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At least 19 recordsLinked to original sources
PubMed1977

Studies on cold insoluble globulin in dermatological patients. II. Its immunochemical quantitation in citrated plasma in a group of unselected dermatological inpatients.

Cold insoluble globulin (CIG) is the main non-clottable protein of heparin precipitable fraction from dermatological patients. CIG is a glycoprotein with a molecular weight of about 440 000. It is found on cell membranes on fibroblasts and is a normal protein of human plasma and serum. Levels of CIG in citrated plasma are sex- and age-dependent, but the origin and its physiological significance is unknown. In plasma of 294 dermatological patients, levels of CIG were elevated in eczema contactum allergicum (males and females 30-49 years), psoriatic arthritis (females 50 years and above) and were depressed in dermatitis herpetiformis (males 30-49 years).

Adult↗
PubMed1979

DermRx. An experiment in computerizing information on dermatologic therapy.

The Task Force for Creating a Biomedical Communications System for Dermatology was commissioned by the American Academy of Dermatology to develop an experimental segment of a computerized data bank on dermatologic therapy. The Task Force has completed such a "first generation" system and has named it DermRx. Its data bank carries the following information on each entry: the name of the disease; topical, systemic, physical, and other kinds of treatment; caveats; references to the literature; and the date and reviewer(s). The DermLit and DermRx programs are two components of a projected broader concept of an eventual comprehensive Biomedical Communications System for Dermatology. Such a system is envisaged as a means of making available to dermatologists diverse data relevant to practice, teaching, research, and business aspects of the specialty. At the moment, access to the stored information on dermatologic literature and therapy is by telephone call to, or by correspondence with, the central computer facility at Northwestern University. Eventually it is projected to be accessible by dedicated microcomputers housed in the physician's office. This preliminary report on DermRx is presented to review the progress of the project to date and to elicit comment upon its structure and value.

Dermatology↗
PubMed1976

[Dermatological complications after renal transplantation (author's transl)].

58 renal transplant patients were submitted to dermatological check-up investigations at regular intervals over a mean period of 26.2 months after surgery. 98% of the case material showed dermatological complications. In an analysis of the findings in 55 patients with infectious complications, viral infections occurred in 40, bacterial in 30 and mycotic infections in 20 patients. Dermatological manifestations of non-dermatological complications were mainly due to immunosuppressive therapy. The data stress the necessity of optimum cooperation between dermatologists and the attendant physician in the case of renal transplant patients.

Adolescent↗
PubMed1979

The challenge of biophysics to dynamic dermatology.

Dermatologic biophysics has much to offer both clinical and investigative dermatology. For the clinician, the radiation biophysicist can provide accurate measurements of ionizing and nonionizing outputs, including those for PUVA, and critical evaluation of radiation safety measures. In optics, there is a need for accurate measurements of skin color and examination of the skin at moderate magnification. The biophysicist, with the biomedical engineer, can improve all the physical modality instrumentation used in practice. In investigative dermatology, there is the cellular biophysics of radiation. Doppler techniques for skin circulation, spectroscopy of living cells, and many other applications are suggested for current and future studies.

Biophysical Phenomena↗
PubMed2026

The emerging applications of JAK inhibitors in dermatology - a systematic review.

BACKGROUND: Janus kinase (JAK) inhibitors are established treatments for selected dermatologic conditions, but their off-label use has expanded across refractory skin diseases. METHODS: We systematically searched MEDLINE, Embase, and Web of Science from inception to October 1, 2025, for studies reporting off-label JAK inhibitor use in dermatologic disorders beyond approved or late-phase trial indications. RESULTS: Of 9,182 records screened, 277 studies met the inclusion criteria, comprising 210 case reports, 55 case series, and 12 retrospective studies involving 764 patients. Owing to substantial clinical heterogeneity, findings were narratively synthesized using a structured disease-family framework. Off-label use most commonly involved lichenoid, neutrophilic, and granulomatous dermatoses. Overall, 725/764 (94.88%) patients experienced clinical benefit, including complete or near-complete response in 209/764 (27.35%) and significant or partial improvement in 516/764 (67.53%). Thirty-five patients (4.58%) showed no clinical change, and four (0.52%) experienced disease worsening. A total of 154 adverse events were reported, most commonly with tofacitinib; most were mild to moderate, although six were serious and 25 resulted in treatment discontinuation. CONCLUSION: JAK inhibitors demonstrate promising therapeutic potential across a broad spectrum of refractory dermatological diseases. The predominance of uncontrolled case-based evidence, heterogeneous dosing, and frequent combination therapy limits attribution of efficacy and safety to JAK inhibitor monotherapy. Prospective controlled studies are needed to better define their therapeutic role.

Humans↗
PubMed1979

Malpractice--in dermatology.

Among twenty-three types of physicians, dermatologists rate sixth lowest in malpractice risk. With dermatology, the risk of a suit is general; no one doctor or type of dermatologic practice has been shown to bear unusual risk--everyone is susceptible. However, dermatologist who give x-ray therapy or limit their work to cosmetic procedures rate higher. Patients sue because of facial burns or scars, negligent diagnosis, drug reaction, falls in the office, wart removal, and treatment that exceeds the patient's desire at the moment. Care must be exercised in the use of problem drugs such as antineoplastic agents, corticosteroids, oral contraceptives, sulfones, vitamin A acid, liquid nitrogen, cantharidin, podophyllin, and fluorescent dyes. Dermatologists are urged to obtain consultation for the benefit of patient and doctor, to maintain good relations with fellow physicians, and to avoid inappropriate criticism of other physicians. Lengthy lists of "do's" and "don'ts" in patient care are included, and some possible changes in the malpractice situation are listed.

California↗
PubMed1979

[Trends in some treatment-criteria of patients of a dermatological children-ward (author's transl)].

In comparative studies on some treatment-criteria of patients of a dermatological children-ward between 1967, 1969, 1971, 1973, 1975 and 1977 we found a tendency to increased out-patient-treatment, a reduction in period of clinical sojourn and a significant increase in patients drug consumption. Most important reasons of this development are the following: Temporary decrease of birth rate in GDR; increased capacity of out-patient-treatment in the Leipzig-area; application of more effective drugs; improvements in management of clinical treatment. About 50% of treated in-patients are 0 to 3 years old. The great importance of a qualified dermatological treatment for success of clinical sojourn on a children-ward is underlined.

Adolescent↗
PubMed1979

The cost of treatment of dermatological disorders in hospital versus health centre.

Well-run outpatient services and reasonable charges to patients for drugs have led to reduced hospitalisation of dermatological patients and hence a reduction in the total cost of nursing and treating such patients in comparison with previous years, when there was greater emphasis on hospital treatment. There is at present no waiting list for dermatological beds at the National Hospital.

Ambulatory Care Facilities↗
PubMed1977

[Ichthyosis hystrix gravior typus Rheydt: an otologic-dermatologic syndrome (author's transl)].

A case of congenital ichthyosis hystrix gravior combined with non-progressive inner ear hearing loss bordering on deafness is reported. None of the syndromes of keratinization disturbances combined with hearing loss of the inner ear known up to now is comparable. The patient was examined by the dermatologic and otorhino-laryngologic clinics. The findings were presented at the "Südwestdeutschen Dermatologen-Kongress in Heidelberg 1976". Particular otologic findings were a non-progressive inner ear hearing loss bordering on deafness, a fungus-covered cell detritus in the cartilaginous part of the external ear canal, and hyperkeratosis of the auricula. Specific dermatologic findings were skin hyperkeratoses most prominent on face and extremities. In it's ultrastructure, this type is basically different from all other types of inherited ichthyoses that have been studied by electron microscopy. Combined with a lack of normal tonofilaments, an unusual synthesis of large amounts of mucous granules is present under the large spines that is not normally found in healthy skin. No other members of the family are affected.

Adolescent↗