Symposium on clinical drug evaluation and human pharmacology. VI. Difficulties in extrapolating data on metabolism of drugs from animal to man.
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Animals↗
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The analog computer and plasma drug kinetics.
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Computers, Analog↗
Equipment and methodology for relating gastrointestinal absorption to site of drug release.
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Drug Liberation↗
Kinetics of drug absorption, distribution, metabolism, and excretion.
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Biological Transport↗
Biopharmaceutics: absorption aspects.
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Biopharmaceutics↗
Pharmacology and biochemistry of drug metabolism.
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Humans↗
Illustrations and pharmaceutical interpretations of first order drug elimination rate from the bloodstream.
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Biological Transport↗
[Acceleration of oxidation of drugs during and after treatment with luminal].
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Humans↗
The biosynthesis of 6-azauracil riboside by Escherichia coli growing in the presence of 6-azauracil.
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Antineoplastic Agents↗
Drugs which alter the metabolism of vasoactive monoamines.
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Amines↗
The metabolism of drugs by regenerating liver.
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Enzymes↗
Inhibition of microsomal drug metabolic pathways by chloramphenicol.
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Chloramphenicol↗
Enzymic ribosidation and ribotidation of 5-fluorouracil by extracts of the Ehrlich-ascites tumor.
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Antineoplastic Agents↗
The biosynthesis of patulin. II. The general physiology of several strains of Penicillium patulum.
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Anti-Bacterial Agents↗
On the mechanism of absorption of drugs from the gastrointestinal tract.
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Gastrointestinal Tract↗
Cytochemical and cytological studies of drug action.
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Cells↗
Mode of action of alkylating agents: formation of S-ethylcysteine from ethyl methanesulphonate in vivo.
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Alkylating Agents↗
Pharmacological methods of estimating inhibition of drug oxidation in the mouse.
Three pharmacological techniques for measuring inhibition of "non-specific" oxidase activity in the mouse are described: (1) potentiation of pentobarbitone hypnosis, (2) potentiation of chlorpromazine hypothermia; and (3) reduction in the toxicity of octamethylpyrophosphorodiamide (schradan). Iproniazid, isoniazid, and beta-diethylaminoethyl 3,3-diphenylpropylacetate (SKF 525A) gave comparable results in all three tests.
Animals↗