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At least 19 recordsLinked to original sources
PubMedDate not supplied

Management of trachomatous cicatricial entropion of the upper eye lid: our modified technique.

BACKGROUND: Management of trachomatous cicatricial entropion of the upper eye lid presents a difficult problem. Many surgical approaches have been developed to address it. We report the functional and cosmetic results of our modified surgical technique we have developed in the management of trachomatous cicatricial entropion of the upper eye lid. METHODS: 45 lids of 43 patients having trachomatous cicatricial entropion of upper eye lids were operated by our modified surgical technique in which we combine bilamellar tarsal margin rotation procedure with blepharoplasty. The technique and results were evaluated in a follow up period of up to 40 months. RESULTS: In all 45 upper eye lids, the normal eyelashes rotated away from the surface of the eye and were no longer in contact of the eye ball in all position of gaze. All eyes had adequate lid closure and regular lid margin. No eye had any overhanging baggy fold of skin at operation site. Three eyes had conjuctival granuloma which was excised under local anaesthesia Three eyes needed Diode laser ablation to treat isolated cilia posterior to normal lash line. Three eyes had mild over correction which regressed without any surgical intervention. One lid had segmental necrosis of distal part of eye lid which recovered spontaneously in following days. CONCLUSION: Our modified technique of combining bilamellar tarsal rotation procedure (BTR) with blepharoplasty appears to be an effective surgical technique in the management of the trachomatous cicatricial entropion of the upper eye lid. It achieves successful anatomical correction along with more acceptable cosmetic appearance.

Aged↗
PubMed1996

Retinal melatonin is not involved in corneal mitotic rhythms in the Japanese quail: effects of formoguanamine hydrochloride and eye-lid suture.

Relation between retinal melatonin and corneal mitotic rhythms in the Japanese quail was investigated in experiments manipulating the ocular physiology by treatments with formoguanamine hydrochloride (FG) and eye-lid suture. In experiment 1, we investigated the effects of FG, which is known to induce photoreceptor degeneration, on retinal melatonin and corneal mitotic rhythms. FG-treatment completely abolished the retinal melatonin rhythms in both LD 12:12 and constant darkness (DD), but the corneal mitotic rhythm was maintained with high mitotic rate in darkness under a LD cycle and subjective night under DD. The result suggests that 1) the photoreceptor cells in the retina are the site for melatonin production and/or for the oscillator which drives the circadian rhythm in retinal melatonin, and 2) melatonin is not involved in generation of the corneal mitotic rhythm. In experiment 2, we investigated the effects of eye-lid suture, which is known to induce eye enlargement and bulgy cornea, on the retinal melatonin and corneal mitotic rhythms. Eye-lid suture abolished the corneal mitotic rhythm in both LD and DD, with a high mitotic rate being maintained throughout 24 hr. But retinal melatonin maintained its rhythm with high levels in darkness under a LD cycle and in subjective night under DD. The result suggests that 1) bulgy cornea in the sutured eye was induced by the increase in mitotic rate in the light period, and 2) disappearance of the corneal mitotic rhythm does not have a relation to retinal melatonin. These results suggest that retinal melatonin is not involved in generation of the corneal mitotic rhythm and that there are two circadian clock systems in the eye.

Animals↗
PubMed2005

[A 65-year-old man with rigid-bradykinetic parkinsonism, vertical gaze palsy, difficulty of eye-lid opening, and marked pseudo-bulbar palsy].

We report a 65-year-old man with rigid-bradykinetic parkinsonism, vertical gaze palsy, difficulty in eye-lid opening, and marked pseudo-bulbar palsy. He felt difficulty of it, hand movement at 59 years old. When he was 60 years old, monotonous speech and slowness of movement appeared. He visited a neurologist who noted vertical gaze palsy, neck rigidity, and bradykinesia. He was diagnosed as progressive supranuclear palsy (PSP) and given 300 mg L-Dopa/Benserazide by the neurologist. This medication improved his rigidity and bradykinesia. At 62 years of the age, his eye-lids closed involuntary and it was difficult to open. In addition, he began to complain of wearing-off, autonomic symptoms, and dysphagia. Anti-parkinsonian drugs were increased, but his bradykinesia progressed. At 64 years of the age, he was admitted to the Neurology Service of Juntendo Hospital. On admission, he was alert and not demented. No aphasia, apraxia, or agnosia was noted. In the cranial nerves, upward and downward gaze were markedly restricted. His face was hypomimic and seborrhoic. It was difficult to swallow liquid or solid for him. No weakness was noted, but he walked in small steps with freezing and falling tendency to backward. Rigidity was noted on his extremities and stronger on his left side than right. Tremor was absent. Bradykinesia of his body and extremities was marked. No cerebellar ataxia was noted. Deep tendon reflexes were within normal range. Planter response was flexor bilaterally. Myerson's sign was noted. Sensory and autonomic function were normal. He was treated with L-Dopa, Pergolide, and Bromocriptine. However, these medications improved his bradykinesia and gait disturbance only slightly, dysphagia became progressively worse. He developed aspiration pneumonia when he was 65 years old and admitted to Juntendo Hospital. A large amount of sputum was aspirated from his trachea. Two days after from admission, he was found dead on his bed. He was discussed in a neurological CPC and the chief discussant arrived at a conclusion that the patient had progressive supranuclear palsy (PSP). Other differential diagnoses included Parkinson's disease, pallido-nigroluysian atrophy (PNLA), multiple system atrophy (MSA), and corticobasal degeneration(CBD). Many participants considered that PSP or PNLA was most likely. Post-mortem exmination revealed marked nigral neuronal loss and gliosis. The globus pallidus and the luysian body changed mildly. However, the frontal cortex was relatively spared, there were many ballooned neurons in the cortical layer. Other parts were spared. With sliver (Bodian and Gallyas-Braak) and anti-phsphorylated tau stain, abundant astrocytic plaques, neurofibrillary tangles, and argyrophilic threads on the frontal cortex, striatum, and substantia nigra were seen. There was no tufted astrocyte which was hallmark of diagnosis of PSP. In addition, several Lewy bodies were seen in the brainstem. Because astrocyte plaque was considered specific for pathology of CBD, the pathologist revealed that the pathological diagnosis of this patient was CBD. Nevertheless, discussion was focused on the relatively mild degeneration of the frontal cortex for CBD.

Aged↗
PubMed1988

Lid-eye coordination during vertical gaze changes in man and monkey.

1. To investigate the coordination between the upper lid and the eye during vertical gaze changes, the movements of the lid and the eye were measured by the electromagnetic search-coil technique in three humans and two monkeys. 2. In both man and monkey, there was a close correspondence between the metrics of the lid movement and those of the concomitant eye movement during vertical fixation, smooth pursuit, and saccades. 3. During steady fixation, the eye and lid assumed essentially equal average positions; however, in man the lid would often undergo small idiosyncratic movements of up to 5 degrees when the eye was completely stationary. 4. During sinusoidal smooth pursuit between 0.2 and 1.0 Hz, the gain and phase shift of eye and lid movements were remarkably similar. The smaller gain and larger phase lag for downward smooth pursuit eye movements was mirrored in a similar reduced gain and increased phase lag for downward lid movements. 5. The time course of vertical lid movements associated with saccades was generally a faithful replica of the time course of the concomitant saccade; the similarity was especially impressive when the details of the velocity profiles were compared. Consequently, lid movements associated with vertical eye saccades are called lid saccades. 6. On average, lid saccades start some 5 ms later than the concomitant eye saccades but reach peak velocity at about the same time as the eye saccade. Concurrent lid and eye saccades in the downward direction have similar amplitudes and velocities. Lid saccades in the upward direction are often smaller and slower than the concomitant eye saccades. The relation of peak velocity versus amplitude and of duration versus amplitude are similar for lid and eye saccades. 7. To investigate the neural signal responsible for lid saccades, isometric tension and EMG activity were recorded from the lids of the two authors. 8. The isometric tensions during upward lid saccades exceeded the tensions required to hold the lid in its final position.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMed1994

Normalisation of asymmetric astigmatism after intralesional steroid injection for upper eye lid hemangioma in childhood.

Infantile hemangiomas affect about 5% (3%-8%) of the population, showing a predilection for the face. After a phase of rapid enlargement between the 3rd and the 9th month of life, 70% regress by the age of six after a period of stability. 43%-60% of the children with eye lid hemangiomas develop strabismic, anisometropic, or deprivation amblyopia. Previous studies found the majority of cases resulting from anisometropia (especially asymmetric astigmatism) rather than strabism or occlusion of the visual axis. Several methods of treatment--surgical excision, irradiation, sclerosing agents, systemic steroids, ligation, cryotherapy--have been used but all with a risk of local or systemic complications. Local injections of steroids are a simple method of therapy with a high rate of resolution of hemangiomas, but still with a high degree of bad visual output because of persistent astigmatism. In four children with asymmetric astigmatism (axis of astigmatism towards the hemangioma) in which the injection was given at the beginning of the phase of enlargement, amblyopia could be avoided by preventing corneal steepening from becoming permanent.

Anti-Inflammatory Agents↗
PubMed2004

[Detection of a mutant HSV-1 in a patient presenting efflorescence on an eye lid].

A 9-month-old boy with impetigious blepharitis of the right eye was admitted to the Department of children and adolescents of the Kralovske Vinohrady University Hospital. NA isolated from lesion fluid was screened using real-time PCR based HSV 1/2 detection kit (Roche). Differentiation between HSV types 1 and 2 in this assay is based on variation of double-stranded DNA melting temperature (Tm), being 54 degrees C +/- 2,5 degrees C for HSV-1 and 66,5 degrees C +/- 2,5 degrees C for HSV-2. Since the amplified NA from the sample showed an atypical Tm of 59 degrees C, nested PCR was used for futher analysis: the presence of HSV-1 NA was confirmed by the latter. In spite of the atypical Tm value, the eyelid infection was responsive to acyclovir and resolved after intravenous Herpesin given for 5 days.

Eyelids↗
PubMed2001

[Expression significance of P21WAF1/CIP1 protein in eye-lid primary malignant tumor].

PURPOSE: To study the expression of P21waf1/cip1 protein in eye-lip primary malignant tumor (E-LPMT). METHODS: Immunohistochemical streptavidin biotin peroxidase complex(SP) method was used to stain section of E-LPMT. RESULTS: In 61 cases of E-LPMT, positive expression of P21waf1/cip1 protein was found locating in the nuclei. In Cell carcinoma, Squamous and Adenocarcinomas, the positive rate of P21waf1/cip1 protein expression were 36.0%, 27.8% and 22.2% respectively. The positive rate of P21waf1/cip1 protein expression in well-differentiated Cell carcinomas or Adenocarcinomas was higher than in poor-differentiated ones (P < 0.01). CONCLUSION: P21waf1/cip1 protein expresses in various type of E-IPMT and its positive expression in Cell carainomas and Adenocarcinomas are related to their different degrees.

Adenocarcinoma↗
PubMed1980

Cysticercus cellulosae in the lacrimal gland, orbit, and eye lid.

Six cases of adnexal cysticercosis, (1 in the lacrimal gland, 3 orbital, and 2 palpebral) have been reported. In the lacrimal gland it presented as a painless, translucent cyst which closely simulated a simple dacryops. In the orbit, two of the cases presented as an acute abscess in the upper and inner quadrant. However, one of them initially presented and existed as a case of simple ptosis for a period of 8 months. The third orbital case appeared as a painless cyst in the upper and outer quadrant. In the lid the larva presented as a subcutaneous nodule in one case and in the other it was lodged in the orbicularis oculi muscle. The cyst was surgically removed in all cases and the diagnosis was confirmed by histopathological examination. Lodgement of cysticercus cyst in the lacrimal gland and in the orbicularis oculi muscle is reported for the first time.

Adolescent↗