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Results for “Aborted Fetus”

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At least 19 recordsLinked to original sources
PubMed1979

The indirect fluorescent antibody technique as a method for detecting antibodies in aborted fetuses.

In this investigation the indirect fluorescent antibody technique was used to titrate antibodies in bovine sera to parainfluenza 3, infectious bovine rhinotracheitis virus and bovine viral diarrhea virus. These results were compared to those determined on the same samples by hemagglutination inhibition for parainfluenza 3 virus and serum neutralization for bovine virus diarrhea and infectious bovine rhinotracheitis virus. The results of the serological methods agreed closely. The indirect fluorescent antibody technique is a rapid and sensitive method for detecting antibodies and the procedure lends itself to use in diagnostic laboratories. In addition to the above viruses the presence or absence of antibodies to bovine coronavirus and bovine adenovirus 3 were determined by the indirect fluorescent antibody technique in thoracic fluids from 100 aborted fetuses and 50 nonaborted fetuses. Results on these samples were not compared to hemagglutination inhibition or serum neutralization as the condition of fluid samples from aborted fetuses renders interpretation of such tests unreliable. Antibodies to one or more viruses were detected in 30 of the 100 aborted fetuses and in seven of the 50 nonaborted fetuses. Antibodies to more than one agent were detected in eleven of the 100 aborted and in one of the 50 nonaborted fetuses. Reasons for this occurrence and application of the test in determination of causes of abortion are discussed.

Abortion, Veterinary↗
PubMed2025

Molecular Detection and Characterization of Bovine Diarrhea Virus (BVDV) in Aborted Fetuses and Semen Samples from Paraguay.

Bovine viral diarrhea virus (BVDV) is the most prevalent pathogen in cattle and causes significant economic losses due to its severe clinical manifestations. It belongs to the family Flaviviridae and is distributed in species A, B, and H within the genus Pestivirus. The objective of this study was to detect and characterize BVDV using molecular techniques (RT-PCR) in semen and aborted fetuses samples that were sent to the CEDIVEP (Veterinary Diagnostic Center of Paraguay) laboratory. Seventy-three samples of semen from bulls were analyzed, and 54.7% of the samples were positive for Pestivirus A. The presence of Pestivirus A and H was detected in 2/8 spontaneously aborted fetuses. The genotypes of four individual samples of type A and four samples of type H organs were confirmed by partial sequencing of the 5-UTR region. The presence of BVDV was confirmed by molecular techniques for the first time in our country through its detection in different types of samples, as well as the presence of two genotypes. This suggests that the circulation of this virus can cause significant losses in cattle production in Paraguay.

Diarrhea Viruses, Bovine Viral↗
PubMed1977

[Demonstration of the infectious rhinotracheitis-pustular vuluovaginitis virus (IBR-IPV) in the placenta and aborted fetuses of cows].

A well expressed correlation was found to exist between the immunofluorescence and the histologic methods in the demonstration of IBR-IPV infection of fetuses and placentae in 75 cases of spontaneous undiagnosed abortions. If those that were positive by the immunofluorescence method were 100 per cent as many as 87 per cent of them showed coincidence with the results obtained by the histologic method. The isolation of the virus of IBR-IPV coincided in 44 per cent of the cases only. Clearest specific fluorescence, established most frequently, was demonstrated in the kidneys of the fetuses. It was found that contrast staining with Evans blue effectively inhibited the unspecific fluorescence. Exceptions in this respect were observed with some preparations of liver, lung, and placental tissues, where there were cells of unspecific fluorescence, which, by its character and localization differed essentially from the fluorescence that was specific for IBR-IPV. It is assumed that the immunofluorescence method performed at contrast staining with Evans blue makes possible the fast and precise diagnosis of IBR-IPV.

Abortion, Veterinary↗
PubMed1978

Partial trisomy 18(q11 leads to qter) in an infant and aborted fetus resulting from a balanced paternal translocation t(13;18)(q32:q11).

Partial trisomy 18 is described in a two month old female with severe mental, motor and growth retardation, associated with multiple congenital anomalies characteristic of complete trisomy 18. Trisomy for almost all of 18q resulted from adjacent I segregation of a paternally inherited translocation t(13; 18)(q32:q11). The balanced translocation was observed in three generations of the family. Partial trisomy 18q identical to that observed in the proband was found in a subsequent miscarriage.

Abnormalities, Multiple↗
PubMed1978

[Isolation of adenovirus type 1 from aborted cattle fetuses].

Five adenoviral strains, typed as adenovirus type 1, were isolated from aborted cattle foetuses, taken from farms with abortions in cows. The viruses were isolated from kidneys, lungs and livers of the foetuses. They were isolated from the kidney most frequenty (three strains). Intranuclear basophilic inclusions in the alveolar epithelium of the lungs and in the tubular epithelium of the kidneys have been established in the histological investigations of the internal organs of the foetuses. The isolation of adenoviruses from foetuses has been discussed as an infectious process, emerging as a result of a transplacental infection.

Abortion, Veterinary↗
PubMed1979

Prenatal diagnosis of the hemoglobinopathies: ethical issues.

Prenatal diagnosis of the hemoglobinopathies has been increasingly reported. This article discusses those ethical issues stemming from pregnancy studies by fetoscopy or placental aspiration: diagnostic accuracy and safety for mother and fetus, abortion of the fetus diagnosed as homozygous for thalassemia or sickle cell diseases, and access to prenatal diagnosis for those who cannot afford it. The author's position on these issues attempts to mediate between the poles in current ethical debate on abortion in public policy.

Abortion, Therapeutic↗
PubMed1979

Fetal to adult hemoglobin switch in cultures of early erythroid precursors from human fetuses and neonates.

Erythroid burst colonies derived from the cord blood of nine neonates and from the blood and liver of three fetuses aborted after 20 weeks of gestation were grown in plasma clot culture. Their quantitative study revealed a higher proportion of burst-forming units (BFU-Es) in cord blood than in cord blood of normal adults. In addition, colony-forming units (CFU-Es) were present in cord blood but absent from adult blood. Study of haemoglobin synthesis in 14-day cultures of cord blood BFU-Es showed a significantly higher degree of Hb A synthesis than was found in reticulocytes from fresh cord blood; this proportion was, however, similar to that expected in vivo about three weeks after birth. These data suggest that the hemoglobin switch is already programmed in most of the early erythroid precursors present in cord blood or full-term neonates and indicate that the differentiation time is probably of the same order of magnitude in vivo and in vitro. The proportion of Hb A and F synthesis in erythroid bursts was not influenced by the concentration of erythropoietin in the range studied--ie, from 0.5 to 12 international units. Low but identical proportions of Hb A synthesis were found both in erythroid cells from liver after two hours of incubation with [3H]-leucine, and in 14-day liver bursts from fetuses aborted at 20 weeks of gestation.

Adult↗
PubMed1977

Lymphatic malformation in human fetuses. A study of fetuses with Turner's syndrome or status Bonnevie-Ullrich.

In 7 spontaneously aborted fetuses characterized by a large cystic hygroma in the nuchal region and a prominent and generalized edema, the structure and extension of the lymphatic system was studied. In all fetuses marked malformations of this system were found. Although the morphologic appearance seemed to vary greatly it is suggested that the disorder is essentially a generalized hypoplasia and partial agenesis of the lymphatic system, which ceases to extend peripherally at an early embryonic stage. A suggestion as to the mechanism of this growth inhibition is made.

Female↗
PubMed1977

Ocular ultrastructural study in a fetus with type II glycogenosis.

The general pathological and ocular studies in an aborted fetus with type II glycogenosis revealed the widespread lysosomal storage of glycogen. Obvious lesions are observed in the viscera, in the skeletal and ocular muscles, and in all ocular tissues except the pigment epithelium of the retina. Brain and heart are relatively spared. Conjunctival and skin biopsies have a diagnostic importance, since specific alterations are evident early in the course of the disease.

Conjunctiva↗
PubMed1979

Etiology of neural tube defect in man--Do teratogens play any part? Evidence from sex ratios.

Neural tube defect (NTD) is more common among spontaneously aborted fetuses than in infants born in the third trimester, but there is no direct evidence that NTD-affected conceptuses, presenting at these two different gestational ages, are components of a single disease process. Evidence for homology is here presented in an analysis of the sex ratios of spontaneously and therapeutically aborted NTD-affected fetuses, and of sex ratios differing with variations in prevalence of NTD-affected infants. If it could be shown conclusively that NTD is a single disease process, with an inverse relationship between components expressed early and late in gestation, there would be implications for the ascertainment of families at risk for NTD, and for the search for environmental factors potentially involved in the causation of NTD.

Abortion, Spontaneous↗
PubMed1978

Kinetics of the complement fixing and immunofluorescent antibody response in experimental chlamydiosis in ewes.

Normal, 70 days pregnant ewes were inoculated i.v. with a chicken embryo grown Chlamydia psittaci strain. The ewes presented a biphasic febrile curve and aborted 30 to 68 days after inoculation. Chlamydiae were isolated from aborted fetuses and from vaginal swabs. Ewes developed CF and IF antibodies titrating 1:320 to 1:1024 two to three weeks after inoculation. A second antibody rise occurred one to two weeks before or after abortion and reached titers of 1:640 to 1:1024. Immunoglobulin fractions from the serum of the ewes were also tested by CF and IF. IgG antibodies were detected by both methods and the trend of their kinetics was similar to that of whole serum. IgM antibodies were present in very low titers in the immunoglobulin fractions of some of the animals. CF and IF were equally sensitive in detecting anti-Chlamydia antibodies in whole serum or immunoglobulin fractions.

Abortion, Veterinary↗
PubMed1977

[Epizootologic study of aspergillosis abortions in cows].

Studied were mycologically a total of 463 aborted fetuses from 32 farms in the district of Roussé in 1972-1974. The pathogenic Aspergillus fumigatus fungus was established in 16.19 per cent of the cases. Abortions occurred the year round, becoming more frequent on the hot and wet days in summer and autumn as well as at in-door rearing and inappropriate hygiene conditions in winter. Most frequently abortions set in between the third and seventh month of pregnancy, which should be taken into consideration in diagnosing the disease.

Abortion, Veterinary↗
PubMed1978

Prenatal diagnosis of homozygous familial hypercholesterolaemia. Expression of a genetic receptor disease in utero.

Cultured amniotic-fluid cells from a fetus at risk for homozygous familial hypercholesterolaemia (F.H.) almost completely lacked cell-surface receptors for plasma low-density lipoprotein (L.D.L.), as evidenced by direct measurement of binding, uptake, and degradation of 125I-L.D.L. Functional consequences of L.D.L. binding to the receptor--i.e., suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase and stimulation of cholesterol esterification--were proportionately reduced when compared with results in cultured amniotic cells from two control fetuses. On the basis of these findings, homozygous F.H. was diagnosed and the pregnancy was terminated at the 20th week. The diagnosis of homozygous F.H. was confirmed by a serum-cholesterol of the aborted fetus of 279 mg/dl, a value 9 times the mean of four control fetuses of similar gestational age. More than 80% of the serum-cholesterol of the affected fetus was contained within L.D.L. Prenatal diagnosis of homozygous F.H. now seems practical; moreover, the finding of a raised serum-L.D.L. in the affected fetus indicates that the L.D.L. receptor is normally functional as early as the 20th week of fetal life.

Adult↗
PubMed1975

[Isolation and identification of a virus causing abortions and stillbirths in swine (Preliminary report)].

A virus of the RNA type, having no lipid envelope, acid-fast and stable to heat, was isolated from an aborted fetus and from the kidney of a piglet of a lower viability at birth. It was readily cultured, multiplying quickly in primary cell cultures of pig kidney and in the SPEV cell line, producing a characteristic cytopathic effect. It gave no hemagglutination with human, chicken, and swine erythrocytes. Serologically, it was identified as a swine enterovirus of serotype I, identical with the viruses described as the etiologic agents of SMEDI.

Abortion, Veterinary↗