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At least 19 recordsLinked to original sources

Toxic effects of dental materials.

Dental materials and clinical accessories may potentially cause adverse reactions in dentists, auxiliaries or patients. The introduction of new dental materials and a general awareness of adverse effects has been accompanied by an increase in the number of complaints related to dental treatment and to occupational exposure. Resin-based materials with various monomers, used as restorative composite materials, orthodontic adhesives and appliances, prosthodontic resins and impression materials, have all been involved. Reactions to metals used in extra-oral appliances in orthodontics seem to be relatively frequent, but few reactions have been reported following the use of other alloy systems. Some reactions may be due to toxic or allergic effects, but some are unexplained. Adverse reactions to any substance will usually be detected first in a setting where the exposure is greatest. This also holds true for dentistry, where some of the adverse reactions may be due to lack of knowledge about the toxic, irritant and allergenic properties of dental materials.

Allergens↗

Reactions of the gingiva to dental materials.

Dental materials may alter the health of the gingiva in different ways. In the etiology of periodontal disease dental materials are one factor only among several others. Today, excellent methods are available for the biologic evaluation of materials and it should no longer be possible to sell and introduce entirely new materials without any preclinical biologic testing. Financial gain cannot be an excuse for the exposure of man to the possible toxic, allergenic and even tumorigenic risks. Restorations with subgingival margins should be avoided and if they have to be done, amalgam, phosphate, silico-phosphate, silicate, resin, cold curing resin and pyroplast should not be used.

Animals↗

Biological evaluation of dental materials.

Dental materials and devices are being treated more like drugs and now have to meet the safety and efficacy requirements of drugs and medical devices. Biocompatibility is the key word. The history of the development of controls, standards, and guidelines began almost 500 years ago and is detailed in a chronological fashion up to the present time. An outline of the latest revised draft of the international document (ISO Technical Report No. 7405), to be completed hopefully by 1993 in time for the harmonization of the European Standards within the EC, is presented. The types of tests (initial, secondary, and preclinical usage tests) are listed and described. No amount of experimental study can guarantee absolute safety for any substance. However, toxicological investigations provide data from which reasonable projections and predictions can be made about the conditions under which the product can be safely used. It is the intent that this Technical Report be reviewed regularly and revised, with the ultimate objective of converting it to an International Standard.

Animals↗

[Allergies to dental materials and dental pharmacologic agents].

Allergic reactions to dental materials and remedies cause stomatitis in the patient and a contact dermatitis in the dental personnel. Topical contact (acrylic resin denture materials, heat accumulation, plaques on the denture) and endogenic (symptom of internal and psychiatric illnesses) factors are the cause for denture sore mouth. In metallic alloys corrosions and electric currents can effect an irritation to the oral mucosa. The application of amalgam fillings can possibly result in a mercurialism. Dental remedies used for treatment of wounds and dental roots are potent sensitizers. Surface anesthetics with tetracaine are the most frequent contact allergens for dentists. Injectable local anesthetics produce anaphylactic type reactions as well as toxic side-effects in the patient.

Anesthesia, Dental↗