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Results for “Chlormerodrin”

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At least 19 recordsLinked to original sources
PubMed1977

[Study of distribution of 203Hg-chlormerodrin, 203Hg-nitrate and 99mTc-DMSA in kidney by macroautoradiography (author's transl)].

Serial macroautoradiograms were obtained to determine the distribution of 203Hg-chlormerodrin, 203Hg-nigrate and 99mTc-DMSA in kidney. In the study, normal rats were used and these three radiopharmaceuticals were injected intravenously. Initial images of 203Hg-chlormerodrin showed the accumulation in the outer cortex, but no significant radioactivity in the medullary. On the other hand, delayed images revealed radioactivity shifting in concentration from the outer cortex to the inner cortex. Distribution pattern of 203Hg-nitrate was similar to that of 203Hg-chlormerodrin. In contrast to 203Hg-chlormerodrin and 203Hg-nitrate, 99mTc-DMSA was retained in the outer cortex without temporal changes in the distribution.

Animals↗
PubMed1979

Antimicrobial activity of chlormerodrin.

A radiochemical study for antimicrobial activity of chlormerodrin was performed using some commonly occurring nonpathogenic and pathogenic microorganisms. Chlormerodrin concentrations of 15-35 and 20-45 microgram/ml of the culture medium were microbiostatic and microbicidal, respectively. The microbiostatic effect was reversible in the presence of cysteine, an amino acid containing a sulfhydryl group.

Anti-Infective Agents↗
PubMed1970

The quantitative measurement of tubular chlormerodrin binding as an index of renal function: a study of 400 cases.

We have studied and found valuable a numerical value best designated as the "renal chlormerodrin uptake". This represents not a transient state, like the renogram, but a measurement of the biological ability of the renal tubules to firmly bind (203)Hg chlormerodrin presented to them as a very small standard dose passing through the kidney. Normal kidneys bind a remarkably fixed portion, and there is a consistent parallel between retention and tubular function.This binding, expressed for each kidney as a percentage of the normal, provides an easily measured value which allows isotopic renal measurements made from day to day and from year to year, on various individuals, to be accurately compared.These uptake values may be used to measure individual organ function or, by their addition, to evaluate the total renal function possessed by that patient. The utility of such uptake values goes beyond the conventional assessment of renal flow in hypertension, and is applicable to most forms of renal dysfunction, including trauma.Determination of the renal uptake at three to four hours fits well into a standard set of procedures which also includes the renogram, the renal scan, the local quantitation of scan areas, and the intravenous pyelogram. It requires only a few additional minutes, and no additional instrumentation or radiopharmaceuticals.

Chlormerodrin↗