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The elderly show changes in various parenchymas linked to the process of ageing. Pathological abnormalities may be added to this picture leading to physiopathology peculiar to the aged. In relation to special problems raised by this background, the advantages and disadvantages of N.L.A. are discussed. The authors refer to an experiment in the Department of Anesthetics and Intensive Care in Créteil.
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The sorting out of biological cell mixtures into clusters of one cell type is modelled as a consequence of random cell and cluster motion, during which cells of like type cohere upon collision. After a description of the model and its motility rules, the results of several computer simulation studies are analysed and compared with both laboratory data and certain theoretical predictions. The model is found to be more biologically realistic than previous models with similar results. Suggestions for further reserach are discussed. An Appendix contains details about the data structures and algorithms employed in the simulation.
In this contribution a computer model is presented which enables a simulation of disturbed cell growth and cell renewal systems by means of a microprocessor system. The results consist of a time course study of the number of cells and of the local configuration of cells in a cell matrix at any arbitrary discrete moment. A similarity to morphological cuts and cell kinetic curves obtained by experiments is obvious.
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A model is presented for the statistical and geometrical aspects of the packing of cells. The model is closely related to lattice polymer models and the Ising model of ferromagnetism. Fundamental questions of existence and analyticity in the infinite volume limit are discussed, and the results of some initial numerical studies are given.
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