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At least 19 recordsLinked to original sources
PubMed2003

The control of nitrilotriacetic acid in edetic acid and its salts by liquid chromatography.

Two liquid chromatographic methods have been developed and validated for the determination of nitrilotriacetic acid (NTA) in edetic acid (EDTA) and its salts. In one method NTA and EDTA are separated on a polymer column without pretreatment, and are detected amperometrically using a glassy-carbon electrode. In the other method NTA and EDTA are complexed with ferric ions and the complexes separated on a porous graphite carbon stationary phase with ultraviolet detection at 215 nm. Both methods were sufficiently selected and sensitive to allow the control of NTA (0.1% m/m) in sample of EDTA and its salts.

Chromatography, Liquid↗
PubMed1988

Use of theophylline in the investigation of pseudothrombocytopenia induced by edetic acid (EDTA-2K).

In automated cell counting of edetic acid (EDTA-2K) anticoagulated blood, thrombocytopenia is occasionally seen which bears no relation to any underlying disease. In this study a heparin and soluble theophylline mixture was used to measure accurately platelet numbers in patients with such pseudothrombocytopenia. In four normal volunteers, a theophylline concentration of more than 7 mg/ml produced no significant difference in platelet numbers between theophylline and heparin and EDTA-2K anticoagulated bloods. When blood treated with EDTA-2K was used in seven patients with pseudothrombocytopenia, falsely low platelet counts were observed in three patients immediately after sampling; in blood treated with theophylline, white cell and platelet counts remained unchanged for up to six hours after sampling. Microscopical examination of the EDTA-2K anticoagulated blood showed massive platelet clumping, but no aggregates were seen in theophylline anticoagulated blood. It is concluded that theophylline can be useful in the investigation of pseudothrombocytopenia when an automated cell counter is used.

Adult↗
PubMed1982

Clinical limitations of the estimation of glomerular filtration rate from height/plasma creatinine ratio: a comparison with simultaneous 51Cr edetic acid slope clearance.

A retrospective comparison of single determinations of glomerular filtration rate measured by 51chromium-edetic acid slope clearance (CEDTA) and height/plasma creatinine ratio (Ht/PC) was undertaken in 199 children aged between 3 and 16 years. Analysis of the data indicated that only if Ht/PC less than or equal to 1.2 cm/mumol per 1 was the relationship between Ht/PC and CEDTA linear. Over this range where renal function is significantly impaired the confidence limits for individual prediction of glomerular filtration rate were so wide that a definitive measurement of renal function would be necessary in clinical practice. Where Ht/PC greater than or equal to 1.2 the relationship was non-linear and the predictive confidence limits very wide. To apply the technique as a screening test for normal renal function (CEDTA greater than or equal to 80 ml/min per 1.73 m2) the Ht/PC would need to exceed 2.16. In our study this would have detected 57 out of 131 patients who had normal glomerular filtration rates and erroneously included 2 out of 68 with subnormal renal function.

Adolescent↗
PubMed1994

Dissolution of calcified gallstones. Part II. Evaluation of edetic acid preparations for dissolution of residue after in vitro methyl tert-butyl ether treatment.

RATIONALE AND OBJECTIVES: The authors assessed the potential of edetic acid (EDTA) preparations to dissolve the residue of calcified gallstones partially treated with methyl tert-butyl ether (MTBE). METHODS: Nineteen triplets (57 gallstones) were submitted to dissolution in EDTA, urea-EDTA, and an MTBE control for 48 hours after initial partial dissolution in MTBE for 24 hours. Results were compared with findings at specimen computed tomography and crystallographic analysis. All data were corrected for differences in stone size. RESULTS: In all three treatment groups (EDTA, urea-EDTA, MTBE), almost identical dissolution outcomes were observed within each triplet. Most triplets that dissolved displayed a laminated or a core-calcification pattern and consisted primarily of cholesterol. Specimens that dissolved poorly in all three groups displayed dense calcifications or thick calcified rims and were classified as pigment stones. CONCLUSION: Because no statistically significant differences in dissolution were found among the EDTA, urea-EDTA, and MTBE treatments, we conclude that EDTA preparations are not superior to the continued use of MTBE for dissolution of residue after initial MTBE treatment.

Chelating Agents↗
PubMed1990

Apparent failure of edetic acid chelation therapy for the treatment of coronary atherosclerosis.

Patients diagnosed with incurable or fatal diseases may seek alternatives to standard medical therapy and spend significant amounts of money for these therapies. One alternative medical therapy, chelation therapy with edetic acid (EDTA), has gained considerable popularity for the alleged treatment of atherosclerotic vascular disease; however, its efficacy for this indication remains unproven and its use is controversial. We present a case in which chelation therapy was unsuccessful in treating coronary atherosclerosis and review reports that substantiate a lack of efficacy using chelation therapy in the treatment of coronary atherosclerosis. Treatment of atherosclerotic-related diseases using chelation therapy should be discouraged by health professionals. Patients should be counseled regarding the risk of improper diagnosis and treatment of their disease.

Aged↗
PubMed1994

Effects of estrogen on response to edetic acid infusion in postmenopausal osteoporotic women.

We and others have hypothesized that estrogen helps preserve bone mass by affecting the PTH/vitamin D regulation of skeletal metabolism. To evaluate this theory, we tested the effect of estrogen administration on parathyroid sensitivity to hypocalcemic challenge. Subjects were postmenopausal osteoporotic women recruited from a tertiary care clinic (9 untreated and 12 receiving hormone replacement therapy at the time of the investigation). After baseline serum and urine testing, edetic acid (50 mg/kg) was infused over a 2-h period. Serum and urine samples were obtained over 5 h and 24 h after beginning the infusion. Serum ionized calcium dropped equally in both groups of women. There were overall group differences in PTH-(1-84) secretion (P < 0.02), with a greater peak (P < 0.04) and a longer period of elevation (P < 0.01) in the untreated than in the hormone-treated osteoporotic women. Serum 1,25-dihydroxyvitamin D [1,25-(OH)2D] and phosphorus as well as urinary phosphate and cAMP responded similarly in the two groups of women. Estrogenized osteoporotic women demonstrate a smaller PTH increment to hypocalcemia, indicating that the parathyroid has reduced sensitivity under the influence of estrogen. Despite the smaller PTH increase in estrogenized individuals, renal responses to PTH were the same as those in untreated osteoporotic women, implying an estrogen-mediated increase in the sensitivity of the kidney to PTH.

Administration, Oral↗
PubMed1993

Granulocyte aggregation is edetic acid and temperature dependent.

Nineteen cases of leukocyte agglutination were observed in the last 6 years, while performing routine blood cell counts with an autoanalyzer (Technicon H6000). The phenomenon occurred only in edetic acid-anticoagulated samples and only at room temperature. Leukocyte aggregation could be reproduced by incubating patient serum samples or edetic acid-plasma with whole blood from ABO-compatible healthy control subjects. When patient serum samples or plasma samples were first preincubated with anti-IgM serum and then mixed with normal blood, leuko-agglutinates were not observed, suggesting that a plasma factor, probably an IgM, was responsible for the phenomenon. Nonetheless, IgM presence could not be correlated with any particular disease or the use of specific drugs.

Adult↗