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Results for “CHORIOADENOMA”

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At least 19 recordsLinked to original sources
PubMed1967

Ultrastructure of molar trophoblast. Observations on hydatidiform mole and chorioadenoma destruens.

The ultrastructure of molar trophoblast is described in hydatidiform mole and chorioadenoma destruens. Villous molar trophoblast exhibits only minor deviations from normal early villous trophoblast. Invasive trophoblast of chorioadenoma destruens shows features of more-active cell growth, multiplication, differentiation, and degradation. Evidence for evolution of highly differentiated syncytial trophoblast via intermediate stages from primitive undifferentiated cytotrophoblast is confirmed. Cytoplasmic inclusions resembling virus-like particles, observed in chorioadenoma destruens, have not been hitherto described in normal or pathologic trophoblast.

Chorionic Villi↗
PubMed1981

Dissociation of chorioadenoma destruens from hydatidiform mole by urinary steroid analysis.

Dissociation between hydatidiform mole (HM) and chorioadenoma destruens (CA) was attempted by gas chromatographic analysis of urinary steroids. In the chromatogram, fraction 2 (F2) including four pregnane steroids (17-hydroxypregnanolone, pregnanolone, pregnanediol, and pregnanetriol) reflected the biologic activity of molar human chorionic gonadotropin (hCG), and the ratio of F2 to fraction 1 (F1) (17-ketosteroids) was found useful in monitoring secondary growth of trophoblastic tumor: Urinary log F2/F1 after curettage declined quickly and unidirectionally in HM, but the same parameter exhibited a temporal rise in CA at 11 to 20 days after curettage because of the molar hCG from residual tumor tissue. The resolution between HM and CA at that stage (11 to 20 curettage days) was of the order of diagnostic use and superior to that with immunoreacive hCG. The data obtained are discussed in the light of pathophysiology of CA.

17-Ketosteroids↗
PubMed1989

[Chorioadenoma destruens: presentation of 2 cases].

The incidence of Gestational Trophoblastic Disease varies from country to country, however, it is notable the greater frequency for developing nations. The incidence in Mexico varies from one in 144 to 625 pregnancies. The advances that have been made in the knowledge of this disease and its classification allow an integrated diagnosis and management of gestational trophoblastic disease. This report presents two cases of Chorioadenoma Destruens in which myometrial invasion was suspected from ultrasonographic studies. One case was treated with chemotherapy; the other by histerectomy following uterine perforation. The outcome was satisfactory in both cases.

Adult↗