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At least 19 recordsLinked to original sources
PubMed1998

Neonatal cryoanesthesia affects the morphology of the visual cortex in the adult rat.

Hypothermia is often employed as an anesthetic for manipulations of neonatal animals. We previously reported [J. Nuñez, J.M. Juraska, The effect of neonatal cryoanesthesia on the gross size of the splenium of the corpus callosum, Dev. Psychobiol. 30 (1997) 259; J. Nuñez, J.M. Juraska, The size of the splenium of the rat corpus callosum: influence of hormones, sex ratio and neonatal cryoanesthesia, Dev. Psychobiol., in press.] that the area of the splenium of the adult rat corpus callosum negatively correlated with the time neonatal pups spent in the cold. In the present study, we examined the effect of exposure to neonatal hypothermia (0, 15, 30 and 60 min at 4 degreesC, within 2 h of birth) on the thickness and volume of the binocular (Oc1B) and monocular (Oc1M) fields of the adult rat visual cortex. The number of neurons and glia in layer 2/3 in these areas was also assessed in the 0 and 60 min cold-exposed groups. Cryoanesthesia significantly decreased the length, thickness, volume and number of neurons and glia in both Oc1M and Oc1B. We also observed significant effects of cold exposure on the thickness of individual cortical layers, with some layers affected more than others after differential exposure times. Sex differences (males greater than females) were observed in a number of measures after varying amounts of time in cold and in the absence of cold exposure, in confirmation of previous work from our lab [S.N.M. Reid, J.M. Juraska, Sex differences in the gross size of the rat neocortex, J. Comp. Neurol. 321 (1992) 442-447; S.N.M. Reid, J.M. Juraska, Sex differences in neuron number in the binocular area of the rat visual cortex, J. Comp. Neurol. 321 (1992) 448-455.]. The present study points to the potential confound of using cryoanesthesia on neonatal animals to study cortical structure or function.

Aging↗
PubMed2000

Hippocampal anatomy and water maze performance are affected by neonatal cryoanesthesia in rats of both sexes.

There is recent evidence that cryoanesthesia, commonly used during neonatal hormone manipulations (e.g., gonadectomy), has deleterious effects on the morphology of the splenium of the corpus callosum and primary visual cortex in adult rats of both sexes. (Nuñez and Juraska, 1998; Nuñez, Kim, and Juraska, 1998). In the present study, the effect of neonatal cryoanesthesia on the morphology of the hippocampus and dentate gyrus and on performance in the Morris water maze was investigated. Cold exposure for as brief as 30 min (5 degrees C) on Postnatal Day 1 resulted in a significant decrease in the volume of the hippocampus and in brain weight of adults. Performance on the water maze was also impaired in cold-exposed animals. This study indicates that not only morphology but also behavioral performance in adulthood are affected by neonatal cryoanesthesia.

Adjuvants, Anesthesia↗
PubMed1994

[Cryoanesthesia by freon spray for venepuncture in children].

This prospective study was designed to assess the quality of skin analgesia provided by cryoanesthesia induced by a spray of freon (dichloro-tetrafluoro-ethane) for venous cannulation (22 or 24 Gauge cannulas). Eighty children between the ages of 5 and 15 years were allocated to two groups: 40 children had a conventional venepuncture, 40 others had a venepuncture under cryoanesthesia. The spray of freon was applied for ten seconds on the area of skin to be anaesthetised. The venous cannulation was carried out by an anaesthetist of the paediatric surgical unit. The intensity of pain at venepuncture was quantified with a visual analogic scale (range 0 to 100). The median values of the pain scores were 11.5 (0 to 50) in the cryoanesthesia group and 48 (11 to 75) in the control group respectively. It is concluded that freon spray provides a convenient analgesia for venepuncture in children aged 5-15 years.

Adolescent↗
PubMed1988

Below-knee physiologic cryoanesthesia in the critically ill patient.

Controversy has surrounded the role of local hypothermia as a preoperative treatment in amputations of the lower extremity. A study was undertaken to determine the effectiveness of amputation under cryoanesthesia in decreasing postoperative morbidity and mortality in below-knee (BK) amputations. Of 154 BK amputations, only 91 with unreconstructable vascular disease, gangrene, or both, were included in this study. Group I consisted of 48 patients (mean age 63.9 years) who had undergone a routine BK amputation; group II consisted of 43 patients (mean age 65.7 years) who were acutely ill and too unstable to undergo a major surgical procedure. Group II patients were treated by amputation while under cryoanesthesia before any definitive operative intervention. The patients in group II were significantly (p less than 0.05) more ill preoperatively than those in group I. Group II patients had a higher prevalence of previous myocardial infarction, previous stroke, diabetes mellitus, osteomyelitis, and wet gangrene. Seventy percent of the patients in group II had three or more risk factors vs. 46% in group I. Early postoperative mortality rates did not differ significantly between groups (group I, 8%; group II, 9%); the average length of hospital stay for group I patients was 24.2 days compared with 17.7 days in group II. Group II patients sustained slightly more postoperative complications. Amputation under cryoanesthesia appears to be of value in reducing postoperative morbidity and mortality and length of hospital stay in the acutely ill patient with unreconstructable vascular disease, gangrene, or both.

Aged↗
PubMed1998

The size of the splenium of the rat corpus callosum: influence of hormones, sex ratio, and neonatal cryoanesthesia.

The splenium (posterior 1/5) of the corpus callosum is sexually dimorphic in the adult rat brain. In the present study we examined the role of developmental hormones and cryoanesthesia (which is normally used during the performance of neonatal hormone manipulations) on the gross size of the splenium in male and female rats. There was a sex difference in splenial size (male > female) among nonhormonally manipulated animals, p = .0007. While neonatal castration was ineffective in altering the size of the male splenium, testosterone injections in females were found to increase the size of the splenium relative to oil-injected females, p = .05. The effect of developmental testosterone was further observed: Sex ratio (males to females) of the litter correlated with splenial area in females, r = .55, p = .03. Duration of cryoanesthesia negatively correlated with splenial area in males, r = -.81, p = .03, with a similar trend in females.

Animals↗
PubMed1999

Cutaneous cryoanesthesia does not affect histopathology of biopsy specimens.

Localized freezing of skin lesions in situ is widely used by dermatologists to provide anesthesia prior to excision or curettage. To determine whether this technique adversely affects the interpretation of biopsy specimens, we compared the histopathologic features of frozen and unfrozen portions of nine skin lesions, eight seborrheic keratoses, and one basal cell carcinoma. We detected no differences in the histopathologic features between the frozen and unfrozen portions of the lesions. We conclude that the technique of cutaneous cryoanesthesia does not adversely affect the histopathologic evaluation of skin lesions.

Biopsy, Needle↗
PubMed1985

Cryoanesthesia and electrosurgical treatment of benign skin tumors.

Liquid nitrogen spray followed by light electrodesiccation treatment is helpful in the management of flat warts, small skin tags, seborrheic keratoses, and cherry angiomas. Patients experience minimal discomfort and the procedure can be rapidly completed with excellent cosmetic results.

Electrosurgery↗
PubMed2001

Cryoanethesia on postnatal day 1, but not day 10, affects adult behavior and cortical morphology in rats.

Hypothermia was used to induce anesthesia in infant rats on postnatal days 1 or 10. In adulthood measures of spatial learning and activity were taken before the brains were harvested for measurement of cortical thickness and dendritic arborization in layer III pyramidal cells in parietal cortex. Cryoanethesia on day 1, but not day 10, produced a small, but statistically significant, impairment in learning a spatial navigation task as well as a reduction in cortical thickness and dendritic arborization. This study confirms that cryoanesthesia is not a benign treatment in newborn pups but appears to be without effect in older animals. It is important that all studies using cryoanesthesia have sham control animals exposed to the same degree of hypothermia.

Age Factors↗
PubMed1979

[Conditions for greater survival of neonatally thymectomized Swiss mice (author's transl)].

A total of 385 albino Swiss mice, of both sexes, between 24 and 30 hours of age are neonatally thymectomized, by means of a suction pump method. One batch is operated under ether anesthesia, another with sodium pentobarbital, and a third one with Cryoanesthesia. The last batch is subdivided into 2. In one of these the mother is anesthetized with sodium pentobarbital intraperitoneally, during the postoperative recovery of the litter, and in the other the mother is left without treatment. The mothers of the first two batches of thymectomized animals are anesthetized with the same products as their offspring. The percentage of survival of thymectomized breeding mice in greatest in the batch operated under Cryoanesthesia and whose mothers received the above mentioned treatment. Statistically the differences are very significant and they might be accounted to the fact that the mothers are anesthetized while their offspring normalize their physiological constants with better recovery in feeding, hydration, shelter and rest.

Anesthesia, General↗
PubMed2000

Neonatal halothane anesthesia affects cortical morphology.

Neonatal cryoanesthesia has recently been documented to affect morphology and behavior after a single exposure [Dev. Brain Res. 111 (1998) 89; Horm. Behav. 37 (2000) 169]. In the current experiment, we investigated the effect of one-time exposure to halothane inhalant anesthesia on neonatal rats of both sexes. Fifteen minutes of exposure on postnatal day one resulted in detectable changes in the volume of the visual cortex at 3 months. Thus, neonatal halothane alters neural development and its effects are observable in the adult rat.

Anesthesia↗
PubMed1988

Determining safe limits for untransfused, outpatient liposuction: personal experience and review of the literature.

Limiting liposuction volumes to avoid transfusion is sound surgical practice. Although the plastic surgery literature reports frequent use of transfusions in liposuction surgery, dermatologists almost never use blood replacement after liposuction. Techniques which favor less bleeding include sufficient use of fresh epinephrine, cryoanesthesia, use of smaller cannulas, fluid preloading, proper preoperative evaluation, serial liposuction, intramuscular steroids, and rapid application of pressure garments. A review of the literature and personal experience are detailed.

Ambulatory Surgical Procedures↗
PubMed1988

Anesthesia for liposuction in dermatologic surgery.

Liposuction is now a well-established procedure in dermatologic surgery. The relative advantages and risks of the various forms of primary anesthesia and supplemental analgesia used for liposuction surgery in the office by dermatologic surgeons is described. Effective anesthetic techniques include infiltration of local anesthesia (LA) with or without intramuscular (IM), intravenous (IV), or nitrous oxide sedation, cryoanesthesia, and IV or inhalation general anesthesia (GA). Local anesthesia, using large volumes of dilute anesthetic solution containing lidocaine (0.05%), epinephrine (1:1,000,000), and sodium bicarbonate (12.5 meq/L), is a safe and effective modality for liposuction by dermatologists. In a study of 12 liposuction patients treated with this technique, the average lidocaine dose was 1181 mg (9.4 mg/kg/hr). The highest peak lidocaine blood level among all patients was 0.484 microgram/ml. Dermatologists should not assume the dual responsibility of surgeon and of monitoring patients given IV sedation. Any form of anesthesia has the potential for serious complications. The surgeon and office staff must be well trained and equipped to perform emergency resuscitation.

Anesthesia↗
PubMed1992

The ice-saline-Xylocaine technique. A simple method for minimizing pain in obtaining local anesthesia.

Prior to skin surgery, localized cryoanesthesia is initially obtained utilizing Cryogel packs before local anesthesia injection, minimizing or abolishing pain from the piercing of the skin by the injection needle. The surgical field is then infiltrated with benzyl alcohol-containing normal saline, a painless solution producing moderate local anesthesia. Subsequently, a stronger anesthetic containing a vasoconstrictor or other desired additives can be infiltrated without significant patient discomfort. This simple three-step method has resulted in excellent patient acceptance, and is potentially useful for a wide range of surgical procedures and medical specialties.

Anesthesia, Local↗