Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Chronic cough”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMed2026

The Genetic Architecture of Chronic Cough: From Sensory Hypersensitivity to Treatable Trait.

Chronic cough is a prevalent global clinical disorder with substantial quality-of-life impairment, and refractory cases remain a major unmet medical need. Cough hypersensitivity syndrome is the core pathological mechanism of chronic cough, and growing genetic evidence has confirmed that inherited susceptibility shapes cough hypersensitivity, clinical heterogeneity and therapeutic responsiveness, redefining chronic cough as a biologically mediated sensory-neural disorder rather than a non-specific secondary symptom of airway diseases. This review summarises genetic evidence for chronic cough from family-based studies, pharmacogenomics and genome-wide association studies (GWAS), revealing distinct genetic architectures of chronic dry cough and sputum production, with enrichment of sensory-neural pathway variants and key genetic loci such as replication factor C subunit 1 (RFC1) functional genomic analyses link genetic variation to vagal afferent excitability, and rare genetic neurological disorders further illuminate the neurogenic basis of cough hypersensitivity. Moreover, genetic insights identify tractable treatable traits and rationalise antitussive drug development, supporting genotype-guided patient stratification. We conclude that integrating genetic architecture into clinical phenotyping and translational research provides a critical framework for precision management of chronic cough, and future progress relies on harmonised deep phenotyping and multi-ancestry genetic studies.

RFC1 gene↗
PubMed1979

Prevalence and etiology of chronic cough without sputum production in coal miners.

Chronic cough in the sense of the international definition was found in 50.5% of a group of 970 coal-miners at work without pneumoconiosis. In 14.7% of these subjects the cough was without phlegm production. Non productive cough is therefore not a rare event and this symptom may not be neglected in the natural history of chronic bronchitis in coal-miners. The changes in lung function are similar whether the cough is productive or not. In both cases endoscopic and histological features are suggestive of an established chronic inflammatory process. Allergy is not more frequent in subjects with dry cough than in those with productive cough.

Bronchi↗
PubMed1979

Chronic cough as the sole presenting manifestation of bronchial asthma.

Six patients with chronic cough, without history of dyspnea or wheezing, had normal base-line spirometry but hyper-reactive airways, as demonstrated with methacholine. Maintenance therapy with bronchodilators promptly eliminated the cough in all patients. Three to 12 months later therapy was discontinued for three days, cough returned, and detailed pulmonary-function studies were carried out. Again, base-line values were normal, but after methacholine one-second forced expiratory volume decreased an average of 40 per cent in the patients as compared to 30 per cent in normal controls (P less than 0.001). The point of identical flow was increased by methacholine to 43.5 per cent of vital capacity in the patients, as compared to 6 per cent in normal controls (P less than 0.001), and the alveolar plateau was 4.8 deltaN2 per liter, as compared to 1.4 in normal controls (P less than 0.01). Specific airway conductance was lowered in patients and controls, but the post-methacholine value was significantly lower in the patients. On the basis of their persistently hyper-reactive airways, inducible diffuse airway bronchoconstriction and excellent response to bronchodilator therapy, these patients appear to have a variant form of asthma in which the only presenting symptom is cough.

Adolescent↗
PubMedDate not supplied

[Epidemiological study of chronic cough and obstructive ventilatory dysfunction in a rural area].

An epidemiological study (MRC--Questionnaire and spirography) has been carried out on a population aged between 40 and 69 years living in a rural area (Costeşti, district of Buzău). 440 subjects (202 men and 238 women; 83% of the population in this age group) were examined. Chronic productive cough in subjects with no other respiratory diseases was found in 8,9% of the examinated males and in 5.0% of the females. The figures are lower than those found in an urban population and in a previous survey in an other rural area. Obstructive syndrome (reduced FEV 1.0/VC ratio) was found in 5.0 and in 2.9%, respectively. More than half of the patients with obstructive syndrome had no cough; the lung function alterations found in these subjects may be due--at least in some cases--to the obstruction of distal airways which have no clinical manifestations in the early stages.

Adult↗
PubMed1978

[Chronic cough].

Explore the source record for details and available documents.

Asthma↗
PubMed1978

[Chronic cough].

Explore the source record for details and available documents.

Aged↗
PubMed1976

Chronic cough in young adults in relation to smoking habits, childhood environment and chest illness.

A survey of the respiratory symptoms and smoking habits of a population of 20-year-olds- followed since birth- was repeated when they reached the age of 25. The association of cough prevalence with current smoking habits and with lower respiratory tract illness in childhood found in the survey at age 20 was confirmed and in each instance appears to have increased in strength over the 5 years. At age 25, however, the prevalence of cough was associated at a statistically significant level with fathers' occupation; and this association with social class of origin could not be explained by persisting differences in social status based on the educational levels attained by early adult life. The association with exposure to air pollution in childhood, although more obvious than before, could be due to chance. The prevalence of cough increased between the ages of 20 and 25 among those who smoked throughout or who started to smoke during this period. It declined for those who never smoked and for those who were smoking at 20 but had given up by 25. The implications of these changing patterns of respiratory disease behaviour at a crucial stage between adolescence and adult life are briefly discussed.

Adult↗
PubMed1976

Antitussive activity of diphenhydramine in chronic cough.

A double-blind crossover study was conducted to evaluate the antitussive effectiveness of diphenhydramine (DPH) in chornic coughs related to bronchitis, at doses of 25 and 50 mg every 4 hr for four doses. Both 25- and 50-mg doses caused a statistically and clinically significant reduction in frequency of coughs, compared to placebo. The most frequently reported side effect was drowsiness, principally at the 50-mg dose level. There was little or no apparent correlation between antitussive effectiveness and incidence of drowsiness, however, suggesting that the two effects were pharmacologically unrelated.

Adult↗
PubMed1977

Quantitative relationships between cigarette smoking and chronic productive cough.

A close relationship between chronic productive cough and cigarette smoking was confirmed in an epidemiological study of airways obstructive disease in Tucson. Pack-years of smoking was closely related to symptom frequency and no threshold effect was noted. This relationship was affected by age and a history of childhood respiratory disease, but not by atopy. Among present smokers males and females did not differ significantly in their smoking habit specific rates of chronic productive cough, but males appeared to lose their symptoms less regularly than females when they quit smoking after many pack-years of cigarette use. When the relationship of smoking to chronic productive cough was removed, smoking was not significantly related to other aspects of 'chronic nonspecific respiratory disease' in this analysis.

Adolescent↗
PubMedDate not supplied

[Prevalence of chronic productive cough and obstructive ventilatory dysfunction in a rural community with minimal air pollution].

Results obtained during an epidemiological investigation on chronic cough and obstructive ventilatory dysfunction in subjects without bronchopulmonary affections of known etiopathogeny, carried out in a rural environment with minimal air pollution on 282 men aged between 40 and 69 years, indicate the following: --there was a lower prevalence of chronic cough in the rural environment as compared with the urban one (12.8:21.0). The percentage of heavy smokers being approximately similar in both environments, the difference could be explained by the variable intensity of air pollution, the impact of which was exerted on the large airways (hypertrophy of the serous-mucous glands resulting in hypercrinia with dyscrinia); --similar prevalence in the two environments of the obstructive ventilatory dysfunction (11,0:8,7) suggests that this abnormality, an expression of the narrowing of the small airways, could be due to other pathogenic factors. Functional pulmonary tests with sensitivity higher than the ratio between FEV 1.0 and VC (as, for instance VEmx 50% VC) could provide higher percentages of obstructive disturbances both among chronic coughing and non-coughing subjects, revealing the latent form of the obstruction, as opposed to the manifest one as evidenced by a decrease of the FEV 1.0/VC ratio.

Adult↗
PubMed1979

Aspirated foreign bodies in children.

Children six months to four years of age are at greatest risk for aspiration of foreign bodies. A history of coughing after contact with small objects is the most important clue. The clinical presentation varies from paroxysms of choking and coughing to chronic cough or wheezing. Chest radiographs are normal in up to one-half of the children. The location and size of the foreign body determine the urgency and selection of therapy. Prevention and a high index of suspicion will decrease morbidity.

Bronchi↗
PubMed1978

The Philadelphia Pulmonary Neoplasm Research Project. Symptoms in occult lung cancer.

In a prospective study of 6,027 older men screened every six months for ten years by means of chest photofluorograms and questionnaires regarding symptoms, 121 developed lung cancer after the first examination. Eighty-five men with lung cancer had the opportunity to be screened eight times before the tumor was detected by chest x-ray film, but only 33 actually reported that often. These 33 men were compared with matched controls for symptoms before the neoplasm was detected radiologically. The common symptoms of expectoration and chronic cough showed a significant increase in frequency over time in the cases of cancer, while only expectoration showed a slight increase in the controls. Uncommon symptoms more suggestive of lung cancer (hemoptysis and worsening cough) occurred in only four men prior to detection of cancer. Symptoms are seldom useful in the detection of occult lung cancer, but the appearance of expectoration and chronic cough in older male smokers should raise a suspicion of this disease.

Chronic Disease↗
PubMed1977

Respiratory symptom prevalence in adults: the comparative importance of smoking and family factors.

In a study of the prevalence of chronic cough and phlegm production in a group of nearly 4000 young adults, those adults who had several children had a higher prevalvalence of these symptoms than those with few children, especially if the children suffered from bronchitis or pneumonia. Nevertheless, cigarette smoking was the factor most strongly associated with chronic cough and phlegm production in young adults in this study.

Adult↗