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At least 19 recordsLinked to original sources
PubMed2026

Glycemic and safety outcomes of the insulin-only bionic pancreas in older adults and individuals with impaired awareness of Hypoglycemia: a post hoc analysis of a randomized pivotal trial.

AIMS: Evaluate the efficacy and safety of iLet Bionic Pancreas (BP) in older adults and individuals with impaired awareness of hypoglycemia (IAH). METHODS: This post hoc analysis used individual participant-level data from the Insulin-Only Bionic Pancreas Pivotal Trial (n = 440; NCT04200313). Eligible participants (n = 96) with type 1 diabetes, aged ≥ 60 years and/or had IAH (Clarke score ≥ 4), were randomized to BP with aspart/lispro (BP-Asp/Lis; n = 45), BP with fast-acting aspart configuration (BP-Fiasp; n = 31), or standard care (SC; n = 20) for 13 weeks. RESULTS: Compared with SC, time-in-range (70-180 mg/dL) significantly increased by 7.49 % (95 % CI: 2.61 to 12.38; ∼1.8 h/day) with BP-Asp/Lis and by 8.28 % (95 % CI: 3.15 to 13.41; ∼2.0 h/day) with BP-Fiasp, driven by reduced hyperglycemia. No significant differences were observed in hypoglycemia exposure. Severe hypoglycemia occurred in four participants (four events) on BP-Asp/Lis and one participant (two events) on SC. One diabetic ketoacidosis event occurred on BP-Fiasp due to an infusion set failure. CONCLUSIONS: In high-risk, clinically vulnerable populations, the BP system significantly improved glycemic control while maintaining safety parity with respect to hypoglycemia risk, providing a resilient therapeutic alternative for vulnerable cohorts.

Humans↗
PubMed1991

Evaluation of the Bionic trap to quickly kill mink (Mustela vison) in simulated natural environments.

The Bionic trap, with a bait placed at the back of a 6 cm aperture plastic cone, successfully killed nine of nine wild mink (Mustela vison) in simulated natural conditions. The average times to loss of consciousness and heartbeat were estimated at less than 60 (+/- 26) sec and 340 (+/- 55) sec, respectively, after firing the trap. This study confirmed that the Bionic trap can be expected to render greater than 79% of captured mink unconscious in less than or equal to 3 min (P less than 0.05).

Animal Welfare↗
PubMed1990

[Bionics: limits and perspectives].

Bionics, based on analogies between living beings and technical systems, neglect fundamental differences, e.g., on the one hand, technology uses high temperatures, a mean closed to all living beings and, on the other hand, the cells of all organisms keep high autonomy. The first fact makes it possible, e.g., to construct airplanes three or four powers of ten heavier than the heaviest birds, whereas the second fact enables each cell to reproduce itself, to restore lost limbs or even the whole organism, far beyond the reach of technology. The symbiosis of organisms and technical installations (biotechnology) or, on a higher level, of mankind and environment, may be a guiding star for future development.

Animals↗
PubMed1991

Bionic organs.

When a lizard loses its tail, a new caudal appendage soon grows to replace the one that is missing. But when a human loses a kidney, severs a peripheral nerve or worse, the spinal cord, that organ is lost forever. Such at least is conventional thinking. But imagine that the victim of an industrial accident with a paralyzed hand could achieve new levels of function by inducing axonal regrowth through a synthetic nerve guidance channel; or that a Parkinsonian patient's symptoms could be relieved by implanting in his brain neural tissue encased in a selectively permeable polymer envelope; or that the inexorable progression of the vascular complications of juvenile diabetes could be stopped, even reversed, by a membrane-protected xenograft of insulin-producing tissue. This is the dream of bionic organ science. It is predicated on two lines of technological achievement: the availability of ultra-thin, biocompatible, selectively permeable polymer membranes which can protect a transplant against immune rejection while allowing solute exchange between the graft and its environment; and the synthesis of novel materials, some biostable, some bioresorbable, which can serve as scaffolding or anchor for tissue regrowth in the geometrically and chemically controlled environment of an implant. The fabrication, growth and survival of composites of living tissues with synthetic polymers, often enhanced by the incorporation of specific cell growth factors or inhibitors, has been demonstrated at the tissue culture level, and extended in vivo to experimental models of human endocrine deficiency or neurological defects. The key to progress with bioartificial organs is the confluence of knowledge ranging from materials science to cell and molecular biology to experimental surgery. Obstacles to clinical implementation of this new therapeutic concept include: large scale procurement of specific tissue structures or isolated postmitotic cells from animal sources; demonstration of safety and efficacy of spontaneously occurring, bioactive tumor cell lines; verification of long-term stability and bio-acceptance of polymer implants; and industrialization of the fabrication process to meet quality control, shelf-life and commercial distribution requirements.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMedDate not supplied

[Design aspects and hydrodynamic characteristics of the Bionics heart valves].

It has been shown that Bionics prostheses compare very favorably with bioprostheses based on rigid supporting frameworks. The advantages of the above prostheses lie in the fact that the supporting frameworks of changed stiffness used in their modelling possess damping capacities at minute physical loadings, which considerably improves the hydrodynamic characteristics of biovalves.

Animals↗
PubMed2026

Genetics of major depressive disorder in a homogeneous population with uniform phenotyping.

Harmonized phenotyping and diverse population-specific studies are crucial for advancing gene discovery in psychiatric genetics. We conducted a genome-wide association (GWAS) mega-analysis of DSM-defined lifetime major depressive disorder (MDD) in 64 941 participants (25.7% cases) from the Dutch BIObanks Netherlands Internet Collaboration (BIONIC) consortium. Liability-scale SNP-based heritability was 12.0% (SE = 1.4%) as estimated by LDSC (assuming a lifetime prevalence of 15%) and 26.6% (SE = 1.1%) when estimated by LDAK-REML on individual-level genotype data, indicating substantial common-variant signal in this clinically harmonized sample. The genetic correlation with the latest major depression GWAS from the Psychiatric Genomics Consortium (PGC-MD) was high (rG = 0.89, SE = 0.048). Polygenic scores (PGSs) based on BIONIC predicted depression in UK Biobank, and PGSs derived from PGC-MD predicted MDD in BIONIC, supporting transferability of depression polygenic signal across cohorts and phenotype definitions. Within-family PGS analyses in twins suggested that the observed prediction was not primarily driven by detectable family-level confounding, and twin concordance for MDD increased with polygenic burden. We identified one genome-wide significant locus, indexed by rs3818852 in PALMD, but this finding currently lacks independent replication and should be interpreted cautiously. Finally, genetic correlation and latent causal variable analyses identified multiple traits showing shared or directionally consistent genetic associations with MDD. Together, these findings underscore the value of clinically harmonized phenotyping in regional biobank collaborations for studying the genetic architecture of MDD.

Humans↗
PubMed1989

Models of human memory.

The capacity to store and retrieve information is a property common to biological organisms and certain artefacts. Psychological models of human memory fall into two rival classes: a) "bionic" models which draw inspiration from the structural and functional properties of the central nervous system (computo bionic models); b) "symbolic information processing" models in which the inspiration for description and explanation of natural processes is drawn from the structural and functional properties of Von Neumann computers (computo-symbolic models).

Humans↗
PubMed1977

Future of home hemodialysis.

An attempt to prophesy the future of home hemodialysis is based on anticipated near and long term technological improvements. Dialysis treatments will become shorter, due to pressure filtration, while extracting molecules in the 300 to 3000 dalton weight range through more permeable membranes. Portable and wearable dialysis systems will increase patient mobility. By the 21st century, implantable bionic kidneys and perfect host tolerance to renal allografts and xenografts will relegate home hemodialysis to history texts. A non-surgical definitive treatment for uremia is envisioned in the colonization of the human bowel with nitrogenn recycling bacteria.

Bionics↗
PubMed1992

cAMP activation of CF-affected Cl- conductance in both cell membranes of an absorptive epithelium.

Cystic fibrosis (CF) is characterized by abnormal epithelial Cl- conductance (GCl). In vitro studies that have shown that cAMP regulation is an intrinsic property of the CF-affected GCl(CF-GCl) have been carried out previously on cultured secretory cells and on nonepithelial cells. Even though GCl in absorption is defective in CF, a clear demonstration of cAMP regulation of CF-GCl in a purely absorptive tissue is lacking. We studied the cAMP regulation of CF-GCl in the microperfused intact human reabsorptive sweat duct. About 40% of the ducts responded to cAMP (responsive) while the remainder of the ducts did not. In responsive ducts, cAMP-elevating agents: beta-adrenergic agonist isoproterenol (IPR), CPT-cAMP, forskolin, theophylline or IBMX increased Gt by about 2.3-fold (n = no. of ducts = 8). Removal of media Cl-, but not amiloride pretreatment (in the lumen), abolished the cAMP response, indicating exclusive activation of GCl. cAMP activated both apical and basolateral GCl. cAMP hyperpolarized gluconate: Cl- (lumen:bath) transepithelial bionic potentials (delta Vt = -20.3 +/- 5.2 mV, mean +/- SE, n = 9) and transepithelial 3: 1 luminal NaCl dilution diffusion potentials (delta Vt = -8.8 +/- 2.9 mV, n = 5). cAMP activated basolateral GCl as indicated by increased bi-ionic (gluconate:Cl-, bath:lumen) diffusion potentials (by about 12 mV). The voltage divider ratio in symmetric NaCl solutions increased by 60%. Compared to responsive ducts, nonresponsive ducts were characterized by smaller spontaneous transepithelial potentials in symmetrical Ringer's solution (Vt = -6.9 +/- 0.8 mV, n = 24, nonresponsive vs. -19.4 +/- 1.8 mV, n = 22, responsive ducts) but larger bi-ionic potentials (-94 +/- 6 mV, n = 35, nonresponsive vs. -65 +/- 5 mV, n = 17, responsive ducts) and dilution diffusion potentials (-40 +/- 5 mV, n = 11, nonresponsive vs. -29 +/- 3 mV, n = 7, responsive ducts). These results are consistent with an inherently (prestimulus) maximal activation of GCl in nonresponsive ducts and submaximal activation of GCl in responsive ducts. We conclude that cAMP activates CF-GCl which is expressed and abnormal in both apical and basal membranes of this absorptive epithelium in CF.

Adrenergic beta-Agonists↗
PubMed1989

New cardiac bioprostheses: theory, experiments, and 10 years of clinical use.

The biological valve "BAKS" has the following specific features: (1) it is practically devoid of immunogenicity due to fermentative-chemical treatment; (2) it is completely treated with glutaraldehyde through gradual soaking in solutions of increasing concentration; (3) the biological part is fashioned taking into account the biomechanics of the aortic root; (4) the polypropylene stent is functional due to the use of the principles of bionics in valve construction; and (5) practically no thromboemboli occur, because of the special morphologic organization of the cuff and the distant location of the bioprosthesis leaflets from the stent edge. In the Department of Heart Surgery of the National Research Center of Surgery, "BAKS" valves have been used in 237 patients undergoing isolated mitral valve replacement for rheumatic heart disease. Of these 35% were younger than 35 years, 93.7% belonged to New York Heart Association functional class IV, and 24% had had a previous heart operation. The 10-year survival rate without hospital mortality was 68.94% +/- 4.86%. Total follow-up was 11,232 patient-months (range; 6 to 118 months; mean, 57 months; 97% complete). Main causes of death and reoperation were (per patient-year) infectious endocarditis, 3.2%; spontaneous bioprosthesis degeneration, 0.96%; mechanical dysfunction resulting from damage in the manufacturing of the prosthesis, 0.74%; left atrial thrombosis and/or thromboemboli, 0.5%; sudden death, 0.2%; cardiac insufficiency, 0.3%; and other, 0.4%.

Bioprosthesis↗
PubMed1992

Total eye transplantation for the blind: a challenge for the future.

Blindness is a human and social problem of incalculable weight. In the future, artificial 'bionic' prostheses and retinal grafts could achieve a long-sought cure. Several lines of evidence led to the speculation that a total eye transplantation for the cure of retinal blindness may become feasible in the near future. It is proposed that a brain dead patient's eye, whose retinal viability has been demonstrated with an electroretinogram recording, be transplanted into the blind's voided orbital socket, through a frontoorbitotemporal craniotomy and orbitozygomatic osteotomy. Regenerating optic nerve axons are channeled in a specially constructed guide to the homolateral corpus genicolatum laterale, while the retinal ganglion cells are adequately protected during the regrowth period. Aspects of this paradigm are reviewed and discussed.

Animals↗