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PubMedDate not supplied

Human infections with Actinomyces pyogenes (Corynebacterium pyogenes).

Actinomyces pyogenes (Corynebacterium pyogenes), a well-known pathogen in many animals, was isolated from 11 Danish patients since 1968. Bacteriologic characteristics and clinical pictures of the patients are described. Ability to hydrolyze gelatine, to produce beta-glucuronidase, to reach with antisera against group-G streptococci, and to produce acid from xylose differentiates A. pyogenes from Arcanobacterium haemolyticum, with which it has at times been confused. Actinomyces pyogenes is an established, but often misrecognized, human pathogen that should be better known to clinical microbiologists.

Actinomyces↗
PubMed1982

Chemical studies as a guide to the classification of Corynebacterium pyogenes and "Corynebacterium haemolyticum".

The peptidoglycan of Corynebacterium pyogenes and "Corynebacterium haemolyticum" contained lysine as the dibasic amino acid. In addition, glutamic acid and alanine were detected in the hydrolysates. Thin-layer chromatographic analysis of whole-organism methanolysates of C. pyogenes and "C. haemolyticum" revealed the presence of single spots corresponding to simple non-hydroxylated fatty acid methyl esters. The major fatty acid structural types were straight-chain and monounsaturated acids. Menaquinones (vitamin K) were the sole respiratory quinones detected in C. pyogenes and "C. haemolyticum". The major menaquinone components in C. pyogenes were tetrahydrogenated with ten isoprene units. Tetrahydrogenated menaquinones with nine isoprene units, however, predominated in "C. haemolyticum". The results of the present study indicate that C. pyogenes should be excluded from the genus Corynebacterium: C. pyogenes can be accommodated in the genus Actinomyces but the taxonomic position of "C.haemolyticum " remains equivocal.

Chemical Phenomena↗
PubMed1977

[The Corynebacterium pyogenes infection of cattle. 2. Tenacity of Corynebacterium pyogenes].

Some common agents were tested for their effectiveness against Corynebacterium pyogenes. The pathogen proved most susceptable to Wofasteril. All germs were killed within ten minutes by a 0.005% solution. Equally good action was recorded from all the other tested agents as well (lactic acid, Lugol's solution, formalin, cupric sulphate, alcohol, and aethacridine. Other studies were conducted with the view to testing the survival capacity of Corynebacterium pyogenes in different media and storage conditions. The pathogen survived three months in routine media and mastitis secretion at room temperature. Regrowth of 38 in 50 strains took place after nine months of refrigerator storage in slanting blood agar tubes with paraffin plugs. Germs sampled from mastitis secretion and stored in a refrigerator were cultivable even after one year had elapsed. The detectability rate of Corynebacterium pyogenes did not change over months by storage of wound infection material at 12 degrees C below zero. The pathogen remained detectable five days from artificial contamination of cattle skin.

Animals↗
PubMed1982

Reclassification of Corynebacterium pyogenes (Glage) in the genus Actinomyces, as Actinomyces pyogenes comb.nov.

Corynebacterium pyogenes (Glage) differs to such an extent from the type species of Corynebacterium, Corynebacterium diphtheriae (Lehmann and Neumann), that it cannot be retained in this genus. Numerical phenetic and chemical data indicate a close relationship between Corynebacterium pyogenes and the species Actinomyces bovis (Harz). It is proposed that Corynebacterium pyogenes be reclassified in the genus Actinomyces, as Actinomyces pyogenes (Glage) comb.nov.

Actinomyces↗
PubMed1988

Identification of Actinomyces (Corynebacterium) pyogenes with the API 20 Strep system.

A total of 62 strains of Actinomyces pyogenes (previously Corynebacterium pyogenes) were examined by the API 20 Strep system (API System, La Balme Les Grottes, Montalieu-Vercieu, France). The system was shown to be reliable and rapid when the tests were compared with standard identification methods. No confusion occurred with streptococcal profiles in the current API 20 Strep data base.

Actinomyces↗
PubMed1982

Endemic leg ulcers caused by Corynebacterium pyogenes in Thailand.

Corynebacterium pyogenes was isolated from leg ulcers found in 495 school children during an epidemic in Thailand in 1979 and 1980. Although C. pyogenes is frequently isolated from cattle, sheep, pigs, and goats, and less frequently from rabbits and guinea pigs, it rarely infects humans, where respiratory infections far outweigh skin infections. Cutaneous infections usually begin with a superficial abscess, then a frostbite-like lesion, followed by ulceration and even gangrene.

Adolescent↗
PubMed1977

[The Corynebacterium pyogenes infection in cattle. 1. Incidence of the pathogen].

Reported are the incidence of Corynebacterium pyogenes together with different pathological changes as well as the existence of latent Corynebacterium pyogenes infections and their widespread occurrence. Corynebacterium pyogenes was established from 609 in 2,130 samples of pathological processes, accounting for 28.6%. The pathogen was cultivated from various processes, including enlarged tail lymph nodes (61.1%), tail phlegmons (56.3%), abscesses (49.1%), epiphysiolyses (45.2%), liver abscesses (31.8%), panaritia at beginning of fattening (20.5%), aborted foetuses (14.9%), foetal membranes in cases of incarcerated placenta (12.0%), and panaritia on end of fattening (3.4%). The same pathogenic microorganism was recorded from nine per cent of apparently intact heifer udders, before pasturing. Corynebacterium pyogenes was cultivated also from nasal mucous membrane (8.4%) and retropharyngeal lymph nodes (37.2%). The highest detection rate was 71.6%, obtained from the tonsils.

Animals↗
PubMed1982

Nutritional requirements of Corynebacterium pyogenes.

The nutritional requirements of Corynebacterium pyogenes (strains C100, 5, and 1909), a commonly encountered animal pathogen, were determined in this study. A semidefined medium (SDM) containing glucose, HCO3-, hemin, charcoal-treated Trypticase, and a defined mixture of purines and pyrimidines, amino acids, and minerals which supported optimal growth of C. pyogenes was employed in all nutritional studies. Adenine and uracil were required for optimal growth of strains 5 and C100 but were not required for strain 1909. Riboflavin and nicotinic acid were required for good growth of all three strains; biotin and thiamin were stimulatory but did not appear to be required for growth. Hemin and NaHCO3 were stimulatory for growth, whereas lipoic acid and Tween 80 were neither stimulatory nor required for growth. The replacement of Trypticase with a specific peptide fraction (obtained by fractionation of Trypticase on Sephadex G-25) rich in dipeptides gave growth comparable to that in SDM, indicating a peptide requirement for the growth of C. pyogenes. It was of considerable interest that growth comparable to that in SDM was obtained when Trypticase was replaced by inositol (1 microgram/ml of SDM).

Amino Acids↗
PubMed1987

Corynebacterium pyogenes mastitis outbreak in inbred heifers in a California dairy.

An outbreak of Corynebacterium pyogenes mastitis ("Summer Mastitis") was observed in a group of 96 heifers. The outbreak affected 8 animals, of which 7 were too young for breeding. The disease incidence was highest in calves 2 to 4 months old. Cases were observed over an initial estimated 14 day period with a further case being detected 14 days subsequently. Corynebacterium pyogenes mastitis has not been reported in calves this age. Factors postulated to influence the outbreak include the presence of large numbers of flies, intersucking of calves, and possible viral disease.

Animals↗
PubMed1982

[Abortions in cows caused by Corynebacterium pyogenes].

Bacteriologic investigations of embryos, fetuses, and placentae of cows that had miscarried, uterine and milk samples taken from animals with endometritis and mastitis, and bull semen samples revealed the presence of Corynebacterium pyogenes. It was established that this organism ranks first in the group of occasionally pathogenic microflora that was associated with the occurrence of abortions in cows. It was isolated from in 9.2 per cent of the cases from fetuses, 5.3 per cent of the cases from embryos, and 8.1 per cent of the cases from placentae. On farms with records of Corynebacterium pyogenes abortions all endometritis and mastitis cases could be associated with the same infection. The organisms was demonstrated in the uterine secretion in both clinically normal cows and bull semen. Corynebacterium pyogenes was found to be viable for a long time, and, therefore, represented a serious source of infection--abortions, endometritis, and mastitis.

Abortion, Septic↗
PubMed1982

Physiological and nutritional features of Corynebacterium pyogenes.

Growth and acid metabolic products were similar when Corynebacterium pyogenes was grown aerobically or anaerobically in a serum-free medium (SFM). This indicated that C. pyogenes obtains energy for growth primarily by fermentative metabolism even under aerobic growth conditions. Growth yield was reduced by 90% in SFM minus glucose, 50% in SFM minus NaHCO3, 90% in SFM minus yeast extract, 100% in SFM minus Trypticase and yeast extract, and 30% in SFM minus haemin or Trypticase. Growth was not detectable when a known mixture of amino acids, vitamins, and nucleic acid bases were substituted for Trypticase and yeast extract in SFM; addition to the latter medium of a peptide source such as Trypticase or casitone supported good growth of the organism. When NaHCO3 was omitted from SFM and dissolved CO2 in the medium was rigorously excluded, growth was undetectable indicating that C. pyogenes has an obligate requirement for CO2 for growth. Succinate, formate and acetate were the major fermentation products in SFM, whereas in SFM minus HCO-3 or haemin, lactate was the major product and only small quantities of other acids accumulated.

Aerobiosis↗
PubMed1982

Morphology of sulfur granules produced by Staphylococcus aureus and Corynebacterium pyogenes in cows.

Sulfur granules produced by Staphylococcus aureus and Corynebacterium pyogenes were studied by light and electron microscopy. They consisted of bacteria and electron-dense amorphous substance which formed clubs in the periphery of each granule. In those produced by Staph. aureus, cocci were seen at the center of each granule. They were round or pleomorphic. Binary fission was frequently observed. In those produced by Coryn. pyogenes, degenerative bacteria were present at the center of each club. Bacteria found just beneath the club had a thick, electron-less-dense cell wall and electron-dense cytoplasm. Those present at the center of the granule were very long and had a cell wall thin and sometimes undulant, containing ribosomes. The electron-dense amorphous substance surrounded these bacteria and faced the neutrophils or epithelioid cells in the periphery of the granule both species of organisms. They might have been produced by bacteria. Cellular reactions of neutrophils, epithelioid cells, fibroblasts and plasma cells were seen around the sulfur granules produced by both species of organisms.

Animals↗