DNA critics appointed to advisory committee.
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The Children's Special Health Care Services Advisory Committee is an advisory group that includes stakeholders in the delivery of care for children with special health-care needs. An emphasis has purposely been placed on consumer participation to ensure adequate voice and balance with other provider, legislative, and bureaucratic interests. The Advisory Committee has assumed an aggressive and complete role in reviewing and recommending every aspect of the program. As a result of this active co-ownership, the program has repeatedly survived threats of serious budget cuts and reductions to its base. Agreement between providers and consumers on values, structure, and operational needs has been reached. A win-win approach has been possible, not only in the planning and growth of the program but also in the policy arena, legislatively, and with the administration.
A questionnaire survey was undertaken to determine how prevalent community advisory committees have become in the nation's dental schools and what types of committees have been formed. Responses were received from 52 (90 percent) of the 58 dental schools. The data revealed the following: 1. Nine schools (17 percent) have developed consumer committees. 2. The number of committee members varies from five to 29. 3. All the committees are composed of consumer members and school representatives, and, in all but one committee, health care providers are represented. 4. Four (44 percent) committees have advisory functions only, while the remaining five (56 percent) play an advisory and policy-making role. 5. No committee planned formal training sessions for their consumer members. 6. Of the 43 schools (83 percent) without such a committee, seven (16 percent) replied they foresee implementing a consumer committee in the future.
Although it is understood that an advisory committee is "a group of persons outside the educational institution chosen from the community to advise those who are responsible for the planning, implementing, and maintaining of an educational program in radiologic technology that will meet the needs of a community, region, state, or nation," it is advice we buy at a price. No, the price is not in monetary values, but the price of forethought, planning, good organization and effective use of that committee.
Possibly the most far-reaching, controversial research currently being conducted in the international biological science community involves human gene therapy experimentation. In this paper, I report the dynamics of the political process which ultimately found the Recombinant DNA Advisory Committee (RAC) of the National Institutes of Health approving for the first time protocols of this genre. A full appreciation of the policy-making dialogue shows that significant participants perceived the process from very different vantage points regarding the way in which the American political system works and the way in which it ought to work. I argue that, if we are to understand how the RAC should proceed in orchestrating a human gene therapy policy agenda, then we must flesh out and critically analyze these competing vantage points. To that end, I postulate seven possible "action models" for characterizing how protocol assessments of the type at issue might be developed given the nature of our politics, reaching the conclusion that one of these models holds out the most promise for synthesizing efficaciously the key factors involved. In conclusion, I discuss how the RAC might profitably employ this preferred strategy in these and other cases.
This supplementary statement provides information on and recommendations for the use of diphtheria and tetanus toxoids and acellular pertussis vaccine (DTaP). One such vaccine was recently licensed, ACEL-IMMUNE.* This vaccine is licensed for use only as the fourth and fifth doses of diphtheria, tetanus, and pertussis vaccination; it is not licensed for the initial three-dose series in infants and children, regardless of age. At least one other DTaP product is anticipated to be licensed in the future for use as the fourth and fifth doses. The current Immunization Practices Advisory Committee (ACIP) statement on diphtheria, tetanus, and pertussis issued August 8, 1991, gives general recommendations on pertussis prevention, including the use of whole-cell pertussis vaccines for primary and booster vaccination (1).
Currently three Haemophilus influenzae type b (Hib) conjugate vaccines are licensed for use in Canada in infants 2 months of age and older: HibTITER (Lederle Laboratories), PedvaxHIB (Merck Sharp & Dohme Canada) and Act-HIB (Pasteur-Mérieux, distributed in Canada by Connaught Laboratories Ltd.). A fourth vaccine, licensed both as a single product (ProHIBIT) or in combination with diphtheria toxoid-pertussis vaccine-tetanus toxoid (DPT-Hib) (Connaught), is limited to use in children 18 months of age or older. The following recommendations incorporate those previously published by the National Advisory Committee on Immunization(1), provide information on Act-HIB (which was licensed in March 1992) and summarize recently published data on the comparative immogenic effects and interchangeability of Hib conjugate vaccines (2-6).
The Acyclovir in Pregnancy Registry was established to gather data on prenatal exposure to acyclovir. Exposed pregnancies are tracked prospectively to ascertain exposure, risk factors, and pregnancy outcome. Through June 30, 1990, 312 acyclovir-exposed pregnancies had been reported and followed. Of these, 239 were exposed during the first trimester; outcomes included 24 spontaneous fetal losses, 47 induced abortions, 159 live births of infants without congenital abnormalities, and nine outcomes with congenital abnormalities. Among the 73 second- and third-trimester exposures, one infant was born with an abnormality. Exposures are also reported to the registry retrospectively, ie, after the outcome of pregnancy is known. Registry findings to date do not show an increase in the number of birth defects among the prospective reports when compared with that expected in the general population, and there is no consistent pattern of abnormalities among retrospective or prospective reports. These findings should provide some reassurance in counseling women following inadvertent prenatal exposure. The cases accumulated to date represent a sample of insufficient size for reaching reliable and definitive conclusions about the safety of acyclovir for pregnant women and their developing fetuses. Therefore, until further information is available, the Acyclovir in Pregnancy Registry Advisory Committee recommends following the 1989 Centers for Disease Control Sexually Transmitted Diseases Treatment Guidelines for the use of acyclovir in pregnancy, and encourages reporting of all prenatal exposures to the registry (1-800-722-9292, ext. 8465).
BACKGROUND: In 1989 and 1990, measles reached epidemic proportions in the United States, including several areas of California. Children's Hospital Oakland (Calif), a major health care provider for children in a measles epidemic area of California, reported 131 cases between 1989 and 1991, the largest number ever reported by that institution. In February 1990, four cases of measles were reported among hospital staff. Continued risk of nosocomial infection prompted the development of a program to ensure that all hospital staff were adequately protected against measles. METHODS: All hospital employees who were unable to document proof of measles immunity were required to be serologically screened for measles antibody and to be vaccinated against measles if they were determined to be nonimmune. Serologic screening was performed in-house with a commercially available enzyme-linked immunosorbent assay measles antibody test. Dates of birth were recorded for all employees screened. Individuals with negative or repeatedly equivocal results were considered to be nonimmune and were vaccinated with trivalent measles-mumps-rubella vaccine. RESULTS: Between March and June 1990, 1694 staff were serologically tested for measles antibody. Eighty-nine (5.3%) of the employees were considered to have inadequate immunity. Forty (45%) of these susceptible individuals were born before 1957. CONCLUSIONS: We conclude that the recommendations of the Immunization Practices Advisory Committee should be expanded to include serologic screening or vaccination of hospital personnel who were born before 1957. Serologic screening of hospital staff may be a reasonable alternative to vaccination under certain circumstances.
Since the publication of the Revised European-American Classification of Lymphoid Neoplasms in 1994, subsequent updates of the classification of lymphoid neoplasms have been generated through iterative international efforts to achieve broad consensus among hematopathologists, geneticists, molecular scientists, and clinicians. Significant progress has recently been made in the characterization of malignancies of the immune system, with many new insights provided by genomic studies. They have led to this proposal. We have followed the same process that was successfully used for the third and fourth editions of the World Health Organization Classification of Hematologic Neoplasms. The definition, recommended studies, and criteria for the diagnosis of many entities have been extensively refined. Some categories considered provisional have now been upgraded to definite entities. Terminology for some diseases has been revised to adapt nomenclature to the current knowledge of their biology, but these modifications have been restricted to well-justified situations. Major findings from recent genomic studies have impacted the conceptual framework and diagnostic criteria for many disease entities. These changes will have an impact on optimal clinical management. The conclusions of this work are summarized in this report as the proposed International Consensus Classification of mature lymphoid, histiocytic, and dendritic cell tumors.
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This paper profiles the epidemiology of tuberculosis in a geographically defined area, the Eastern Health Board. In 1990, 191 new cases of the disease were notified, 15.5/100,000. One hundred and eighty five were from the indigenous population. Fifty four per cent were male. Nearly 50% of all cases occurring in females do so in those under 35 years and for males, 45% occur in those less than 45 years. One hundred and three (54%) had pulmonary tuberculosis alone and only 50 (26%) had a presumptive diagnosis. Although the lower social classes were overrepresented, cases occurred throughout all social classes and a significant proportion were either gainfully employed or in full time education. Data on BCG status was incomplete, however 28 cases were known to have had BCG at some stage of their life. Thirteen cases were also known to be HIV positive. The contact tracing process was responsible for locating 33 (17%) cases. Continuing surveillance both at national and local level is required in order to assist eradication.
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