[A new atropine derivative for the treatment of airway obstruction].
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Ipratropium exerted marked bronchodilating effects in 22 patients with chronic obstructive lung diseases. The tolerance of the drug was excellent. In long-term treatment the patients do not get accustomed to the drug.
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1. Oxotremorine exerts an action on peripheral cholinoceptors in the anaesthetized rat. After the blockade of peripheral cholinoceptors with the quaternary atropine derivative, atropine methylbromide, oxotremorine produced a rise in arterial blood pressure and tachycardia.2. The rise in arterial pressure and tachycardia was absent in rats that had been pithed or had undergone high spinal cord transection.3. A non-quaternary atropine derivative antagonized these cardiovascular effects.4. Drugs which inhibit activity of the sympathetic nervous system antagonized the oxotremorine-induced hypertension and tachycardia.5. It is concluded that the rise in arterial pressure and tachycardia seen in the anaesthetized rat treated with a quaternary derivative of atropine is due to an action of oxotremorine on the central nervous system at a supraspinal level, resulting in an increase in activity of the efferent sympathetic nervous system.
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Diastereomeric urethane derivatives of atropine (d,l-hyoscyamine) and l-hyoscyamine were prepared by reacting the alkaloids with (-)-1-phenylethylisocyanate. The derivatives, as the picrate ion-pairs, were characterized by their melting points, optical rotations, elemental analyses, and IR, NMR, and UV-visible spectra.
Atropine derivatives. The presence of atropine derivatives in numerous combined medicines is often ignored or reflected. A case report of prolonged bilateral non reactive mydriasis with "cycloplegia", linked with the utilisation of a therapeutic dose of Lameline suppositories raises the question of individual susceptibility, with particular ocular sensitivity. This urge one not to ignore the presence of these products and to respect the contraindications, even with minute doses.