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Results for “Dicrocoeliasis”

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At least 19 recordsLinked to original sources
PubMed2003

Treatment of Egyptian dicrocoeliasis in man and animals with Mirazid.

Two human cases with dicrocoeliasis dendriticum were successfully treated one with Praziquantel (25mg/kg 3 times daily after meals, for four successive days) and second with Mirazid (2 capsules of 300 mg. each, daily an hour before breakfast, for six successive days) as indicated clinically and parasitologically. On the other hand, one imported sheep and two locally bred goats naturally infected with D. dendriticum were successfully treated with Oleo-resin solution (dose of 6 ml of 10 gm% equal to 2 Mirazid capsules before breakfast) per os once daily for four successive days. The animals were slaughtered on 5th day. Mirazid (capsule or Oleo-resin solution) was effective against dicrocoeliasis in man and animal respectively.

Animals↗
PubMed2004

Myrrh (Commiphora molmol) in treatment of human and sheep dicrocoeliasis dendriticum in Saudi Arabia.

Dicrocoeliasis dendriticum is now imposing itself as an animal and zoonotic helminthic disease in many Arabian countries. Myrrh extract of Commiphora molmol (Mirazid) successfully and safely treated clinically and parasitologically proven 18 human dicrocoeliasis dendriticum patients. The dose was 2 capsules (300 mg each) given on an empty stomach an hour before the breakfast for six successive days. Cure (100%) was achieved clinically and by stool analysis for two months follow up. Besides, fifteen sheep naturally infected with Dicrocoelium dendriticum as proven parasitologically were successfully and safely treated with 2 capsules (300 mg each) on an empty stomach an hour before breakfast for four successive days. Cure (100%) was successfully achieved by stool analysis for seven days and macroscopically for detection of any adult worm after being slaughtered. The total dose required to treat infected sheep (2400 mg) was less than that required for human treatment (3600 mg).

Administration, Oral↗
PubMed2003

A preliminary study on dicrocoeliasis in Egypt, with a general review.

Dicrocoelium dendriticum (D. dendriticum) is a lancet-shape liver fluke that affects sheep and mammals including man. Human and animal infections have been world widely reported particularly in some of the Eastern Mediterranean sheep raising countries. Infection is acquired by eating the second intermediate host (17 species of ants) with raw fruits, vegetables, herbs or even with the drinking water. As for the first intermediate host, there is about 54 different species of land snails. In spite of the fact that both the first and second intermediate hosts of D. dendriticum are available in Egypt, data about human and animal dicrocoeliasis is lacking. This investigation is a preliminary study to report on the presence of D. dendriticum (in sheep, goats and man in North Sinai Governorate) in Egypt.

Adolescent↗
PubMed1981

Experimental dicrocoeliasis: the humoral immune response of golden hamsters and rabbits to primary infection with Dicrocoelium dendriticum.

The results presented deal with the humoral immune response of golden hamsters to primary experimental infection with D. dendriticum. The development of serum antibodies has been comparatively investigated with three hamster groups (n = 43) harbouring different burdens of adult flukes. The mean numbers of parasites were 11, 30, or 130 per animal. Serum antibody response was studied during an observation period of at least 331 and up to 496 days postinfection. For antibody detection the sensitivities of precipitation test (PTs) (double diffusion test, immuno- and counterimmunoelectrophoresis), of the indirect haemagglutination test (IHAT), the complement fixation test (CFT), and the enzyme linked immuno sorbent assay (ELISA) were compared using aqueous crude fluke antigen and crude egg antigen. CFT and ELISA were most sensitive for the early detection of initial response. Thereafter all the tests employed revealed increasing antibody titres, which in general remained at constant levels and persisted until the end of the observation period with the exception of CF-antibodies. In general fluke antigen was found to be more sensitive than egg antigen. However, in CFT this antigen occasionally has been associated with unspecific inhibition of haemolysis. Comparison of the results shows that ELISA using crude fluke antigen gave the most realistic picture of the actual fluke burden. Also preliminary results on the precipitin response of rabbits (n = 3) after primary experimental exposure to different numbers of metacercariae (500, 1,000, and 3,000 per animal respectively) are reported. Employing the above mentioned PTs a persisting antibody response could be demonstrated only after exposure to at least 3,000 infective larvae. The initial response was found on day 63, the observation period was 550 days.

Animals↗
PubMed2005

Field and experimental studies on Dicrocoelium dendriticum and dicrocoeliasis in northern Spain.

The transmission, control and the relationship between Dicrocoelium dendriticum and its definitive (sheep and cattle) and intermediate (molluscs and ants) hosts under natural and experimental conditions are described. Eleven species of molluscs and four of ants were found infected with larval D. dendriticum in León province, north-west Spain. Infected ants were observed between April and November and in tetania at 7.5-26.9 degrees C. The highest shedding of eggs by sheep and cattle was detected in winter. Two treatments applied in November and January were the most effective. In experimentally infected molluscs, the parasite was not visible under the stereomicroscope, at least until 50 days post-infection (p.i.). The prepatent period in experimentally infected lambs was 49-79 days p.i. The number of eggs per gram increased with the days p.i. and the parasite burden. The aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transpeptidase, leukocyte and neutrophil values of infected lambs increased, but those of lymphocytes decreased. Using the enzyme-linked immunosorbert assay technique, the IgG antibody response to excretory-secretory and somatic antigens of D. dendriticum was positive from day 30 p.i., although the maximum antibody levels were observed on day 60 p.i. The number of worms per lamb ranged between 30 and 2063. Cholangitis and cholangiectasia of the septal bile and hepatic ducts were observed. The best enzymatic systems for adult and larval D. dendriticum characterization were lactate dehydrogenase, glucose phosphate isomerase and phosphoglucomutase. Genetic variability of adult D. dendriticum was high using the random amplified polymorphic DNA technique.

Animals↗
PubMed1999

Natural dicrocoeliasis in imported sheep, Jeddah, Saudi Arabia.

Dicrocoelium dendriticum is a common liver fluke of sheep and other herbivorous animals. Examination of imported sheep showed 40% in Somalian sheep, 26% in Turkish and 2% in native breed sheep. The results were discussed with stress on epidemiology.

Animals↗
PubMed1990

Human dicrocoeliasis. Report on 208 cases from Saudi Arabia.

In 3 years, Dicrocoelium dendriticum ova were detected in 208 patients at the Armed Forces Hospital, Riyadh, Saudi Arabia during 1984-1986. At least 7 of these patients had a true infection and at least 34 patients had spurious infection as they gave a history of eating raw liver. 23% of the 208 patients were under 14 years of age. The peak incidence was between October and November in each of the 3 years. 134 of these patients were symptomatic. 16 patients had disturbed liver functions and 13 had eosinophilia. 10 patients had gall bladder or biliary tree disease and in at least 2 of which it was due to D. dendriticum. Malabsorption occurred in one patient. Praziquantel was used in 9 patients and was successful in treating 4 of these patients.

Adolescent↗
PubMed1989

[A rare case of human autochthonous dicrocoeliasis in Czechoslovakia].

The first case of not imported dicroceliasis in Czechoslovakia is reported in an eleven-year-old boy. The patient suffered from gastrointestinal complaints for about half a year. Diarrhea frequently alternated with constipation, the abdominal pain was mainly in the region of the pancreas. With the exception of eosinophilia (16%), all other laboratory findings (blood count, ELFO, urinalysis) were within normal values. Eggs of Dicrocoelium dendriticum were repeatedly found in stool specimens. The patient was successfully treated with Bithin (4,6-dichlorpentol). Examination of the other members of the family proved negative. At present the patient is without complaints, stool examinations for parasites were repeatedly negative. Contact with sheep or consumption of contaminated liver was not demonstrated. The parasitic infestation may have occurred via an intermediate host, as the patient was keen on collecting different animals, particularly snails.

Child↗