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IBEES Prize Lecture. The future of biomedical engineering.

Biomedical engineering is recognized as having developed an identity distinct from traditional engineering disciplines. The concepts which characterize this identity are outlined. The consequences of these are considered with particular attention to changing attitudes to professional specialization and work within the clinical environment.

Awards and Prizes↗

Application of knowledge information processing methods to biochemical engineering, biomedical and bioinformatics fields.

In biochemical and biomedical engineering fields there are a variety of phenomena with many complex chemical reactions, in which many genes and proteins affect transcription or enzyme activity of others. It is difficult to analyze and estimate many of these phenomena using conventional mathematical models. Recently some knowledge information processing methods, such as the artificial neural network (ANN), fuzzy reasoning, fuzzy neural network (FNN), fuzzy adaptive resonance theory (fuzzy ART) and the genetics algorithm (GA), were developed in the computer science field and have been applied to analysis in a variety of research fields. In this chapter, these methods will be briefly reviewed. Next, the application of these methods in the biochemical field will be introduced, instancing two examples in actual industrial processes. In addition, the application in the biomedical and bioinformatics field as another attractive field will be reviewed. Two examples are our research such as the prediction of prognosis for cancer patients from DNA microarray data using FNN and gene clustering for DNA microarray data using fuzzy ART.

Artificial Intelligence↗

Application of biomedical engineering to neurosurgery.

Biomedical engineering is increasingly becoming very important also in neurosurgery. This article describes some examples of neurosurgical applications of biomaterials which play a central role in biomedical engineering. Since a large number of biomaterials are currently used in neurosurgery, only the biomaterials that have been developed in our laboratories in collaboration with neurosurgeons are briefly presented here. The biomaterials developed include devices used for interventional neurosurgery and bioabsorbable scaffolds for regeneration of dura mater and skull bone. We developed an immediately electrically detachable coil using a poly(vinyl alcohol) junction between the coil and the delivery wire. This is the first detachable coil developed in Japan and is currently under clinical trial. In addition to the coil used for interventional neurosurgery, the development of an embolic liquid is presented. As an alternative to allografts such as Lyodura, we developed a dural substitute from synthetic bioabsorbable polymers which are completely free from potential risk of latent virus infection. Finally, our experience in tissue engineering for skull bone regeneration using growth factors coupled with polymeric carriers is presented to demonstrate the promise of tissue engineering in the future.

Aneurysm↗

Focus on: Johnson City Medical Center Hospital Biomedical Engineering Department.

The Biomedical Engineering Department at Johnson City Medical Center Hospital, Johnson City, Tennessee, is responsible for servicing over 2,500 pieces of equipment. The department also provides biomedical services, on a contract basis, to six area hospitals and ten physicians' offices. The department is extensively involved in pacemaker implants and participates in the hospital's system of equipment specification and selection. The department was established in 1974, as the region's first hospital-based biomedical engineering department with a staff of one. It has grown to a staff of five including two certified BMET's and one certified clinical engineer. Affiliation with a medical school brings new technology which challenges the department to future growth.

Biomedical Engineering↗

Technology assessment in healthcare: a means for pursuing the goals of biomedical engineering.

The goals of biomedical engineering include the improvement of health and life quality of mankind. However, the contribution of biomedical engineering to those worthy ends must be more clearly related. Biomedical engineers should become more active in demonstrating to policymakers and other parties in healthcare the value of the contributions of healthcare technology. Technology assessment (TA) is a form of investigation designed to identify and evaluate the implications of technologies so as to inform policymaking. Among the important trends in TA that should be of special interest to biomedical engineers are the increasingly higher methodological standards for accepting evidence from clinical investigations, and the use of quality-of-life measures for determining how technologies affect people's lives.

Biomedical Engineering↗