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At least 19 recordsLinked to original sources
PubMed1987

Bioinorganic chemistry. Inorganic chemistry in a perspective of biology, medicine and the environment.

A brief overview of recent developments in the area of bioinorganic chemistry is presented. After a description of the field and the relationships with other disciplines, a short presentation of the historical developments in the field are discussed. The main part of the paper deals with a discussion of the current highlights and the applications of bioinorganic principles in other fields. At the end an expectation is presented of future developments.

Animals↗
PubMed2006

Biosynthetic inorganic chemistry.

Inorganic chemistry and biology can benefit greatly from each other. Although synthetic and physical inorganic chemistry have been greatly successful in clarifying the role of metal ions in biological systems, the time may now be right to utilize biological systems to advance coordination chemistry. One such example is the use of small, stable, easy-to-make, and well-characterized proteins as ligands to synthesize novel inorganic compounds. This biosynthetic inorganic chemistry is possible thanks to a number of developments in biology. This review summarizes the progress in the synthesis of close models of complex metalloproteins, followed by a description of recent advances in using the approach for making novel compounds that are unprecedented in either inorganic chemistry or biology. The focus is mainly on synthetic "tricks" learned from biology, as well as novel structures and insights obtained. The advantages and disadvantages of this biosynthetic approach are discussed.

Biology↗
PubMed2005

Carborane acids. New "strong yet gentle" acids for organic and inorganic chemistry.

Icosahedral carborane anions such as CHB11Cl11- are amongst the least coordinating, most chemically inert anions known. They are also amongst the least basic, so their conjugate acids, H(carborane), are superacids (i.e. stronger than 100% H2SO4). Acidity scale measurements indicate that H(CHB11Cl11) is the strongest pure Brønsted acid presently known, surpassing triflic and fluorosulfuric acid. Nevertheless, it is also an extremely gentle acid--because its conjugate base engages in so little chemistry. Carborane acids separate protic acidity from anion nucleophilicity and destructive oxidative capacity in the conjugate base, to a degree not previously achieved. As a result, many long-sought, highly acidic, reactive cations such as protonated benzene (C6H7+), protonated C60(HC60+), tertiary carbocations (R3C+), vinyl cations (R2C=C(+)-R), silylium ions (R3Si+) and discrete hydronium ions (H3O+, H5O2+ etc.) can be readily isolated as carborane salts and characterized at room temperature by X-ray crystallography.

Acids↗
PubMedDate not supplied

[A glimpse into a new discipline: medicinal inorganic chemistry].

Authors discuss some aspects of the medicinal application of metal complexes. They deal with anti-effective agents, bismuth anticulcer and gold antiarthritic drugs, and with agents that influence the NO balance in the cardiovascular system. Further, they concern with insulin mimetic vanadium compounds, metal complexes of superoxide dismutase activity, photodynamic therapy, and the treatment of copper deficiency.

Anti-Ulcer Agents↗
PubMed2006

Design of targeting ligands in medicinal inorganic chemistry.

This tutorial review will highlight recent advances in medicinal inorganic chemistry pertaining to the use of multifunctional ligands for enhanced effect. Ligands that adequately bind metal ions and also include specific targeting features are gaining in popularity due to their ability to enhance the efficacy of less complicated metal-based agents. Moving beyond the traditional view of ligands modifying reactivity, stabilizing specific oxidation states, and contributing to substitution inertness, we will discuss recent work involving metal complexes with multifunctional ligands that target specific tissues, membrane receptors, or endogenous molecules, including enzymes.

Antineoplastic Agents↗
PubMed2004

Polyoxometalates: from inorganic chemistry to materials science.

Polyoxometalates have been traditionally the subject of study of molecular inorganic chemistry. Yet, these polynuclear molecules, reminiscent of oxide clusters, present a wide range of structures and with them ideal frameworks for the deployment of a plethora of useful magnetic, electroionic, catalytic, bioactive and photochemical properties. With this in mind, a new trend towards the application of these remarkable species in materials science is beginning to develop. In this review we analyze this trend and discuss two main lines of thought for the application of polyoxometalates as materials. On the one hand, there is their use as clusters with inherently useful properties on themselves, a line which has produced fundamental studies of their magnetic, electronic or photoelectrochemical properties and has shown these clusters as models for quantum-sized oxides. On the other hand, the encapsulation or integration of polyoxometalates into organic, polymeric or inorganic matrices or substrates opens a whole new field within the area of hybrid materials for harnessing the multifunctional properties of these versatile species in a wide variety of applications, ranging from catalysis to energy storage to biomedicine.

Electrochemistry↗
PubMed2002

Applications of the Cambridge Structural Database to molecular inorganic chemistry.

Applications of the data in the Cambridge Structural Database (CSD) to knowledge acquisition and fundamental research in molecular inorganic chemistry are reviewed. Various classes of application are identified, including the derivation of typical molecular dimensions and their variability and transferability, the derivation and testing of theories of molecular structure and bonding, the identification of reaction paths and related conformational analyses based on the structure correlation hypothesis, and the identification of common and presumably energetically favourable intermolecular interactions. In many of these areas, the availability of plentiful structural data from the CSD is set against the emergence of high-quality computational data on the geometry and energy of inorganic complexes.

Journal Article↗
PubMed2005

Polyhedra in (inorganic) chemistry.

A systematic description of polyhedra with varying degrees of regularity is illustrated with examples of chemical structures, mostly from different fields of Inorganic Chemistry. Also the geometrical relationships between different polyhedra are highlighted and their application to the analysis of complex structures is discussed.

Journal Article↗
PubMed1989

Inorganic chemistry of chromium and its speciation in Whetlerite.

Chromium compounds are among the impregnants that enhance the ability of carbon air filters to absorb and destroy toxic agents such as CK and AC. The possibility of inhaling chromium-containing carbon dust from such filters has caused concern because, in addition to being an essential nutrient, chromium has been identified as a chemical carcinogen in humans. The essentiality or carcinogenicity of chromium depends upon its chemical speciation. Solubility and oxidation state are particularly important factors in assessing the potential hazards associated with the possible inhalation of chromium-containing dusts from these impregnated carbons or Whetlerites. The chemical speciation of the chromium in Whetlerite was found to be: from 0.6 to 1.3% insoluble trivalent chromium; from 1.0 to 1.3% insoluble hexavalent chromium; and from 0.7 to 0.9% soluble hexavalent chromium. The impregnation process, and the resulting speciation of chromium in Whetlerite, is consistent with the inorganic chemistry of chromium.

Air Pollutants, Occupational↗
PubMedDate not supplied

Inorganic chemistry of O2 in a dense primitive atmosphere

A simple steady-state photochemical model is developed in order to determine typical molecular oxygen concentrations for a comprehensive range of primitive abiotic atmospheres. Carbon dioxide is assumed to be the dominant constituent in these atmospheres since CO2 photodissociation may potentially result in the enhancement of the O2 partial pressure. The respective effects of the H2O content, temperature, eddy diffusion coefficient and UV flux on the results are investigated. It is shown that for any pressure at the surface, the partial pressure of molecular oxygen does not exceed 10 mbar. The peculiar case of a runaway greenhouse which has possibly taken place on Venus is qualitatively envisaged. Although O2 is basically absent in the present Venus atmosphere, a transient presence in a primitive stage cannot be ruled out. Possible mechanisms for O2 removal in such an atmosphere are reviewed. At the present stage, we think that the detection of large O2 amounts would be at least a good clue for the presence of life on an extrasolar planet.

Atmosphere↗