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Results for “Eyelid Neoplasms”

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At least 19 recordsLinked to original sources
PubMed1975

Eyelid neoplasms of dogs.

A survey of 202 canine eyelid neoplasms was conducted to identify the prevalence of tumor types and their biological behavior. Sebaceous gland tumors, melanomas, and papillomas made up 82.1% on neoplasms studied. Sebaceous tumors were most frequently encountered, comprising 44% of canine eyelid tumors. Benign tumors (75.3%) were more prevalent than malignant forms (26.7%), and epithelium tumors outnumbered those of mesenchymal origin 134 to 23. A slightly higher percentage of neoplasms were removed from upper eyelids (40.2%) than from lower eyelids (30.2%). The average age of dogs with eyelid tumors was 8 years. Malignant tumors were comparatively larger than benign forms, but metastasis of eyelid tumors was not observed.

Adenocarcinoma↗
PubMed1982

The management of eyelid neoplasms.

The results of 377 patients treated for eyelid neoplasms are reported. A definitive histological diagnosis is essential before commencing treatment. Basal cell carcinomata were the commonest lesions encountered in this series. The various indications for radiotherapy, surgery and cryotherapy are discussed and their respective advantages and disadvantages considered. The aim of treatment is a cure of the primary condition and a satisfactory cosmetic result with the minimum of complications. In this Unit surgery is reserved for a simple excision biopsy or diathermy excision and Wolfe graft as radiotherapy appears to offer the best form of treatment in most cases.

Basal Cell Carcinoma↗
PubMed2005

"Pseudo-pseudochalazion": giant chalazion mimicking eyelid neoplasm.

A 33-year-old man presented with a solid lesion encompassing the entire left upper eyelid. Multiple biopsies revealed lipogranuloma consistent with chalazion. The induration resolved after multiple triamcinolone injections. This is the only case report to our knowledge of a chalazion that involved the entire upper eyelid.

Adult↗
PubMed2005

The expression of P53 protein and infection of human papilloma virus in conjunctival and eyelid neoplasms.

Human papilloma virus (HPV) infection and loss of P53 function have been identified as frequent events in various human tumors. The aim of this study was to evaluate P53 protein expression and to detect HPV in the tissue samples of 45 benign (papillomas) and 38 malignant conjunctival and eyelid lesions (27 basal cell carcinomas and 11 squamous cell carcinomas). We also looked for eventual relationships between P53 expression and clinicopathological features such as age, histological type of tumor, grading and staging. HPV infection was detected using the PCR-RFLP method. Specific primers were engaged and PCR products of HPV 16, 18, and 33, underwent enzymatic digestion at 37 degrees C. We revealed P53 protein expression in 30 out of 45 (66.6%) squamous cell papillomas. In the SCC and BCC groups, P53 was present in 31 out of 38 carcinomas and there was a statistically significant correlation between histological type of tumor and P53 protein expression. Malignant type HPV 16 and 18 were detected in three squamous cell papillomas, two BCCs and one SCC. However, we observed P53 protein expression in only two HPV-positive papillomas and one infiltrative type of BCC. P53 is probably involved in the development of conjunctival and eyelid tumors due to its high rate of presence in both benign and malignant neoplasms of these organs. HPV seems to occur rarely. In some cases its role in the pathogenesis of conjunctival and eyelid tumorigenesis should be considered as auxiliary.

Adult↗
PubMedDate not supplied

[Surgical treatment of eyelid neoplasms with regard to reconstructive methods].

Results of surgical treatment of lid neoplasms, taking into account cosmetic effects are presented. The age of patients ranged from 28-78 years, with 58% above 60; 69% of them were males. The choice of surgical method depended on the advancement of the neoplasms, their localization and the age of patients. During 2-year follow-up no recurrence was observed and the functional and cosmetic results of treatment were satisfactory.

Adult↗
PubMed1996

The individual versus the statistical patient: relationships between treatment of malignant eyelid neoplasms and their "Hosts".

The essence of the doctor-patient interaction is that of a caring relationship. Too often, our reliance upon data, statistical analysis, and out-come percentages obscure the need for subjective interpretation of each healing interaction in which we are engaged. Awareness and responsiveness, on personal and professional levels, to the intuitive and sacred aspects of the doctor-patient relationship need to be recognized as being as important as the rational and scientific aspects of treatment and management if we are to be healers in the fullest sense.

Adult↗
PubMed1977

Meibomian gland carcinoma seeding intracranial soft tissues.

Meibomian gland carcinoma is a rare sebaceous gland malignant tumor of the eyelid. Local recurrence and regional lymph node metastases are common among this group of eyelid neoplasms. Distant liver metastases have been mentioned in one case report, but this represents and unusual finding. In addition to local recurrence and regional lymph node metastases, this autopsy case report demonstrates meibomian gland carcinoma with extension to the trigeminal ganglia and metastases to the cerebellum.

Adult↗
PubMedDate not supplied

Treatment of eyelid epithelial neoplasm by targeting sonic hedgehog signaling: an experimental study.

PURPOSE: To evaluate the effect of cyclopamine, an inhibitor of the Sonic hedgehog (Shh) signal, on the growth of an epithelial neoplasm. METHODS: Chemically induced eyelid tumors in XPC-null mice (n=40) were treated daily with a subcutaneous injection of cyclopamine (1 mg/animal) for 7 days. The animals were killed after bromodeoxyuridine (BrdU) labeling, and the tumors were histologically examined. An in vitro study was conducted by using a squamous cell carcinoma (SCC) cell line. The SCC cells were treated with 0, 12.5, or 25.0 microg/ml recombinant Shh (rShh) and either 0 or 100 microM cyclopamine, and cell proliferation was evaluated by using an MTT assay. Cells from this cell line were also implanted subcutaneously in nude mice (n=8) to develop tumors, and the effect of cyclopamine administration was examined in the developed tumors. RESULTS: Histology showed that cyclopamine treatment suppressed BrdU incorporation and induced apoptosis in the majority of cells in tumors chemically induced in the eyelid of the XPC-null mice. Cell proliferation of the SCC cell line was enhanced by adding rShh, and this effect was abolished by adding cyclopamine. Proliferation of the SCC cell line was not affected by adding cyclopamine in the absence of rShh. On the other hand, the SCC cells expressed Shh in vivo in tumors developed in nude mice, but cyclopamine suppressed cell proliferation in the tumors, and the Shh-signaling pathway was inhibited by cyclopamine-induced apoptosis. CONCLUSIONS: Cyclopamine inhibits proliferation and induces apoptosis in epithelial tumor cells in vivo. The Shh-signaling pathway may be a potential therapeutic target for patients with eyelid tumors.

Animals↗
PubMed1978

An unusual case of metastatic carcinoma to the eyelid.

A 46-year-old woman developed a painless nodular lesion of her right lower eyelid four years after having a right radical mastectomy for breast carcinoma. The lesion slowly increased in size over one year to involve full thickness eyelid tissue that included the margin and inferior punctum and was associated with localized loss of cilia. The clinical appearance of the lesion and its course of development suggested a primary eyelid neoplasm. Incisional biopsy revealed metastatic mammary carcinoma.

Breast Neoplasms↗