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At least 19 recordsLinked to original sources
PubMedDate not supplied

Cue reactivity in cocaine-dependent subjects: effects of cue type and cue modality.

Thirty cocaine-dependent subjects were enrolled into a cue-laboratory study to determine the specificity and sensitivity of this paradigm as a craving measure. Subjects experienced three cue types (i.e., cocaine, arousing, and neutral stimuli) in three cue modalities (i.e., audio, visual, and manual). Cue types were administered in different experimental sessions with a period of 2 to 3 days between sessions. Our results showed that subjective and physiological craving for cocaine was relatively specific for the cocaine cue as compared with either the arousing or the neutral cue. The relative sensitivities of the cue modalities in decreasing order was manual, audio, and visual. We suggest that a modified conditioned-cue paradigm could be a useful tool in the repeated assessment of craving during a clinical study.

Adult↗
PubMed2003

Olfactory and/or visual cues for spatial navigation through ontogeny: olfactory cues enable the use of visual cues.

This study analyzed the spatial memory capacities of rats in darkness with visual and/or olfactory cues through ontogeny. Tests were conducted with the homing board, where rats had to find the correct escape hole. Four age groups (24 days, 48 days, 3-6 months, and 12 months) were trained in 3 conditions: (a) 3 identical light cues; (b) 5 different olfactory cues; and (c) both types of cues, followed by removal of the olfactory cues. Results indicate that immature rats first take into account olfactory information but are unable to orient with only the help of discrete visual cues. Olfaction enables the use of visual information by 48-day-old rats. Visual information predominantly supports spatial cognition in adult and 12-month-old rats. Results point out cooperation between vision and olfaction for place navigation during ontogeny in rats.

Age Factors↗
PubMed2003

Using the cue-availability paradigm to assess cue reactivity.

BACKGROUND: A recent meta-analysis on cue-reactivity research revealed that cue-specific craving for alcohol is substantially less robust than craving measured for other drugs of abuse. The small effect sizes for alcohol underscore the need for more powerful methods of assessing cue reactivity in humans. The cue-availability paradigm is a modification of the conventional cue-reactivity paradigm and is intended to increase the sensitivity of measuring cue-reactivity to alcohol in humans. METHODS: Seventeen non-treatment-seeking alcoholics were tested individually on two different sessions (after priming with alcohol and after priming with placebo-alcohol). Subjects were presented with a total of 32 cue-availability trials. On each trial, subjects were presented with either a target cue (alcohol) or a neutral cue (water). Each cue was available for drinking on 50% of the trials (availability condition). Cue-reactivity measures were self-reports of craving and mood. RESULTS: The alcohol prime had a robust effect on craving. Irrespective of the availability of the cue for consumption or the type of cue, craving was consistently higher when subjects were primed with alcohol than with placebo-alcohol. Negative mood was also higher when it was assessed after the alcohol prime. Negative mood decreased in alcohol-primed subjects when the alcohol cue was available for consumption. The alcohol cue also had a significant, although more modest effect on craving. The alcohol cue consistently elicited higher levels of craving relative to the water cue. CONCLUSIONS: These data suggest that the priming effects of alcohol may be a significant factor contributing to the experience of craving and maintenance of drinking. The study also introduces the cue-availability as an additional new method for investigating manipulations of cue-reactivity in alcoholics.

Adult↗
PubMed1998

Effects of pre-cues on voluntary and reflexive saccade generation. I. Anti-cues for pro-saccades.

Experiments on visual attention have employed both physical cues and verbal instructions to enable subjects to allocate attention at a location that becomes relevant within a perceptual or motor task some time later (cue lead time, CLT). In this study we have used valid visual peripheral cues (CLT between 100 and 700 ms) to indicate the direction and location of the next saccade. A cue is considered valid or invalid if its meaning with respect to the next saccade is correct or incorrect. A cue is called an anti- or pro-cue if the side of its presentation is opposite to or the same as the direction of the saccade required on a given trial. Correspondingly, a saccade is called an anti- or pro-saccade if it is directed to the side opposite to or the same as the stimulus presentation. A condition in which the cue and the stimulus are presented on opposite sides provides a simple way of dissociating voluntary attention allocation from automatic orienting. This paper considers the anti-cue pro-saccade task: the subjects were instructed to use the cue to direct attention to the opposite side, i.e. the location, where on valid trials the saccade target would occur. In the companion paper we have used the same physical condition, but we have reversed the instructions as to saccade direction and we have reversed the meaning of the cue, i.e. we designed a pro-cue anti-saccade task. In this first paper, the saccadic reaction times (SRTs) of pro-saccades of five adult subjects were measured in the gap paradigm (fixation point offset precedes target onset by 200 ms). With a CLT of 100 ms, valid anti-cues reduced the number of express saccades (i.e. saccades with SRTs in the range 80-120 ms) significantly compared with the control values (no cues). Valid anti-cues with increasingly long CLTs (100-700 ms) resulted in an increasing incidence of anticipatory saccades and saccades with longer SRTs (more than 120 ms), while the frequency of express saccades remained below the control value. When cue and saccade target were dissociated in location or in both location and direction, the effects of the cueing revealed a much lower spatial selectivity as compared to the effects that have been described for voluntary attention allocation by means of central cues. The results suggest that voluntary allocation of attention and cue-induced automatic orienting not only have different time courses but also have opposite effects on the generation of express saccades, and different spatial selectivities. A possible neuronal basis of these results is discussed considering related findings from electrophysiological studies in monkeys.

Adult↗
PubMed2004

The basic laws of conditioning differ for elemental cues and cues trained in compound.

The cue-duration effect (i.e., longer cues result in less conditioned responding than shorter cues) was examined as a function of whether cues were trained alone or in compound. Compound (AX) or elemental (X) cues of either long or short duration were paired with the unconditioned stimulus. In testing with X alone, the cue-duration effect was observed with elementally trained cues, but not with compound cues. Instead, stronger responding resulted from training with long compound cues relative to short compound cues (i.e., a reversed cue-duration effect). Moreover, an overshadowing effect (i.e., decreased responding due to compound conditioning) was observed when conditioning was conducted with a short cue, but compound conditioning resulted in enhanced responding when it was conducted with a long cue (i.e., reversed overshadowing). These findings are consistent with other recent demonstrations that some laws of learning that apply to elementally trained cues do not similarly apply to cues trained in compound.

Animals↗
PubMed1997

The relationship between central cues and peripheral cues in covert visual orientation.

Four experiments were conducted to compare valid and invalid cue conditions for peripheral and central cues. Experiments 1, 3, and 4 used reaction time (RT) as the dependent variable. Experiment 2 used a threshold measure. Peripheral and central cues were presented on each trial. The peripheral cue was uninformative in all experiments. The central cue was informative in Experiments 1 and 2, where it predicted stimulus side on 70% of the trials. Experiment 3 included 50% and 100% central-cue prediction conditions as well as the 70% treatment. Experiment 4 included 60%, 75%, and 90% central-cue prediction conditions. The effects of the central and peripheral cues were independent and additive in all four experiments, indicating that: (1) both cue types can act simultaneously, and that the relationship between them is additive under the conditions used in these experiments, (2) informativeness is not a necessary condition for attentional effects with peripheral cues, and (3) covert visual orientation influences sensory thresholds and RT in similar ways. The results of Experiments 3 and 4 demonstrated that the facilitation associated with peripheral cues was insensitive to manipulations which demonstrate that subjects use the informational value of the central cue to direct voluntary attention. The results are discussed with reference to two issues; first, the proposition that central and peripheral cues exert their influence on performance in independent information-processing stages, following the additive factor method, and, second, the problems raised for additive factors method when cues elicit both an "explicit" response-regarding the presence or absence of a specified letter-and an "implicit response"-involving the planning and possible execution of eye and hand movements.

Adolescent↗
PubMed2001

Effect of different cue stimulus delivery channels on craving reactivity: comparing in vivo and video cues in regular cigarette smokers.

Exposure to smoking cues reliably produces increases in craving compared to exposure to appropriately matched neutral cues. While different types of stimuli have been used as cue materials in such studies, the channel through which cues are delivered is not often varied in a systematic fashion in smoking research. This study compared the effect of exposure to active in vivo cues compared to two cues, matched for content and time, delivered via videotape on self-reported smoking craving. Results revealed that active in vivo cues produced the highest Craving ratings. followed next by active video cues, and last by neutral video cues. These results suggest that craving is sensitive to stimulus delivery channel and that video presentation of smoking cues is a viable manipulation option in cue reactivity studies.

Adult↗
PubMed1998

Effects of pre-cues on voluntary and reflexive saccade generation. II. Pro-cues for anti-saccades.

The reaction times of saccades (SRT) to a suddenly presented visual stimulus (pro-saccade) can be decreased and a separate mode of express saccades can occur when a gap paradigm is used (i.e. fixation-point offset precedes target onset by 200 ms). A valid peripheral cue, presented briefly (100 ms) before target onset, has been found to facilitate the generation of saccades to the target, thereby increasing the frequency of express saccades and decreasing the mean latency. This facilitation occurs only for cues that correctly indicate the direction of the subsequent target presentation (valid cues). The present study investigates the effects of valid cues on SRTs and error rate in the anti-saccade task (saccades in the direction opposite to the stimulus) by systematically varying the cue lead time (CLT) and using the gap and overlap conditions, i.e. fixation point remains on throughout the trial. For a CLT of 100 ms, both reaction times and error rates were significantly increased. With increasing CLT (200-500 ms), both the reaction times of the anti-saccades and the error rates returned to approximately control level, with CLT more than 200 ms in both the gap and the overlap condition. Additional experiments using non-informative cues in the overlap task showed that the reaction times of correct anti-saccades and the error rate were decreased when cue and stimulus appeared at the same side. Analysis of the erratic pro-saccades revealed that almost all of them were corrected, i.e. they were followed by a second saccade towards the required location. It is found that the correction times were usually very short, with intersaccadic intervals between 0 and 150 ms. We suggest that the orienting mechanism, elicited by a transient peripheral cue, relates to the command and the decision to make a pro- rather than an anti-saccade. The cue elicits pro-orienting towards its position when a pro-saccade is required, and anti-orienting when an anti-saccade is required. The orienting effect is transient and decays with CLTs of more than 200 ms; this result holds for both anti-saccades and pro-saccades. Since subjects reported that they could not prevent the erratic pro-saccades or were often not aware of them, we conclude that this orienting mechanism occurs automatically, beyond voluntary control.

Adult↗
PubMed1990

The effects of grammatic class and cue type on cueing responsiveness in aphasia.

This study investigated the effects of two types of cues (semantic and phonemic) and two grammatic classes (noun and verb) on cueing responsiveness. Subjects consisted of 10 Broca's, 10 Wernicke's, 8 conduction, and 8 anomic aphasics. Cues were administered following failure to name on confrontation. Responsiveness to the two types of cues was dependent on aphasic type and grammatic class. Broca's and conduction aphasics responded better to phonemic cueing, while anomic aphasics were more responsive to semantic cueing. With regard to grammatic class, aphasics responded better to phonemic cueing on nouns; however, no significant difference between types of cues was demonstrated on verbs. Neuropsychological implications for the cueing and naming processes are discussed.

Aged↗
PubMed2004

Memory retrieval given two independent cues: cue selection or parallel access?

A basic but unresolved issue in the study of memory retrieval is whether multiple independent cues can be used concurrently (i.e., in parallel) to recall a single, common response. A number of empirical results, as well as potentially applicable theories, suggest that retrieval can proceed in parallel, though set forth a model that denies that possibility. In this paper, five quantitative models are developed to test broad candidate principles. In multiple experiments, subjects were trained to retrieve a vocal digit response for each member of a set of letter or color cues. In subsequent test and transfer phases, single cue trials were randomly mixed with dual cue trials on which the two cues always required the same response. For the first few repetitions of each new set of dual cue items, there was no evidence of parallel retrieval over any part of the RT distribution. After more repetitions, dual cue trials were performed faster than single cue trials, but only under conditions that were favorable to development of a "chunked" dual cue representation. These results indicate that associative independence is an important modulating variable that must be heeded in any general model of attention and memory retrieval. Further, the results are most consistent with a model that places the performance bottleneck prior to the retrieval stage of processing.

Choice Behavior↗
PubMedDate not supplied

Individual differences in cue reactivity among smokers trying to quit: effects of gender and cue type.

Across studies, when presented with a variety of smoking cues, smokers and ex-smokers evidence distinct patterns of self-reported, physiological, and behavioral reactions. However, few studies have compared more than two different kinds of cues within the same experiment. Furthermore, despite the importance of examining the moderating effect of gender on smoking outcomes, few studies have examined gender differences in smoking cue reactivity. We examined the effect of eight distinct cue manipulations on heart rate, mean arterial pressure, smoking urges, and self-efficacy in a sample of 129 participants (50% female) who had recently quit smoking. Cue manipulations included (a) in vivo exposure, (b) an idiographically designed exposure of subjects' most recent relapse, (c) an idiographically designed exposure to subjects' highest risk situation, and (d) affectively valenced standardized scripts depicting situations generally associated with relapse. These manipulations were compared to a standard cognitive stressor (mental arithmetic) and to a resting baseline. Results revealed differences in the degree of reactivity to different manipulations, with in vivo cues producing the greatest changes. Gender differences in reactivity between the type of cues presented were found for mean arterial pressure, with standardized scripts producing greater changes for women. These findings have implications for understanding the reasons for differences in cue reactivity across manipulations and for gender differences in cue reactivity.

Adult↗
PubMed2003

When cues collide: use of stress and statistical cues to word boundaries by 7- to 9-month-old infants.

Prior research suggests that stress cues are particularly important for English-hearing infants' detection of word boundaries. It is unclear, though, how infants learn to attend to stress as a cue to word segmentation. This series of experiments was designed to explore infants' attention to conflicting cues at different ages. Experiment 1 replicated previous findings: When stress and statistical cues indicated different word boundaries, 9-month-old infants used syllable stress as a cue to segmentation while ignoring statistical cues. However, in Experiment 2, 7-month-old infants attended more to statistical cues than to stress cues. These results raise the possibility that infants use their statistical learning abilities to locate words in speech and use those words to discover the regular pattern of stress cues in English. Infants at different ages may deploy different segmentation strategies as a function of their current linguistic experience.

Attention↗
PubMed2001

Illuminant cues in surface color perception: tests of three candidate cues.

Many recent computational models of surface color perception presuppose information about illumination in scenes. The models differ primarily in the physical process each makes use of as a cue to the illuminant. We evaluated whether the human visual system makes use of any of three of the following candidate illuminant cues: (1) specular highlight, (2) full surface specularity [Lee, H. C. (1986). Method for computing the scene-illuminant chromaticity from specular highlights. Journal of the Optical Society of America A, 3(10), 1694-1699; D'Zmura, M., & Lennie, P. (1986). Mechanisms of color constancy. Journal of the Optical Society of America A, 3(10), 1662-1672], and (3) uniform background. Observers viewed simulated scenes binocularly in a computer-controlled Wheatstone stereoscope. All simulated scenes contained a uniform background plane perpendicular to the observer's line of sight and a small number of specular, colored spheres resting on the uniform background. Scenes were rendered under either standard illuminant D65 or standard illuminant A. Observers adjusted the color of a small, simulated test patch to appear achromatic. In a series of experiments we perturbed the illuminant color signaled by each candidate cue and looked for an influence of the changed cue on achromatic settings. We found that the specular highlight cue had a significant influence, but that the influence was asymmetric: greater when the base illuminant, CIE standard Illuminant A, was perturbed in the direction of Illuminant D65 than vice versa. Neither the full surface specularity cue nor the background cue had any observable influence. The lack of influence of the background cue is likely due to the placement of the test patch in front of the background rather than, as is typical, embedded in the background.

Color Perception↗
PubMed2000

Auditory cues support place navigation in rats when associated with a visual cue.

Rats, like other crepuscular animals, have excellent auditory capacities and they discriminate well between different sounds [Heffner HE, Heffner RS, Hearing in two cricetid rodents: wood rats (Neotoma floridana) and grasshopper mouse (Onychomys leucogaster). J Comp Psychol 1985;99(3):275-88]. However, most experimental literature concerning spatial orientation almost exclusively emphasizes the use of visual landmarks [Cressant A, Muller RU, Poucet B. Failure of centrally placed objects to control the firing fields of hippocampal place cells. J Neurosci 1997;17(7):2531-42; and Goodridge JP, Taube JS. Preferential use of the landmark navigational system by head direction cells in rats. Behav Neurosci 1995;109(1):49-61]. To address the important issue of whether rats are able to achieve a place navigation task relative to auditory beacons, we designed a place learning task in the water maze. We controlled cue availability by conducting the experiment in total darkness. Three auditory cues did not allow place navigation whereas three visual cues in the same positions did support place navigation. One auditory beacon directly associated with the goal location did not support taxon navigation (a beacon strategy allowing the animal to find the goal just by swimming toward the cue). Replacing the auditory beacons by one single visual beacon did support taxon navigation. A multimodal configuration of two auditory cues and one visual cue allowed correct place navigation. The deletion of the two auditory or of the one visual cue did disrupt the spatial performance. Thus rats can combine information from different sensory modalities to achieve a place navigation task. In particular, auditory cues support place navigation when associated with a visual one.

Animals↗
PubMed2004

Inactivation of dorsolateral striatum impairs acquisition of response learning in cue-deficient, but not cue-available, conditions.

Rats received bilateral injections of lidocaine or artificial cerebrospinal fluid (aCSF) into the doisolateral striatum 6 min prior to training in either a plus- or T-shaped maze under cue-poor or cue-available conditions. Lidocaine injections significantly impaired acquisition in the cue-poor environments, but not in the cue-available environments. In addition, aCSF control rats trained in a plus-maze in a cue-poor environment reached criterion much more rapidly than did rats trained in a cue-available environment. These findings suggest that cue availability can permit acquisition of response learning in a manner that is not dependent on activity of the striatum. However, in a cue-poor environment, alternate strategies may be less readily available, revealing more efficient striatal involvement in response learning.

Anesthetics, Local↗
PubMed2000

Cue exposure in alcohol dependent patients: preliminary evidence for different types of cue reactivity.

Craving is considered to be an important phenomenon in addictive behaviours. However, there is still an unresolved debate on what craving for alcohol means, how it is best measured and which clinical and therapeutical consequences its presence or absence may imply. Cue reactivity paradigms have been developed to elicit craving under standardized experimental conditions. Here we present preliminary results characterizing alcohol-dependent patients with regard to subjective and psychophysiological aspects of exposure to alcohol-associated cues in a cue reactivity paradigm. Thirty-six patients fulfilling at least 5 criteria of alcohol dependence according to DSM-IV criteria were studied after detoxification. Cue reactivity was assessed as subjective (by visual analogue scales) and neurophysiological response (by ECG, EMG, electrodermal activity, respiratory frequency, salivation) to the presentation of the favourite alcoholic beverage or water. While 22% of the patients were both subjective and physiological responders, 42% of the subjects showed only a physiological reaction without subjective response, and 31% of the patients were neither a subjective nor a physiological reaction. Subjective responders to alcohol cues had significantly higher state anxiety levels than subjective non-responders. These results suggest that alcohol dependent patients may be divided into typological subgroups with respect to cue reactivity. Different types of cue reactivity might be important for treatment strategies involving repeated cue exposure or so-called anti-craving drugs.

Adult↗
PubMed2000

Appetitve effects of drug cues modelled by pictures of the intake ritual: generality of cue-modulated startle examined with inpatient alcoholics.

RATIONALE: A cue-modulated startle test recently confirmed that smoking cues in smokers may not be withdrawal-like and aversive as traditionally believed. OBJECTIVE: Analogous tests were applied to alcohol cues in inpatient alcoholics. METHODS: Twenty-six withdrawn alcoholics (18 men) were examined. Alcohol-related pictures were compared to standardised pleasant, neutral or unpleasant control scenes using an acoustic startle test and measures of pleasure, arousal and desire for alcohol. RESULTS: Pictures depicting preparation for drinking (cues) were different from unpleasant control pictures and similar to pleasant pictures but only on the startle test; no differential effects were found for alcohol craving and mixed motivational effects were reported subjectively. The effects were not due to arousal and control pictures depicting post-drinking events showed less effect than the alcohol cues. CONCLUSIONS: New techniques of measuring drug cue motivation indicate that drug cues may have incentive properties in individuals in treatment for alcoholism.

Adult↗
PubMed1999

The effects of alcohol cues and an alcohol priming dose on a multi-factorial measure of subjective cue reactivity in social drinkers.

RATIONALE: Exploring subjective alcohol cue reactivity in non-clinical samples should assist understanding in clinical samples where additional problems muddy the water. However, exploration is stalled through using insensitive, single-item representations. OBJECTIVE: The effect of alcohol cues and a priming dose of alcohol on a new multi-factorial representation of cue reactivity is sought (DAQ, Desire for Alcohol Questionnaire). METHODS: Prime and Cue exposure are variables in a standard 2x2 between subjects design set within a stooge taste-evaluation experiment. The DAQ was administered after a Prime and Cue exposure phase. RESULTS: Main effects for Cue exposure but not Prime were found for the DAQ total and the subscales Mild desires (positively reinforcing items) and Strong desires/intentions but not Negative reinforcement (negatively reinforcing items) and Controllability; however, there was no interaction. CONCLUSION: The DAQ is a sensitive measure of subjective cue reactivity in social drinkers and its potential in the evaluation of pharmacological interventions is proposed.

Adult↗