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At least 19 recordsLinked to original sources
PubMedDate not supplied

Cancer growth and progression in the framework of comparative oncology. A new approach to cancer therapy.

The influence of comparative oncology is most timely in view of the fact that there are significant intra- and interspecies differences in tumor development, tumor behavior and tumor reaction to various types of treatment, chemotherapy, radiotherapy, immunotherapy and multimodality-therapy. A comparison of the diverse processes which occur under normal, physiological, neoplastic and therapeutic conditions will result in a clearer understanding of tumor growth and progression. Similarly, it can be applied for selection of suitable treatment by enriching our knowledge about the progression of neoplastic diseases. Such a course will also enhance a general acceptance of the value of comparative oncology.

Animals↗
PubMed1992

Pet populations in the catchment area of the Purdue Comparative Oncology Program.

Using a 1-stage random-digit dial telephone survey, we estimated the number of pet dogs and cats and cancer case ascertainment in the principal catchment area of an animal tumor registry in Indiana, the Purdue Comparative Oncology Program (PCOP). These findings will assist in the estimation of pet cancer incidence rates for the PCOP. The estimated canine and feline populations for Marion County were 144,039 (95% confidence interval, 121,555 to 166,523) and 94,998 (74,384 to 115,648), respectively. For Tippecanoe County (excluding university housing residences), the estimated canine population was 18,000 (14,445 to 21,555), whereas the estimated feline population was 17,165 (12,569 to 21,761). The estimated cancer case ascertainment was 88.3% (dogs, 92.5%; cats, 83.0%) with no statistically significant difference in the estimated ascertainment by county of residence or by species of pet. The amount that owners report themselves willing to pay for treatment of cancer in dogs or cats, however, differed in counties polled. This method's appropriateness for estimating pet populations in general and the validity of the data gathered were supported by response rate of 88.0% and by concurrence with census data for household characteristics previously documented to be associated with pet dog and cat ownership.

Animals↗
PubMed1992

Characteristics of pet populations and households in the Purdue Comparative Oncology Program catchment area, 1988.

A 1-stage, random-digit dial telephone survey was conducted to obtain information on characteristics of pet populations and pet-owning households in 1988 in Marion and Tippecanoe Counties, Indiana. Interviews for 653 out of 731 eligible households were completed (response rate, 88%). Approximately half of the households in each county owned a pet. Of these, 35% owned at least 1 dog, and 23% owned at least 1 cat. Households with pets were more likely to be larger and have a higher median income score than were households without pets. Households with children between 6 and 17 years old were more likely to own pets than were households with no children; however, no difference in pet ownership proportions was determined for households with children < or = 5 years old, compared with households without children. For dogs, younger dogs and male dogs were less likely to have been neutered than older dogs and female dogs. Older cats were more likely to have been neutered than younger cats, with neutering percentages of > 90% for cats in the oldest age group. Approximately 20% of dogs and 40% of cats had not been seen by a veterinarian in the 12 months preceding the interview.

Adolescent↗
PubMed1982

[Canine osteosarcoma as a model in comparative oncology].

Osteogenic sarcomas constitute 80% of all bone tumors in dogs, i.e. approximately 4% of canine tumors. Canine and human osteosarcomas have many clinical and pathological features in common. Epidemiological studies have provided interesting data: larger canine breeds are subject to excess risk of primary bone sarcoma, probably as high as thirty times the risk in small dogs. The appendicular skeleton, namely the metaphyses of long bones, is a preferential initial site of the tumor, and this involvement increases with the weight class of the animals. These data suggest that body size, weight or growth rate may act as factors of bone sarcoma development. Therapeutic trials on canine osteosarcoma are ongoing and could be used as models for the human counterpart.

Animals↗
PubMed1996

Veterinary cancer epidemiology.

This paper reviews the impact of veterinary cancer epidemiology on veterinary oncology, human oncology, comparative oncology, and on the etiology and pathogenesis of cancer. The detection of clusters of diseased animals has led to the discovery of the infectious, viral-associated nature of malignant lymphoma of cats, poultry, and cattle. Although some viruses (FeLV, BLV) can, under experimental conditions, cross the species barrier, there is thus far no evidence for a zoonotic hazard for the human. The keeping of pet/birds or pigeons was found to be associated with an increased risk of lung cancer in the bird keepers. Dogs appear to be useful 'sentinels' for environmental hazards (asbestos, dyes, passive smoking, insecticides). The complex pathogenesis of cancer was dissected in an epidemiologic-experimental study in cows, which had intestinal papillomas and carcinomas. Endogenous genetic factors may also play a role in pathogenesis, as is evidenced by species, breed (Boxer!), and family related aggregates of tumour diseases. Epidemiology may provide a means to prevent tumour diseases by, for example, withdrawal of hormones (mammary cancer) or isolation of tumour-virus positive animals (malignant lymphoma).

Animals↗
PubMed1989

Patient-controlled analgesia in gynecologic oncology. A comparative analysis.

Patient-controlled analgesia (PCA) allows postoperative gynecologic oncology patients to self-administer intravenous analgesia but has not been well compared to standard intramuscular analgesia. Seventy patients undergoing laparotomy were treated with meperidine via PCA or intramuscular administration and evaluated 24 and 48 hours postoperatively. The 35 patients receiving PCA used statistically significantly less meperidine than did the controls at 24 and 48 hours postoperatively. The pharmacy's cost of the drug was statistically significantly less for PCA patients. PCA meperidine was well tolerated, with minimal alterations in consciousness and infrequent nausea.

Diagnosis, Differential↗