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Results for “BRONCHIAL SPASM”

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At least 19 recordsLinked to original sources
PubMed1977

[Bronchial spasm and bronchial motoricity].

The author recalls the phenomena which control bronchomotility, without a personal study but based on recent bibliography. After recalling the bronchial nerve supply, the chemical intermediates, the various responses of the bronchial tree to autacoids, the author recalls the association of anesthesia and bronchospasm. Although the bronchial reactions of histaminic origin are the most frequent, mechanical or chemical irritation is recalled with an elementary description of "irritant receptors" and stretch receptors. Finally, the other causes of bronchial narrowing are considered: vago-sympathetic imbalance, atopic background, influence of the anesthetic on vagal tone or on adrenal medullary secretion.

Anesthesia, General↗
PubMed1997

[Study of spontaneous resolution of bronchial spasm after methacholine challenge. Comparison of patients with different degree of hyperreactivity].

The study was designed to assess the spontaneous recovery of bronchial spasm induced by methacholine in bronchial challenge tests and to examine the mechanisms and the modalities involved as well as the influence of dosage. The phenomenon was analysed in 32 hyperreactive patients diagnosed as asthmatics by measuring FEV1 as soon as maximum bronchial constriction (PD20) had been achieved and after 5, 10, 15, 30 and 60 minutes. The data obtained were subjected to variance analysis. Results show: 1) as regards duration of spontaneous recovery, that FEV1 returned to pre-challenge levels after 60 minutes in both the severely and moderately hyperreactive patients; 2) as regards onset of regression, that onset depended on the level of sensitivity, occurring after 30 minutes in the severely affected, after 15 minutes in the mild cases; 3) as regards recovery intensity, that in the moderated cases the recovery was more pronounced in the first 15 minutes than subsequently. Data show that the onset and intensity of the spontaneous recovery change according to the degree of sensitivity. That might reflect a greater affinity and/or bonding of methacholine in the muscarinic receptors of the severely affected, but the possibility of a difference in mediator metabolization speed cannot be excluded. In conclusion, research into the recovery of bronchial spasm may contribute to a better understanding of bronchial hypersensitivity and provide new information of value on the diagnosis, pathogenesis and treatment of the condition.

Adult↗
PubMed1976

[The effect of (8r)-3alpha-hydroxy-8-isopropyl-1alphaH,5alphaH-tropaniumbromide-(+/-)-tropate ((ipratropiumbromide) on tracheobronchial spasm, bronchial and salivary secretions, ECG and heart rate (author's transl)].

At very low doses (8r)-3alpha-hydroxy-8-isopropyl-1alphaH,5alphaH-tropaniumbromide-(+/-)-tropate (ipratropiumbromide, Sch 1000, Atrovent) and atropine inhibit acetylcholine-induced bronchospasms in guinea-pigs and dogs. The dose ratio main effect vs. most sensitive side effect (inhibition of saliva secretion) is 1:10 for i.v. injection and 1:100 for aerosol application. When both compounds are administered in a nebulized form bronchodilatation occurs immediately. The maximum effect of Sch 1000 occurs somewhat later than that of atropine but the duration of action is much longer. Bronchial secretion in guinea-pigs is increased by small doses of Sch 1000 and atropine. These doses correspond to bronchodilating doses.

Acetylcholine↗
PubMed1980

D-penicillamine-induced bronchial spasm.

Although d-penicillamine has a wide range of benefits in many clinical conditions, various side effects have also been reported and preclude its further use in certain patients. In this case, d-penicillamine-induced reversible airway obstruction developed, despite the "go slow--go low" regimen as suggested to reduce the incidence of its side effects. The patient had bronchial spasm and angioedema shortly after the dose was increased from 500 mg to 750 mg/day. Persistent vigilance is necessary to avoid potentially fatal reactions.

Adolescent↗