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At least 19 recordsLinked to original sources
PubMed1980

Nonequivalence of automated and manual hematocrit and erythrocytic indices.

Manual and automated (Coulter) methods for determining hematocrit and mean corpuscular volume (MCV) were compared using blood specimens in which normal erythrocytes had been serially diluted in their own plasma. Thus, predicted linearity of hematocrit and predicted constancy of the erythrocytic indices were evaluated by these technics. Automated hematocrit was a rectilinear function of the erythrocyte count. Centrifuged hematocrit deviated systematically from the automated hematocrit; its correlation with the erythrocyte count was curvilinear. Automated erythrocytic indices were nearly constant throughout the range of dilutions of erythrocytes. The MCV, calculated from centrifuged hemtocrit and automated erythrocyte count, varied strikingly as a function of the latter. The range of MCV so observed was 62 to 105 fl for normal blood specimens, serially diluted, which, when undiluted, had MCV values in the range of 82 to 90 fl. Results of manual (centrifuged) hematocrit and erythrocytic indices appear to be inherently less reliable than those obtained by automated methods.

Centrifugation↗
PubMedDate not supplied

Erythrocyte indices in pregnancy: effect of intermittent iron supplementation.

BACKGROUND: Erythrocyte indices change in pregnancy, mainly due to physiological haemodilution and iron-deficient erythropoiesis. The present study was undertaken to determine the haematological indices during different periods of gestation in women receiving daily iron supplements and compare them with those in women receiving weekly iron supplements. METHODS: Pregnant women < 20 weeks of gestation attending the antenatal clinic at the All India Institute of Medical Sciences were randomized to receive either 100 mg elemental iron daily or 200 mg elemental iron weekly. The haemoglobin, haematocrit, mean corpuscular volume, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration were estimated at baseline, after 1 month, 3 months and at 34 weeks of gestation. RESULTS: Changes consistent with physiological haemodilution in mid-term pregnancy were noted and the values at 34 weeks of gestation were not significantly different between the two groups. CONCLUSION: The effects of intermittent iron supplementation on the erythrocyte indices in pregnancy are comparable with those observed with daily supplementation.

Adult↗
PubMed2005

Mature erythrocyte indices: new markers of iron availability.

This study was aimed at evaluating mature erythrocyte indices as new markers of iron status. Contrarily to those in the whole red blood cell (RBC) population, mature erythrocyte parameters are valid markers of iron status that remain independent of erythropoietic activity. When reticulocytosis is low, these parameters are similar to whole RBC parameters.

Adult↗
PubMed1978

Predictive values of erythrocyte indices for tests of iron, folic acid, and vitamin B12 deficiency.

The probabilities of low transferrin saturation, folic acid, or vitamin B12 levels in association with various erythrocyte indices was determined from the prevalences of these abnormalities and the distributions of the indices among 206 hospitalized and 1,000 ambulatory anemic patients. At mean corpuscular hemoglobin (MCH) greater than 30 pg, the probability of low transferrin saturation was 0.04 for hospitalized patients and 0.14 for ambulatory anemic patients. For MCH less than 27 pg, the corresponding probabilities were 0.52 and 0.67. The probabilities of low vitamin B12 or folic acid levels among hospitalized anemic patients were 0.0011 for mean corpuscular volume (MCV) less than 95 cu micron and 0.18 for MCV greater than or equal to 95 cu micron, indicating that measurements of these vitamins are of very limited value in most cases of anemia. These findings indicate that in some patients, the erythrocyte indices are sufficiently predictive for or against deficiency states to facilitate decisions regarding further diagnostic tests, as opposed to the increasing tendency to order such tests regardless of the indices.

Anemia, Hypochromic↗
PubMed2000

Hemoglobin and erythrocyte indices during normal pregnancy and postpartum in 206 women with and without iron supplementation.

BACKGROUND: The aim was to define reference values for hemoglobin, hematocrit and erythrocyte indices, i.e. erythrocyte count, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), in normal pregnancy and after a normal delivery in non-iron-supplemented and iron supplemented women. METHODS: Two hundred and six healthy Danish women included at 9-18 weeks of gestation were allocated to treatment with placebo tablets (n=107) or tablets containing 66 mg iron (n=99). Blood samples were obtained at inclusion, every fourth week during gestation, and 8 weeks postpartum. RESULTS: All hematologic indices were significantly lower in placebo-treated than in iron-treated women. In placebo-treated women, the 5th percentile for hemoglobin was 110 g/L in the 1st trimester; in the 2nd trimester it was 105 g/L in the first and the second, and 103 g/L in the last third; in the 3rd trimester, it was 102 g/L in the first, 100 g/L in the second, and 101 g/L in the last third; postpartum it was 113 g/L. In iron-treated women, the 5th percentile for hemoglobin was 111 g/L in the 1st trimester; in the 2nd trimester it was 109 g/L in the first, 106 g/L in the second, and 103 g/L in the last third; in the 3rd trimester, it was 105 g/L in the first and second, and 110 g/L in the last third; postpartum it was 123 g/L. CONCLUSIONS: Hematologic reference values should be derived from iron replete women. We suggest that the lowest critical hemoglobin value in iron-treated pregnant women should be 110 g/l (6.8 mmol/L) in the 1st trimester, and 105 g/L (6.5 mmol/L) in the 2nd and 3rd trimester.

Anemia↗
PubMed1990

The value of the erythrocyte indices as a screening procedure in predicting nutritional deficiencies.

The results of a large number of nutritional screen requests (n = 871) were compared with corresponding values of erythrocyte indices considered predictive of nutritional deficiencies to determine if such indices could be used in a prospective screening procedure to restrict the number of serum vitamin B12, folate, and ferritin assays. Low mean cell haemoglobins (MCH less than 27 pg) were found to be superior to low mean cell volumes (MCV less than 77 fl), in predicting low serum ferritin values. The occurrence of deficient ferritin values was 90% when the MCH was very low (MCH less than 23 pg). Vitamin B12 or folate deficiency could not be predicted from the MCV. A normal MCV was found in more than 55% of vitamin B12 deficient samples and some 30% of serum B12 deficients (less than 150 micrograms/l) showed no evidence of anaemia (Hb greater than 12 gm/dl) or macrocytosis (MCV less than 100 fl). It would not seem appropriate to use erythrocyte indices alone as a method of selecting samples for further investigation of folate or vitamin B12 status.

Adult↗
PubMed1993

[Usefulness of erythrocyte indices in the study of iron storage in infants].

For establishment correlation between erythrocyte indices and serum ferritin (SF), to identify infants at eighth months of age, with iron normal corporal stores, were studied 112 infants; 40 cases had severe deficient iron stores (SF < 12 ng/mL), 17 cases with "moderate" deficient iron stores (SF 12-20 ng/mL) and 55 infants with normal iron stores. The mean corpuscular hemoglobin (MCH) was altered in the 40.1%, the mean corpuscular volume (MCV) 29.5% and hemoglobin (Hb) 6.2%. In severe deficient iron stores, the MCH, with abnormal values had minor specificity (0.62), that MCV (0.88). With a SF < 20 ng/mL, specificity of the MCV was 0.92. Simultaneous alteration on MCH and MCV had similar specificity (0.92) and predictive positive values. With abnormal values of CMH + MCV or MCV alone, were established high probability for identify infants with normal iron stores.

Anemia, Hypochromic↗
PubMed1987

[Buffer systems, electrolytes, pH and erythrocyte indices in the blood of cows and calves in the perinatal period].

Determinations of pH, buffer systems, electrolyte levels and erythrocyte indices were carried out in the blood taken from the external cervical vein, arterial and venous vessels of the cow uterus and the umbilical cord of 9 healthy cows and their progeny, in the pre- and postnatal period. In this period the levels of the determined biochemical indices did not undergo any significant variations in the cows. The animals showed a normal acid-basic equilibrium. In contrast to the peripheral blood that of the uterus veins and arteries possessed higher levels of hydrogen carbonates, a higher partial CO2 pressure, but lower levels of electrolytes, hemoglobin and different oxygen exchange indices. The blood of calves in fetal life and at least till the 8th day after delivery showed the features of respiratory acidemia with relative hypercapnia. On feeding with colostrum, blood pH and buffer systems were normalized about the 10th day life of the new-born calf. A decrease in the number of erythrocytes, hemoglobin content and hematocrit value was observed in cows and calves after delivery. A simultaneous increase in the red blood cell volume and the level of bilirubin intensified hemolysis and aqueous shifts.

Animals↗
PubMed1989

Effect of varying levels of oyster shell on serum constituents and erythrocyte indices in growing chicken fed gossypol-containing Nigerian cottonseed cake.

The addition of calcium ions to iron-gossypol complex in phosphate solution has been reported to effect the removal of the soluble ferrous-gossypol complex from solution. These workers then postulated that the formation of insoluble ferrous-gossypol by calcium may explain the biological synergistic effect of calcium with iron in the inactivation of gossypol. Earlier studies by Skutches et al. indicated reduced haemoglobin, haematocrit and total serum protein in pigs fed 0.06% free gossypol diet. While other attempts at gossypol detoxification using divalent ions have been, mainly, in the form of calcium hydroxide and/or ferrous sulphate, this paper describes the dose-response relationships between dietary oyster shell (a much cheaper source of calcium than Ca(OH)2) and some serum constituents and erythrocyte indices in the chicken fed gossypol-containing cottonseed cake (CSC) diets.

Animals↗
PubMed1995

Erythrocyte indices as screening tests for the differentiation of microcytic anemias.

Algorithms for the differential diagnosis of anemias are commonly based on suspected incidences and simple laboratory parameters. Especially microcytic anemias are diagnosed using algorithms created in Mediterranean or Northern American regions. In a West German region we observe relatively high diagnostic uncertainty regarding common forms of anemias. As a hypothesis, this may be a result of inadequate algorithms not designed for regions with high incidences of anemias of chronic disease and low incidences of thalassemias. To further elucidate diagnostic problems we here report the frequencies of anemias in university hospital outpatients. Based on these data, the diagnostic values of different erythrocyte indices and of red cell distribution width in the differential diagnosis of anemias were calculated. 4525 patient files were reviewed retrospectively. 872 patients presented with anemia, 107 of which were hereditary forms and 765 of other forms. In hereditary anemias the frequency of thalassaemias (50 patients) and corpuscular hemolytic anemias (49 patients) was the same. Nearly half of the other anemias were covered by anemias of chronic disease and true iron deficiency anemias. Several indices intended to separate thalassemias from other microcytic anemias were tested for relevance. Sensitivity was between 0.75 and 0.85. Specificity was between 0.78 and 0.95. Red cell distribution width was not significantly different between thalassemias and iron deficiency. Only a red cell distribution width above 17.0 resulted in a specificity for iron deficiency of 0.91. Red cell distribution width is considered to be an unreliable screening test in a population with a low incidence of thalassemias. The high incidence of anemias of chronic disease in the region investigated should lead to more complex diagnostic procedures than offered by blood count values alone.

Anemia↗
PubMed1984

[Buffer systems, protein and electrolyte levels and erythrocyte indices in calves fed with beestings and milk substitutes].

By the method of Astrup were determined: pH of the blood, HCO3, act. pCO2, PO2, BB, BE, SO2, in a flame photometer: the concentration of Na+, K+, Ca++, Mg++, erythrocyte indices by the methods commonly used. Calves from cows fed with balanced feeds were born in a state of breathing acidosis at blood pH about 7.30 and at 26 mEq of bicarbonates concentration. Calves from cows fed with ensilages were born in a state of metabolic acidosis with blood pH 7.14 and HCO-3 act. - 14 mEq. Feeding with beestings alkalized the blood, increasing its pH from 0.06 to 0.11 and the concentration of bicarbonates which are the main regulators of acid-basic equilibrium in newborn calves. The concentration of sodium, potassium, calcium, chlorides and protein increased slightly despite a distinct hydration of the blood. Administration of a milk-substitute aggravated acidification of the organism and caused passing of physiological breathing acidosis to the state of metabolic acidosis. On using the milk-substitute, hydration of the blood occurred and the level of the other parameters determined decreased. Milk-substitutes should not be given calves in their early period of life.

Animal Feed↗
PubMedDate not supplied

Erythrocyte indices for discriminating thalassaemic and non-thalassaemic microcytosis in Indians.

BACKGROUND: Microcytosis is a common red cell change seen in anaemias of varied aetiology. These include iron deficiency, thalassaemia, chronic disease and sideroblastic anaemias. The microcytosis of heterozygous beta-thalassaemia needs to be distinguished from non-thalassaemic microcytosis for its role in thalassaemia control. Red cell indices derived from automated red cell analysers have been used to discriminate between microcytic patients with a high probability of thalassaemia minor from those with a low probability. There is a controversy on the choice of red cell indices to be used and the cut-off values for this distinction, because the prevalence of iron deficiency as a cause of non-thalassaemic microcytosis is variable. Since no Indian study using receiver operator characteristic (ROC) curves was available to determine the above, we conducted this study. METHODS: Red cell indices (mean corpuscular volume, total red blood cell count, red cell distribution width, linear discriminant function), serum iron, total iron binding capacity and haemoglobin A2 were estimated in 640 adults with microcytosis (mean corpuscular volume 80 fl). The ROC curves were plotted in all. RESULTS: Total red blood cell count was observed to be the most efficient single test followed by linear discriminant function and Bessman index. Mean corpuscular volume had the least efficacy. The cut-off values obtained for the Indian population were mean corpuscular volume < or = 76 fl, total red blood cell count > or = 4.9 x 10(12)/L and red cell distribution width > or = 18% and a positive linear discriminant function. These were different from those observed in the West, possibly because of the high prevalence of iron deficiency in India. CONCLUSION: In countries with a high prevalence of iron deficiency, cut-off values for red cell indices should be recalculated using ROC curves.

Adult↗
PubMed1983

[New constellation of erythrocyte indices characterizing iron metabolism].

Via the determination of hemoglobin, erythrocytes, hematocrit and erythrocyte iron, a constellation is proposed for the assessment of iron metabolism in organism. The percentages of saturation of hemoglobin by iron, the absolute iron content of erythrocytes the erythrocyte iron per litre blood, erythrocyte iron in litre erythrocytes were calculated on the base af the data of the above mentioned indices. The index for the evaluation of erythropoiesis activity was calculated on the base of the determination of hematocrit, erythrocytes and erythrocyte iron, and via the determination of hemoglobin and erythrocyte iron - the iron reserves in organism were calculated. The constellation, making use of minimum quantity peripheral blood enables the characteristic of iron metabolism as far as 70 per cent of the iron in organism is conjugated with hemoglobin, erythrocytes, respectively.

Child, Preschool↗