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At least 19 recordsLinked to original sources
PubMed1989

[Animal welfare relevance and the functional and morphological significance of the killing of laboratory animals].

Euthanasia of experimental animals at the end of an experiment or when an experiment is terminated is relevant for two reasons: firstly, because of ethical reasons and of animal protection, secondly because of scientific evaluation of experimental results. Functional and morphologic alterations have up to now been inadequately observed and considered. Gradually varying different results depend on the different methods of euthanasia. Additionally single parameters of reactions in isolated organs vary depending on the method of euthanasia. These facts have not yet been respected in the discussion of so called alternate methods. The significance of functional and morphologic effects as seen in different methods of euthanasia is discussed with examples.

Animal Welfare↗
PubMed2003

[Euthanasia of pregnant animals].

For euthanasia of pregnant animals, a rapid and painless death is essential. The technique of euthanasia should minimize stress and anxiety experienced by the animal so far as possible. The death is induced by an anoxia in the central nervous system or by a pharmacologic inhibition of essential neuronal functions. Pentobarbital is the best suited drug for euthanasia of animals and especially of pregnant animals. Combinations with muscle relaxing agents should not be used because of possible apnoe without unconsciousness.

Animals↗
PubMed1986

Euthanasia of food animals.

Humane euthanasia is considered to be the rapid and painless inducement of death. It is necessary for unconsciousness to occur quickly and be followed immediately by cardiac and/or respiratory arrest. Although many methods of euthanasia have been used, not all fulfill the criteria of humane euthanasia. Methods of euthanasia used in food animals are presented and evaluated as to their appropriateness.

Animal Welfare↗
PubMed1977

[Botulism in a number of yearlings (author's transl)].

An outbreak of botulism in four yearlings of a single herd is reported. One animal recovered spontaneously. The other animals underwent euthanasia (animal A) or were slaughtered (animals B and C). Cl. botulinum toxin type C was detected in the sera of animals A and B as well as in the liver and abomasal contents of animal A. In addition, Cl. botulinum was isolated from the liver of animal A. The symptoms are described. Total muscular weakness, also resulting in lingual paralysis and inability to swallow, was the most important clinical feature. The mechanism of action of Cl. botulinum toxin, possible methods of treatment and aspects of meat inspection are discussed.

Abomasum↗
PubMed1978

Effect of rapid decompression and associated hypoxic phenomena in euthanasia of animals: a review.

Documentation in the literature indicates that death is as painless following the induction of hypoxia by rapid decompression as by other methods that lead to hypoxia, such as exposure to high altitude, carbon monoxide, and inert gases (nitrogen, xenon, and krypton). Many of the signs and symptoms of hypoxia are the same as those for alcoholic intoxication and inert gas narcosis. Moreover, there is good evidence that analogous relationships or mechanisms may exist for hypoxia, inert gas narcosis, and anesthesia.

Alcoholic Intoxication↗
PubMed2000

Radioactive waste minimization implications of clinically-indicated exsanguination procedures.

Exsanguination is a method of animal euthanasia approved for use in specific circumstances. Animals undergoing exsanguination are fully anesthetized, and the blood is removed resulting in hypovolemia. In situations where radioactive materials are used as part of a research protocol that remain predominantly suspended in the blood, the exsanguination procedure can result in a significant lowering of residual radioactivity content. This reduction can greatly affect the types of waste management and minimization options that can be subsequently applied. In this study, data were collected from 20 rabbits injected with approximately 29.6 MBq (0.8 mCi) of tritiated thymidine as part of a percutaneous transluminal carotid artery angioplasty study. Residual concentrations of radioactivity were consistently reduced by an average of 88%. The reduction was very significant in this instance, since the residual activities were below the established exemption limit of 1.85 kBq g(-1) (0.05 microCi g(-1)) for disposal of these wastes as non-radioactive. Although the exsanguination procedure can result in significant waste minimization opportunities in certain circumstances, this should not be the rationale for its use. Rather, the method of euthanasia should be based exclusively on sound animal care and use principles, and waste management strategies should then be made following that decision. Health Phys. 79(3):291-293; 2000 Key words: waste, low-level; waste management; radiation protection; blood

Animals↗
PubMedDate not supplied

Method of euthanasia does not affect sperm motility in the laboratory rat.

To determine if anesthetic agents used in laboratory animal euthanasia affected sperm motion parameters, rats (n = 10 per group) were euthanized by one of 5 different methods: decapitation alone, or decapitation following either ether, halothane, or Nembutal anesthesia, or CO2 asphyxiation. Sperm were collected from the distal cauda epididymis, diluted, and videotaped for computer-aided sperm analysis (CASA; HTM-2030, Hamilton-Thorn Research, Beverly, MA). The percentage of motile sperm (MOT), their straight-line velocity (VSL), average path velocity (VAP), curvilinear velocity (VCL), linear index (LINX), and linearity (LIN) were measured on > or = 200 motile sperm per sample. No significant differences in any of these 6 motion parameters were found among the treatment groups. Thus, none of these 5 methods of euthanasia affect sperm motion as assessed by CASA methods, making them equally suitable for use in reproductive toxicology studies.

Anesthesia↗
PubMed1995

Immunolocalization of endothelin in the traumatized spinal cord: relationship to blood-spinal cord barrier breakdown.

The purpose of this study was to determine the relationship between endothelin-1 (ET-1), a prominent vasoactive agent, and the breakdown of the blood-spinal cord barrier along the axis of the cord after a moderate spinal cord injury. In the first study rats (n = 10) were euthanized 24 h after spinal cord injury and compared to sham (n = 5) and unoperated (n = 10) controls. Endothelin and immunoglobulins (IgG) were immunolocalized in adjacent sections of spinal cord using semiquantitative immunocytochemical techniques. In the second study animals were pretreated with the endothelin antagonist Bosentan (n = 6) or vehicle (n = 6) prior to spinal cord injury. Animals were euthanized at 24 h postinjury. Ten minutes prior to euthanasia animals were given horseradish peroxidase (HRP) intravenously. After perfusion fixation sections of cord were prepared for quantitative HRP histochemistry. After spinal cord injury there was enhanced staining for endothelin along the axis of the cord that correlated with the anatomical pattern of barrier breakdown to IgG. In those animals that were pretreated with Bosentan, there was a significant reduction in barrier breakdown along the axis of the injured cord as compared to those animals that received vehicle only. Taken together, this data implicate involvement of endothelin in the axial pattern of barrier breakdown after spinal cord injury.

Animals↗