated to provide a program that included physical examinations, educational sessions, entertainment, and information on health careers, especially for young people from "minority groups."

Adolescent↗
PubMed1979

Has myelin basic protein received a fair trial in the treatment of multiple sclerosis?

Autosensitization to some central nervous system antigen still remains one of the best hypotheses for the continuing pathogenesis of multiple sclerosis (MS). Enough is now known about the cause, pathogenesis, and treatment of experimental allergic encephalomyelitis (EAE) to test this hypothesis. Reports of therapeutic failure of the encephalitogen myelin basic protein (BP) in the treatment of MS have their counterparts in similar therapeutic failures in EAE. Only highly inbred strain 13 guinea pigs respond consistently to BP therapy, and this only when BP is administered in relatively high doses. Noninbred guinea pigs respond much less well to simple BP therapy, and monkeys hardly at all. In both strains of monkeys so far studied, a nonspecific adjunctive factor--an antibiotic in Macaca mulatta and a steroid in Macaca fascicularis--is also required. Accordingly, human trials of the therapeutic efficacy of BP in MS should include its administration in large concentrations together with an adjunctive agent.

Adjuvants, Immunologic↗
PubMed1979

Mandibular reconstruction and craniofacial fairing.

A method of restoring bony contour defects in the craniofacial regions employing a combination graft of autogenous bone and an alloplastic mesh is presented. Osteoinduction occurs within the confines of the alloplastic mesh from the cancellous bone and the resultant new bone conforms to the outline imposed by the alloplastic device. The advantages of this method include those of alloplastic materials combined with those of bone grafting. There is immediate restoration of an aesthetic contour with adequate strength and sound fixation.

Adolescent↗
PubMed2026

The INSDC specifications-foundations for a FAIR and global INSDC.

Members of the International Nucleotide Sequence Database Collaboration (INSDC; https://www.insdc.org/) collect, exchange, and preserve comprehensive open nucleotide sequence information and provide tools for its access. The INSDC has stated its commitment to welcoming new members into the collaboration to be more representative of the global community of data and users. To reach this goal, a comprehensive definition of the INSDC data model and minimum requirements for data acceptance have been established. Here we describe the processes used to arrive upon these INSDC Specifications and lay out strategies for their continued upkeep to remain current and relevant. Database URL:  https://www.insdc.org/.

Databases, Nucleic Acid↗
PubMed2026

Pithos - a scalable and secure data container for FAIR-compliant research data management in life sciences.

Modern research techniques have led to exponential growth in the volume and complexity of scientific data. Consequently, managing these volumes securely and efficiently has become a major challenge. While all research domains face these challenges, life science research is particularly affected because current approaches often rely on a large set of different file formats, with metadata stored in separated databases or spreadsheets. This leads to fragmented datasets, orphaned data, and compromised research reproducibility. Traditional solutions also force researchers to choose between security and accessibility, with encrypted files preventing selective access and indexed formats lacking adequate security for sensitive data. These limitations are particularly problematic in large-scale genomic studies where researchers must decompress multi-gigabyte files to access specific regions, creating computational bottlenecks and inefficient network usage when working with cloud-stored datasets. We introduce Pithos, a next-generation file format specifically designed for scientific data management in distributed cloud environments. The format uses content-defined chunking to enable efficient deduplication across distributed storage systems, thereby reducing storage costs and bandwidth requirements. The append-only structure ensures data immutability and allows for incremental updates without compromising content. Benchmark results show that Pithos outperforms existing solutions in read and write performance, with comparable or improved storage efficiency.

Biological Science Disciplines↗
PubMed1978

An evaluation of the utility of high blood pressure detection fairs.

Our data indicate that voluntary casual screenings in essentially middle class locations may be of limited value in attracting the young, the black, and the male relative to the target population. Our screens attracted a large proportion of individuals who where already aware of their high blood pressure. Nevertheless, these screens can be useful in getting and keeping individuals under medical care: newly detected hypertensives, those who knew they have it and even some of those under treatment for it.

Evaluation Studies as Topic↗