[A case of common bile duct neoplasm with carcinosarcoma of the gallbladder].
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Papillary adenocarcinomas remain at present some of the rare tumours of the biliary pathways. They raise numerous problems in connection with the diagnosis and with the surgical attitude. The authors present their personal experience acquired in 8 cases of papillary adenocarcinomas of the biliary pathways in which, after removal by curettage external biliary drainage was performed (4 cases, 2 survivals for 3 and 10 months respectively). Cholecystogastrostomy was performed in 2 cases and choledocoduodenostomy in two more patients (survivals of 3 and 20 months respectively).
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The Authors report their experience regarding two primitive tumours of the confluent and one tumour of the gall bladder involving the biliary confluent, all treated by major hepatic demolitions--one left hemihepatectomy and two extended right hemihepatectomies--with removal of the biliary tree en bloc and appropriate reconstruction. These highly demolitionary operations were performed with the aim of achieving greater radicality. The indications for such type of operation, dictated by notions of tumoral biology and reasons of surgical technique, are discussed. The Authors make a comparison of their experience with the data obtained from literature, which up to now reports only twenty-two; no statistical judgment on the effectiveness of the method is therefore possible, even if the results obtained and the theoretical presuppositions would seem to confirm its validity.
The clinical courses of 18 patients with extrahepatic bile duct carcinoma operated on between 1960 and 1979 are reviewed retrospectively. The preoperative and intraoperative diagnostic difficulties due to marked peritumor sclerosis are pointed out. The location of the lesion appeared to bear the most important relationship to prognosis: the lesions located in the upper and middle thirds of the extrahepatic biliary system are often invasive of adjacent vascular structures and, hence, unresectable, necessitating a proximal biliary-enteric anastomosis or intubation to alleviate jaundice and pruritus. A more aggressive operative approach, however, will result in a higher survival rate, as shown in personal experience for lower third lesions resected by Whipple's procedure.
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No changes in prognosis of extrahepatic bile ducts malignant tumors was observed in the last years, in spite of modern tomographic procedures: only occasionally an early diagnosis resulting possible. Jaundice is the presentation sign of the disease, allowing in most cases when the site of tumor is the papilla of Vater or distal common bile duct a radical surgery but only palliative procedures when the tumor arises in the gallbladder or at the hepatic duct junction. Survival data from literature and personal experience indicate limited late results for radical surgery together with high operatory mortality. In the field of palliative surgery transtumoral drains appear to offer better results.
A retrospective study is reported, carried out on 45 patients with primary carcinoma of the biliary tree. The purpose of the study was to test the effectiveness of US in accurately demonstrating the kind of jaundice (diagnostic level I), the site (diagnostic level II) and etiology of the biliary obstruction (diagnostic level III). A carcinoma of the gallbladder with common bile duct infiltration was found in 23 patients, while 22 were affected by primary bile duct carcinoma. In the 23 patients with carcinoma of the gallbladder, the kind of jaundice was correctly diagnosed in 100% of cases, while the site and cause of obstruction were detected in 18 (78%) and 10 (43%) cases respectively. In the 22 cases of primary bile duct carcinoma, the kind of jaundice was accurately demonstrated in 21 cases (95%); the site and etiology of the obstruction in 19 (86%) and 11 (50%) patients respectively. Therefore, in a total number of 45 patients examined, success rate was 98% in diagnostic level I, 80% in diagnostic level II, and 47% in diagnostic level III. Ultrasonography proves thus to be almost completely reliable in diagnostic level I, and very reliable in diagnostic level II; so much so that it can, alone, direct the surgeon in case of an emergency. Results are less satisfactory in diagnostic level III. Therefore, if details of the obstructive lesion and of the biliary tree are required for the planning of definitive treatment, either PTC, ERCP, or CT should be performed.