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At least 19 recordsLinked to original sources
PubMed1988

[Antidotal and antineoplastic properties of copper sulfate].

Copper sulfate in peroral administration to small experimental animals has an inhibitory effect on the growth of transplanted solid tumors and possesses antidote properties in respect to cisplatin. An antitumor effect of the compound was registered at doses ranging from 10 to 120 mg/kg. Antidote properties are manifested clearly when copper sulfate is applied at a single dose 10 mg/kg, 24 hours before cisplatin administration. It has been determined that copper sulfate decreases acute toxicity, nephro- and hemotoxicity of cisplatin, but fails to change its antitumor effect. The experimental data obtained give the ground for the clinical studies of copper sulfate.

Animals↗
PubMed1999

Copper status of ewes fed increasing amounts of copper from copper sulfate or copper proteinate.

The Cu status of mature, crossbred ewes fed two sources (CuSO4 vs. Cu proteinate) and three levels (10, 20, or 30 mg/kg) of dietary Cu was determined in a 73-d feeding trial. Ewes (n = 30) were fed a basal diet containing rice meal feed, cottonseed hulls, cottonseed meal, meat and bone meal, cracked corn, and vitamin-mineral supplements at 2.5% of BW to meet NRC requirements for protein, energy, macrominerals, and microminerals, excluding Cu. The basal diet contained 5 mg/kg Cu, 113 mg/kg Fe, .1 mg/kg Mo, and .17% S. Copper sulfate or Cu proteinate was added to the basal diet to supply 10, 20, or 30 mg/kg of dietary copper in a 2x3 factorial arrangement of treatments. Ewes were housed in 3.7- x 9.1-m pens in an open-sided barn. Blood samples were collected on d 28 and 73. Ewes were slaughtered on d 74, and liver and other tissues were collected to determine Cu concentrations. An interaction (P = .08) occurred between source and level for liver Cu. The interaction existed due to an increase in liver Cu concentrations when ewes were fed increasing dietary Cu from CuSO4 but not when fed Cu proteinate diets. There was no source x level interaction (P>.10) for the blood constituents measured. On d 73, plasma ceruloplasmin activity was greater (P<.05) in ewes fed Cu proteinate than in those fed CuSO4 (33.1 vs. 26.8 microM x min(-1) x L(-1)). Increasing the concentration of dietary Cu did not affect (P>.10) plasma ceruloplasmin. Packed cell volume (PCV), red blood cell count (RBC), white blood cell count, whole blood hemoglobin (wHb), plasma hemoglobin, and plasma Cu were similar between sources of Cu. Ewes fed 20 mg/kg Cu had lower (P<.05) PCV, RBC, and wHb than those fed 10 or 30 mg/kg Cu diets. Feeding up to 30 mg/kg Cu from these sources did not cause an observable Cu toxicity during the 73-d period.

Animal Feed↗
PubMed1995

[Absence of litholytic effects of zinc sulfate and copper sulfate in experimental lithiasis in rats].

Seventy two male Wistar-strain rats were fed lithogenic diet with ethylene-glycol within three weeks. At the end of this treatment, six rats were killed in order to determine the oxalate and calcium concentrations in renal tissue. Remained rats was randomly divided in four series, each series consisting of three groups. In first series (T), the animals were treated with distilled water; in the second (D1Zn), the animals were treated intramuscularly with the zinc at the rate of 24 micrograms per 100 grams of body weight and per day; in the third (D2Zn), 240 micrograms of zinc were administrated to animals and in the last series (D2Cu), the animals were treated at the same dose as the previous series, but with the copper. The groups which making up each series were killed successively at the 5th, 10th and 15th day after ending treatment with ethyleneglycol in order to determine urinary pH, percentage of water in renal tissue, uremia and concentrations of oxalate and calcium in renal tissue. Then, the comparisons of means were carried out, at each time, between different treated groups and reference group which was treated with distilled water. Litholytic effect was found in all series, including that which had been treated with distilled water. However, compared to reference animals, no acceleration of litholytic process was induced by zinc or copper. The high doses used in these experimentations proved therefore that calcium oxalate calculi were insoluble by zinc and copper.

Animals↗
PubMed1993

Effect of copper level and source (copper lysine vs copper sulfate) on copper status, performance, and immune response in growing steers fed diets with or without supplemental molybdenum and sulfur.

One hundred twenty-six crossbred steers (218 kg initial BW) were used to determine the availability of Cu from copper lysine (CuLys) relative to CuSO4. Steers were assigned to pens (four replicates per treatment) based on BW and initial plasma Cu concentration and fed a corn silage-based diet supplemented with 0 or 5 ppm of Cu from either CuSO4 or CuLys. Half of the steers in each treatment were supplemented with 5 ppm of Mo and .2% S. Molybdenum and S supplementation increased (P < .10) growth rate during the first 21 d. Steers receiving CuSO4 gained more during the first 21 d than did control steers (P < .10) and steers receiving CuLys (P < .01). Growth, feed efficiency, and feed intake were not affected over the entire 98-d trial. Molybdenum and S supplementation decreased (P < .05) plasma Cu concentrations. Plasma Cu concentration was not affected by Cu source. Humoral immune response to ovalbumin was measured on d 7 and 77. Dietary treatment did not affect antibody production at either time. Cell-mediated immunity was measured in vivo on d 7 and 77 using phytohemagglutinin. In vivo cell reactivity was not affected by treatment on d 7 but was reduced (P < .10) by Mo and S supplementation on d 77. In vitro cell reactivity was measured on d 98 using a lymphocyte blastogenesis assay. Unstimulated lymphocytes from steers supplemented with Mo and S had lower (P < .10) uptakes of [3H]thymidine. There were no differences among treatments when lymphocytes were stimulated with pokeweed mitogen or phytohemagglutinin.(ABSTRACT TRUNCATED AT 250 WORDS)

Animal Feed↗
PubMed1998

Tribasic copper chloride and copper sulfate as copper sources for weanling pigs.

We conducted three 28-d experiments involving a total of 915 pigs to assess the relative efficacy of tribasic Cu chloride (Cu2[OH]3Cl) and Cu sulfate pentahydrate (CuSO4.5H20) in diets for weanling pigs. Experiments 1 and 2 were conducted at an experiment station (University of Kentucky), and Exp. 3 was conducted at a commercial feed company's swine research facilities (United Feeds, Inc.). The basal diet was a fortified corn-soybean meal-dried whey diet (1.25% lysine) with no antimicrobials in Exp. 1 or with carbadox (55 mg/kg) in Exp. 2 and 3. In Exp. 1, 135 pigs were weaned at 27 to 31 d and fed the basal diet without or with 100 or 200 ppm Cu from Cu chloride, or 100 or 200 ppm Cu from Cu sulfate from 7.9 to 17.7 kg BW. The 200 ppm level of Cu from Cu sulfate improved ADG (P < .10), and both levels of Cu from Cu chloride tended to improve feed:gain. In Exp. 2, 150 pigs were weaned at 27 to 31 d and fed the basal diet without or with 100, 150, or 200 ppm Cu from Cu chloride, or 200 ppm Cu from Cu sulfate from 8.9 to 20.8 kg BW. Addition of 200 ppm Cu improved ADG (P < .08) and ADFI (P < .01), but not feed:gain. Source of Cu did not affect performance. In Exp. 3, 630 pigs were weaned at 16 to 20 d and fed a common diet for 10 to 12 d until the start of the experimental period. The same experimental diets as used in Exp. 2 were fed from 9.1 to 25.5 kg BW. Both Cu sources improved ADG (P < .01), and sources and levels of Cu did not differ. Liver Cu increased in pigs fed 200 ppm Cu, and Cu sulfate tended to increase liver Cu more than did Cu chloride in one experiment, but not in another experiment. The results indicate that tribasic Cu chloride is as effective as Cu sulfate in improving growth in weanling pigs.

Aging↗
PubMed1993

Comparison of copper lysine and copper sulfate as copper sources for ruminants using in vitro methods.

Two in vitro experiments were conducted to estimate the availability of Cu from Cu Lys compared with Cu from CuSO4. In experiment 1, a 24-h ruminal fermentation (alpha-cellulose substrate) containing either .1% added S or 2% added urea was performed with 4, 12, or 96 ppm of added Cu as either Cu Lys or CuSO4. Soluble Cu was measured at the end of the 24-h incubation, and concentrations were higher for Cu Lys with added urea (1.16 vs. .45 ppm), but no differences existed between sources of added S. In Experiment 2, 20 ppm of Cu added as either Cu Lys or CuSO4 with and without the addition of 10 ppm of Mo and .75% S were used in an vitro study designed to simulate digesta passage through the ruminant. A 24-h ruminal fermentation (orchardgrass substrate) was followed by a 2-h digestion in pepsin and HCl (pH 2.3) and then a 2-h digestion in NaHCO3 and pancreatin (pH 6.6). Soluble Cu concentrations were analyzed after each step. Molybdenum and S addition decreased soluble Cu after ruminal fermentation and tended to decrease soluble Cu concentrations after digestion of pancreatin and NaHCO3. The source of Cu did not affect soluble Cu concentrations. Results suggest that Cu from Cu Lys and CuSO4 behave similarly in the digestive tract of ruminants.

Animals↗
PubMed1995

Evaluation of copper sulfate and a copper lysine complex as growth promoters for weanling swine.

Two 5-wk trials using 176 weanling pigs (average initial weight of 8.3 kg and age of 31 d) were conducted to examine the effect of feeding varying levels of dietary Cu from copper sulfate (CuSO4) or a copper lysine complex (CuLys) on performance, mineral stores, serum copper, and serum mitogenic activity. Dietary treatments were 0 (15 mg/kg of Cu in basal diet), 100, 150, or 200 mg/kg of supplemental Cu from CuSO4 or CuLys. Average daily gain and ADFI increased linearly (P < .01) with increasing dietary levels of Cu during wk 1 to 2, 3 to 5, and 1 to 5, with no difference (P > .10) between the Cu sources. Overall gain:feed ratios were not consistently affected by Cu source. Dietary Cu linearly increased liver, kidney (P < .001), and brain (P < .05) concentrations of Cu. In the liver, the linear response to supplemental Cu differed between Cu sources (P < .001); pigs fed 200 mg/kg of Cu from CuLys had the highest concentration of Cu. Serum Cu concentrations increased linearly during wk 1 to 2 (P < .01), 3 to 5, and 1 to 5 (P < .001), with no difference (P > .10) between sources. Serum mitogenic activity increased linearly during wk 1 to 2 and 1 to 5 (P < .05). Growth performance was linearly improved as the dietary level of Cu increased from 15 to 200 mg/kg, with similar responses for both Cu sources. Serum and tissue concentrations of Cu were generally equally affected by the two Cu sources, except liver Cu concentration, which was onefold higher for pigs fed 200 mg/kg of Cu as CuLys.

Aging↗
PubMed1978

Site of emetic action of oral copper sulfate in dogs. (I) Thresholds of various portions of gastrointestinal tract to locally applied copper sulfate.

Emetic thresholds to copper sulfate administered into the Pavlov pouch, Forrest pouch, Thiry fistulas of the jejunum and ileum, and duodenal, jejunal and ileal catheters were measured in dogs to conjecture the site of emetic action of copper sulfate. The oral emetic threshold had been measured preoperatively. In the stomach, the pyloric antrum had a high sensitivity, while the corpus had a low sensitivity to the topically applied copper sulfate. In the intestine, the sensitivity was high in the duodenum, whereas a low sensitivity was noted in the jejunum. Almost no sensitivity was observed in the ileum. Thus it would appear that the site of the emetic action of copper sulfate was the pyloric antrum and/or duodenum.

Administration, Oral↗
PubMed1998

The effect of dietary supplementation with copper sulfate or tribasic copper chloride on broiler performance, relative copper bioavailability, and dietary prooxidant activity.

Three experiments were conducted to study Cu sulfate and tribasic Cu chloride (TBCC) as sources of supplemental Cu for poultry. In Experiment 1, 252 chicks were fed the basal corn-soybean meal diet (26 ppm Cu) supplemented with either 0, 150, 300, or 450 ppm Cu from Cu sulfate or TBCC for 21 d. Chicks fed 450 ppm Cu from sulfate had lower (P < 0.05) feed intake than those consuming other diets. Feeding supplemental Cu increased (P < 0.0001) liver Cu concentration linearly with increasing dietary Cu regardless of Cu source. The slopes of regression of log10 liver Cu on dietary Cu intake did not differ between sources (P > 0.10). Linear regression over nonzero dietary levels of log10 transformed liver Cu concentration (parts per million of DM) on analyzed total Cu intake (micrograms) resulted in a slope ratio estimate of 106+/-19 for bioavailability of Cu from TBCC compared to 100 for that in Cu sulfate. In Experiment 2, a 42-d floor pen study was conducted with 1,260 broiler chicks given the basal corn-soybean meal diet supplemented with 0, 200, 400, or 600 ppm Cu from either feed-grade Cu sulfate or TBCC. Body weight and feed conversion did not differ in birds fed up to 400 ppm Cu from either source. Birds given 600 ppm Cu from either source had lower feed intake, poorer growth, and feed conversion (P < 0.0001). Liver Cu increased (P < 0.0001) linearly with increasing dietary Cu. Based on log10 liver Cu concentration, Cu in TBCC was 112% available compared to 100% for the standard Cu sulfate. In Experiment 3, Cu sources were added to broiler starter diets at concentrations of 25, 100, and 300 ppm Cu and diets were stored at an elevated temperature to examine the effect of particle size on oxidation. Diets were stored at 37 C for up to 20 d and samples were removed at 4-d intervals. At 300 ppm added Cu, oxidation in TBCC diets was lower (P < 0.0001) than oxidation in diets fortified with coarse Cu sulfate, even though TBCC modal diameter for particle size was almost seven times smaller. Oxidation promotion by Cu sulfate was much greater with fine than in coarse sized particles for all three fortification levels.

Animal Feed↗
PubMed1996

Screening for anemia in pregnancy with copper sulfate densitometry.

OBJECTIVE: The copper sulfate method of screening for anemia was evaluated to determine its accuracy in antenatal patients. METHODS: In an antenatal clinic in a tertiary referral center, which also serves a local urban black community, 100 antenatal patients were prospectively tested for anemia by Coulter hemoglobin analysis in comparison with the copper sulfate test. The respective accuracy and costs of the tests were evaluated. RESULTS: Once initial technical difficulties had been overcome, the copper sulfate test proved accurate in detecting a hemoglobin level < 10 g% in pregnancy (sensitivity 94%, specificity 95%, positive predictive value 80%, negative predictive value 99%). The cost of the copper sulfate test is estimated to be less than 0.3% that of the Coulter test. CONCLUSION: The copper sulfate test is accurate and inexpensive, and can be recommended for screening for anemia in pregnancy.

Anemia↗