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Results for “CRUSH SYNDROME”

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At least 19 recordsLinked to original sources
PubMed2006

[New study on the history of anesthesiology--(12). A biography of Seigo Minami, the first to describe crush syndrome].

Crush syndrome causes a social concern as we experienced in the devastating earthquake in Kobe area in 1995. In the laboratory of Prof. Pick of Berlin, Seigo Minami (1893-1975), a dermatologist, made a detailed microscopic study of the kidneys of three German soldiers in 1922. They had died from renal failure caused by traumatic injuries during the World War 1. Minami concluded that the common cause of their deaths was "Autointoxication" due to necrotic breakdown of damaged muscles. His paper appeared in Virchows Archiv in 1923. This is the first description of crush syndrome in the world. Thereafter Minami joined the members of Prof. Warburg, Kaiser-Wilhelm Institute to investigate respiration and glycolysis of cancer tissues of rats. This research made an important contribution to the works of Prof. Warburg to whom a Nobel prize for medicine and physiology was awarded in 1931. Minami's name as the first describer of crush syndrome remains quite unknown in Japan, although almost all Japanese dermatologists know him by Minami Prize of Japanese Society of Dermatology.

Crush Syndrome↗
PubMedDate not supplied

Crush injury and crush syndrome.

Crush injury is caused by continuous prolonged pressure on the limbs. It is found in patients extricated after being trapped for at least 4 hours. The main injury is to the muscles of the limbs. Treatment should be conservative and fasciotomy should be avoided. If fasciotomy is performed, it should be followed by radical debridement of the injured muscle in an attempt to avoid infection of the injured limb. Infection endangers the patient's life and is the main cause of morbidity and mortality today. The outcome of conservative local treatment of crush injury is much superior to that of operative treatment. The pathophysiology of crush injury is not fully understood and no good animal model is known. Crush syndrome, which is the general manifestation of crush injury, is better understood. If not prevented, it will lead to acute renal failure. A method for preventing acute renal failure is discussed and a protocol is described. There is no doubt that prevention of acute renal failure is the goal in the treatment of crush syndrome and can be achieved.

Acute Kidney Injury↗
PubMed2004

Consensus statement on crush injury and crush syndrome.

Crush syndrome remains rare in European practice. It is, however, common in areas of civil disorder and where the normal structures of society have given way to civil war or natural disaster. Western doctors are becoming increasingly involved in such situations and there is no reason to believe that instances due to more conventional causes, such as collapse in the elderly or road traffic accidents will cease. For all these reasons it is important that clinicians who deal infrequently with crush syndrome have access to appropriate guidelines. This consensus report seeks to provide such advice.

Adult↗
PubMed2003

Consensus statement on the early management of crush injury and prevention of crush syndrome.

Crush Syndrome remains rare in European practice. It is however common in areas of civil disorder and where the normal structures of society have given way to civil war or natural disaster. Western Doctors are becoming increasingly involved in such situations and there is no reason to believe that instances due to more conventional causes, such as collapse in the elderly or road traffic accidents will cease. For all these reasons it is important that clinicians who deal infrequently with crush syndrome have access to appropriate guidelines. This consensus report seeks to provide such advice.

Crush Syndrome↗
PubMed1994

Early management and physiologic changes in crush syndrome.

Crush syndrome is a predictable sequence of events following crush injury. Significant soft tissue injury predisposes the patient to multiple complications including: hypovolemia, compartment syndrome, rhabdomyolysis, electrolyte and acidbase imbalances, coagulopathy, and renal failure. This article identifies those physiologic changes and the associated critical care management of the patient. Critical care management should be aimed at minimizing further complications through accurate assessment and therapeutic interventions.

Compartment Syndromes↗
PubMed2005

[Clinical study of cervical myeloradiculopathy with carpal tunnel syndrome, double crush syndrome].

The hypothesis, "double crush syndrome (DCS)", is that neural function could be impaired when single axons, having been compressed in one region, become especially susceptible to damage in another. We retrospectively review our surgical cases with both cervical lesion and carpal tunnel syndrome, i.e., DCS. From January 2001 to January 2005, we have treated 7 patients (Male-4, Female-3, average age-59.9 years old) under the diagnosis of DCS. Cervical lesions were cervical spondylosis in 4 and cervical narrow canal in 3 patients. Peripheral entrapment neuropathy was carpal tunnel syndrome in all 7 cases. Initial operation was performed for cervical lesion in 2, carpal tunnel syndrome in 2, and 3 cases were operated simultaneously. The improvement rate by Neurosurgical Cervical Spine Scale (NCSS) was average 65.8%. The average follow-up period was 18.2 months. Good results can be obtained in 5 cases, and poor results in 2 cases who underwent initial operation under the diagnosis of single lesion. It is well known that a discrepancy between neurological manifestation and neuro-imaging sometimes occurs in cervical lesions, and then DCS should be considered as a possible pathogenetic mechanism.

Adult↗
PubMedDate not supplied

[Pathology of crush syndrome].

Clinico-anatomical analysis of surgical material (32 cases) and 86 autopsy cases of myorenal syndrome (crush syndrome) is presented. Clinically in all cases there were symptoms of acute renal (hepatico-renal) failure which was a cause of death during the first 2 weeks. Septic complications were a cause of death at later periods. Grave alterations of traumatic, metabolic and septic origin were found in many organs in all cases. The sources of sepsis were decompressing longitudinal cuts and fasciotomies, shunts, lacerated wounds, catheters. Combined local treatment of wounds with sorbents, antibiotics, proteolytic enzymes, quantum therapy facilitated the destruction of bacteria and loss of their activity, wound purification and thus allowed coping with septic complications.

Acute Kidney Injury↗
PubMed1991

The role of reperfusion-induced injury in the pathogenesis of the crush syndrome.

The crush syndrome consists of the general manifestations that follow prolonged continuous pressure on the limbs. These manifestations are caused by the disintegration of muscle tissue and leakage of the contents of myocytes into the plasma. The morbidity and mortality associated with this syndrome are high. The pathophysiologic process of the derangements associated with the crush syndrome is not fully understood, but the injury induced by reperfusion is likely to be important in its development. The injury due to reperfusion involves many factors, but it is currently ascribed largely to the release of oxygen free radicals, massive accumulation of calcium in ischemic muscles, and the infiltration of neutrophils into reperfused vessels. Since ischemic muscles cannot survive without reperfusion, a strategy to salvage as much of the muscle and kidney tissue as possible in the crush syndrome must include ways of decreasing injury during ischemia and reperfusion. Various pharmacologic agents may attenuate or prevent reperfusion-induced injury to ischemic skeletal muscles and consequently to other organs, particularly the kidneys.

Calcium↗
PubMed1995

[Endotoxemia in crush syndrome].

The crush syndrome developing in casualties in mass catastrophes is the cause of their high mortality rates. We examined 18 children aged from 9 to 14 years with the crush syndrome who suffered during the earthquake in Armenia. Besides other laboratory studies, the test for the titer of antibodies (TA) to endotoxin was performed. Despite the applied complex therapy, the children's condition grew worse on day 8. The TA level reduced threefold. Six patients received a single infusion of plasma with naturally increased TA titer in a dose of 10 ml/kg. On the following day after TA infusion, the condition of children in the experimental group improved, the clinical picture of endotoxemia in the control group persisted for 10-12 days.

Adolescent↗
PubMed1978

Crush syndrome.

The crush syndrome has been an accompaniment of crushing injuries following disaster situations. Recognition of the sequence of events and early institution of the appropriate therapy is essential, if life is to be saved in these critically injured persons. Treatment should be begun 'on site' and arrangement then made for transport to a major medical facility as rapidly as feasible.

Acidosis↗
PubMed1990

The role of thoracic outlet syndrome in the double crush syndrome.

The association between thoracic outlet syndrome (TOS) and carpal tunnel syndrome (CTS) (40 cases), ulnar neuropathy (UN) (19 cases) and radial tunnel syndrome (29 cases) is investigated. The possibility of a double crush syndrome is considered with reference to the difficulties in diagnosis. It is demonstrated that in approximately half of all cases the proximal neuropathy precedes the distal one. Despite the fact that surgical treatment of the thoracic outlet syndrome appears to improve the distal neuropathy it is still difficult to decide, in a given case, which decompression takes priority with the exception of carpal tunnel release which is generally to be performed first. The historical background and theoretical basis of the management of double crush syndrome is outlined and arguments for and against the association of the various neuropathies are presented.

Adult↗
PubMedDate not supplied

Compartmental syndrome and its relation to the crush syndrome: A spectrum of disease. A review of 11 cases of prolonged limb compression.

A review of 11 cases of prolonged limb compression usually following drug overdose, revealed a spectrum of disease from isolated compartmental syndromes to full crush syndromes with renal failure. Residual limb contractures were moderate or severe in 80 per cent of the extremities involved. Five of the 11 patients demonstrated significant, systematic manifestations, Stage II or Stage III crush syndrome by our definition. The severity of the systemic manifestations is related to the amount of muscle tissue being subjected to elevated pressure and the length of time this pressure is maintained. Delay in hospitalization, delay in diagnosis, and delay in treatment prolong this period. The diagnosis should be made on the basis of the histroy of prolonged immobilization and the finding of a swollen extremity. Fasciotomy should be performed immediately, both to minimize residual limb contracture and to prevent the crush syndrome from developing secondary to myonecrosis.

Acute Kidney Injury↗
PubMed2002

Increased plasma nitrate levels in patients with crush syndrome in the Marmara earthquake.

BACKGROUND: Crush syndrome has been described as extensive muscle damage, leading to acute renal failure. The aim of this study was to evaluate the possible role of nitric oxide, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) in crush syndrome. PATIENTS AND METHODS: A total of 17 patients suffering from crush syndrome, 7 patients without crush syndrome and 10 healthy controls were enrolled in the study. Plasma nitrate, TNF-alpha, IL-1 beta levels and biochemical parameters were measured. RESULTS: All patients with crush syndrome demonstrated acute renal failure. Plasma nitrate levels were elevated significantly in the crush syndrome patients compared with patients without crush syndrome (33.5 +/- 20.1 vs. 15.3 +/- 5 micromol/l, p=0.014). There was no significant difference in TNF-alpha and IL-1 beta levels between control and patient groups. CONCLUSION: Increased plasma nitrate levels in the crush syndrome may be related either to the elevated production of NO or the diminished excretion of nitrate or both.

Adolescent↗
PubMed2003

Crush injury and crush syndrome: a consensus statement.

Crush syndrome remains rare in European practice but is common in areas of civil disorder and where society has given way to civil war or natural disaster. Clinicians in the west are becoming increasingly involved in such situations and there is no reason to believe that the few instances due to conventional causes, such as an elderly person collapsing or road traffic accidents, will cease. Therefore, it is important that clinicians who deal rarely with crush syndrome have access to appropriate guidelines. This consensus report seeks to provide such advice.

Adult↗
PubMedDate not supplied

Crush syndrome: pathophysiology and management.

Crush syndrome is characterized by a predictable sequence of events that include hypovolemia, compartment syndrome, rhabdomyolysis and acute tubular necrosis (ATN). Cardiac dysrhythmias are common. Pathophysiology, current management, and a plan of nursing care for patients with crush syndrome are presented.

Crush Syndrome↗