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Results for “ANTISEPTICS/effects”

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At least 19 recordsLinked to original sources
PubMed1958

Local action of some antibacterial substances against Corynebacterium ovis in guinea-pig skin.

When a suspension of living Corynebacterium ovis was injected intradermally in guinea-pigs, a lesion of roughly circular outline developed within 24 hr. Lesions of smaller diameter arose if benzylpenicillin, dequalinium, hedaquinium, cetrimide, or oxytetracycline were injected at the identical site, either before, with, or after C. ovis. Evidence has been obtained that such reductions of lesion diameter are due to direct action of drugs on bacteria and not to antitoxic or anti-inflammatory actions. Lesion diameters became less as drug dosage increased up to a limit, and these reductions provided a measure of local antibacterial action in vivo. Intradermal injection of higher concentrations of antibacterials, without C. ovis, produced comparable but somewhat flatter lesions, diameters of which increased with increasing concentration of drug and provided a measure of intradermal toxicity.

Animals↗
PubMed1959

Factors influencing the effect of beta-propiolactone on chromosomes of Vicia faba.

The effect of beta-propiolactone on chromosomes is independent of pH, oxygen tension, and some metabolic inhibitors. It is influenced by temperature, concentration, and pretreatments with dinitrophenol. henol. Interphase sensitivitycalizationand localization of breaks are discussed in terms of the action of beta-propiolactone and the relationship of gamma-propiolactone to other radiomimetic compounds.

Anti-Infective Agents, Local↗