Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “ANTACIDS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMed1983

Effect of antacids on intragastric pH in healthy subjects and duodenal ulcer patients. Influence of the size of the antacid dose and of anticholinergics.

Different doses of two liquid antacids, alone and combined with an anticholinergic agent, were studied with respect to the duration of antacid action. The studies were performed in healthy subjects with MAO less than 30 mmol/h and in duodenal ulcer patients with MAO greater than 35 mmol/h. Gastric pH was recorded using radiotelemetric technique (Heidelberg capsule). In the healthy subjects, there was no significant difference in the duration of action with the different doses but in duodenal ulcer patients a tenfold increase of the antacid dose resulted in a doubling of the duration of action. Combined treatment with an anticholinergic and antacids enhanced the antacid effects in both groups. It is concluded that an antacid dose should be so great that it binds secreted acid before the dose leaves the stomach. Further increase of the dose will not increase the duration. Concomitant use of an anticholinergic agent increases the duration of antacid action.

Adult↗
PubMed1985

Antacid regimen in reducing gastric fluid acidity--comparison of conventional oral antacids with cimetidine.

281 patients, divided into two groups, were given single 30 ml dose of five different conventional oral antacids (sodium citrate, 0.3 M Maalox, Gelusil, Alludrox and Mucaine), separately and in combination with Cimetidine to study their effect on decreasing the acidity of stomach contents. In 181 patients receiving varying types of conventional oral antacids, 2-10 percent of the patients had pH less than 3, regardless of the antacid received. In 100 patients of Cimetidine plus antacid group, none of the patients had pH less than 4.83, maximum being 8.2. With thick particulate oral antacids, no-mix between gastric juice and antacid was noticed in approximately 5-10 percent of cases. Cimetidine combined with oral antacid was the safest regimen to reduce the gastric fluid acidity.

Adolescent↗
PubMed1986

A double-blind controlled study to compare the efficacy of an antacid plus oxethazaine with that of an antacid alone in the treatment of pain due to gastric or duodenal ulceration.

A double-blind study was carried out in 40 patients with typical ulcer pain and suffering from gastric or duodenal ulcer to compare the pain-relieving efficacy of oxethazaine/magnesium and aluminium hydroxide mixture with that of the antacid combination alone. Patients took 8 ml doses of either treatment when necessary over a period of 4 weeks. Both treatment regimens were equally effective in reducing the painful symptoms of peptic ulceration, but the total volume of medication required to achieve adequate symptomatic relief was less in patients taking antacid plus oxethazaine than in patients taking antacid alone. It is suggested that the combination of oxethazaine plus antacids, therefore, is to be preferred, because, by allowing a reduction in the intake of antacid, the risk of side-effects due to antacid therapy is thereby reduced.

Adult↗
PubMed1979

[Acetlysalicylic acid, protective antacid effect and lesions of the gastric mucosa. Effect of acetylsalicylic acid and an antacid drug (Gastropulgit Tabs) on the transmural electric potential in the human stomach].

Antacids are able to prevent acetylsalicylic acid-induced functional and morphological changes of the gastric mucosa. In order to test whether a new antacid in chewing-tablet form (Gastropulgit Tabs) might be able to protect the gastric mucosa from acetylsalicylic acid-induced functional changes similarly to liquid antacids the effect of this antacid on acetylsalicylic acid-induced changes of transmural gastric potential difference was measured in healthy volunteers. The decrease of transmural potential differences induced by 640 mg acetylsalicylic acid could be prevented by simultaneous addition of 2 tablets of Gastropulgit Tabs. Thus the antacid in tablet form is able-like liquid antacids-to protect the gastric mucosa against acetylsalicylic acid-induced functional changes.

Alum Compounds↗
PubMed1982

Double-blind controlled trial of bethanechol and antacid versus placebo and antacid in the treatment of erosive esophagitis.

To determine the value of bethanechol in the treatment of erosive esophagitis, a double-blind study was undertaken in which 28 patients were randomized to either bethanechol and antacid, or placebo and antacid. Patients were evaluated clinically, endoscopically, and by esophageal manometry before and after 8 wk of therapy. After treatment both groups showed significant improvement in heartburn and in healing of esophageal lesions. Patients who received bethanechol plus antacids did not show a greater improvement than patients who received placebo plus antacids in any category, nor did patients in the bethanechol-treated group have a greater incidence of complete healing. In addition, pretreatment mean lower esophageal sphincter pressure was normal in approximately 30% of patients with erosive esophagitis and this finding was associated with a greater chance for complete healing of esophageal lesions. These results fail to show that the addition of bethanechol to an intensive antacid regimen is more effective than the antacid regimen alone in the treatment of erosive esophagitis and that patients with esophagitis and normal lower esophageal sphincter pressures respond more favorably to medical treatment.

Antacids↗
PubMed1997

Interaction of an aluminum-magnesium containing antacid and gastric mucus: possible contribution to the cytoprotective function of antacids.

BACKGROUND: Antacids are generally thought to protect the gastric mucosa from damage primarily by their ability to neutralize hydrochloric acid, but recently other mechanisms of antacid cytoprotection have been suggested. The aim of our study was to determine if the antacid hydrotalcit (Mg6Al2(OH)16CO3 x 4H2O) and its clinical formulations Talcid (suspension and tablet) can influence the acid barrier properties of pig gastric mucus (PGM). METHODS: Viscosities, flow patterns of injected HCl, and permeability to HCl were assayed in solutions of PGM with and without added antacid. RESULTS: Talcid-suspension markedly increased mucin viscosity between pH 2 and 7. In contrast, powdered Talcid-tablet and hydrotalcit noticeably reduced mucin viscosity at pH 5 and below. HCl barely diffused through PGM-Talcid-suspension, whereas the acid was able to quickly penetrate a PGM-Talcid-tablet powder or PGM-hydrotalcit mixture. When injected into a mixture of PGM-Talcid-suspension, HCl travelled in a single distinct channel whereas in both PGM-Talcid-tablet powder or PGM-hydrotalcit mixtures, the acid mixed irregularly throughout. Experiments with antacids alone revealed that Talcid-suspension, but not Talcid-tablet nor hydrotalcit, had barrier properties similar to PGM. CONCLUSION: Talcid-suspension has viscoelastic features similar to gastric mucin and may afford mucosal protection by its ability to maintain or mimic the barrier properties of gastric mucus gel. In contrast, powdered Talcid-tablets and hydrotalcit reduce the barrier function of gastric mucus.

Aluminum Hydroxide↗
PubMed1977

[Peptone-stimulated gastric secretion and antacids. Effect of antacids with various content of calcium, magnesium and aluminiumions on the peptone-induced secretion of gastric juice, double-blind study].

A double-blind-trial was performed to prove the effect of antacids containing Mg (OH)2, Al (OH)3 and CaCO3 on peptone-stimulated gastric secretion (intragastric titration). A high efficacy of antacids given after meals was demonstrated. After application of antacids no significant rise in serum gastrin levels during intragastric titration was found. Serum calcium and magnesium levels remained unchanged. Peptone-stimulated gastric secretion was not influenced by application of different antacids within a period of 2 hours.

Aluminum↗
PubMed1987

[Lattice structure antacids and antacid mixtures].

In the last years the importance of the evaluation of antacid compounds according to their neutralizing capacity decreased. Clinical investigations have shown that antacid mixtures of aluminum-magnesium hydroxide healed gastric an duodenal ulcers (neutralizing capacity 100-150 mmol/day) as well as H2 receptor antagonists and better than a placebo. By this the necessary daily dosage could be reduced essentially. This paper presents studies showing that lattice like structured antacids (e.g. Magaldrate) healed gastric and duodenal ulcers (neutralizing capacity 100-350 mmol/day) as well as Ranitidine (150 mg b.d.). Maintenance therapy should be evaluated critically because sufficient data are not available and mineral metabolism is changed significantly by extremely small dosages of aluminium-magnesium hydroxide antacids even in patients with normal kidney function.

Aluminum Hydroxide↗
PubMed1984

In vitro comparison of the antacid potencies of almagate in tablets and suspension with those of other commercially available antacid preparations.

Almagate (hydrated aluminium-magnesium hydroxycarbonate, Al2Mg6(OH)14(CO3)2 X 4 H2O, Almax) in the form of tablets and suspension was compared with other commercially available antacid preparations in a battery of tests designed to evaluate antacid activity and related properties. The evaluation of an antacid should take into account, in addition to total acid neutralising capacity, neutralising capacity under dynamic conditions related to in vivo events, bioavailability, speed of action, lack of possible rebound effect and low sodium content. When these considerations are taken into account Almax tablets and suspension can be classified as highly effective antacids retaining a high proportion of their total neutralising capacity under simulated in vivo conditions. As in the case of the active principle, almagate, the enzyme pepsin has a positive effect on acid neutralising activity.

Aluminum Hydroxide↗
PubMed1991

[Antacid therapy of upper abdominal symptoms. Double-blind study on the effect and tolerance of 2 antacids in gastritis , esophagitis and functional upper abdominal symptoms].

In a randomized, multicenter, double-blind study involving a total of 97 patients, the effectiveness and tolerance of Gelofalk, a new type of antacid combination comprising smectite--a natural alum earth, the specific molecular structure of which permits it to bind aggressive substances particularly well--aluminium hydroxide and magnesium hydroxide were investigated in comparison with a commercially available aluminium hydroxide antacid used by patients with gastritis, esophagitis and functional upper abdominal complaints over a treatment period of 4 weeks. The buffering capacity of a daily dose of Gelofalk was 135 mval, in the case of the reference antacid 210 mval. In terms of pain relief, reduction of accompanying symptoms, and endoscopic healing properties, Gelofalk proved very effective. Because of its particular properties, the preparation proved significantly superior to an aluminium hydroxide suspension in the case of most test parameters, in particular pain relief, onset of effect and heartburn. Gelofalk was very well tolerated; constipation or diarrhea occurred in only 2 cases each.

Abdominal Pain↗
PubMed1976

An antacid tasting: the relative palatability of 19 liquid antacids.

The taste of liquid antacids is proposed as a major factor in patient compliance in taking such medication when prescribed. A study was made of the relative palatability of 19 antacids. The antacids can be divided into three groups of varying palatability (p less than 0.05).

Antacids↗
PubMed1986

Small bowel obstruction from an antacid bezoar: a ranitidine-antacid interaction?

A 63-year-old man had an acute small bowel obstruction while being treated with ranitidine and self-prescribed antacid. On exploration, a firm mass, chemically similar to the ingested antacid, was found impacted in the terminal ileum. We believe the effect of ranitidine on gastric secretory volume was the cause of the antacid concretion.

Aluminum Hydroxide↗
PubMed1984

Comparison of dicyclomine with antacid and without antacid in dyspepsia.

In a study of forty-two patients with dyspepsia, hiatus hernia or duodenal ulcer, dicyclomine (Merbentyl) has been demonstrated to be effective in the control of the symptoms of this disorder. Under double-blind conditions an antacid or placebo supplement was provided and no significant difference in benefit was recorded. The antacid was given in a large tablet and this preparation was more conscientiously taken by patients, and this was equally true for large placebo tablets. Clearly patients like to take frequent treatment for dyspepsia, but symptom control is quite adequate if Merbentyl is given alone.

Antacids↗
PubMed1977

[Antacids and gastric mucosa. Protective effect of an antacid on acetylsalicylic acid induced functional lesions in the human gastric mucosa].

Salicylates do induce functional and morphological changes of the gastric mucosa: increased H+-back-diffusion, increased Na+-influx, and increased blood loss. Several functional parameters of the gastric mucosal barrier correlate with the transmural electrical potential difference (PD) which can be used as a sensitive, but unspecific parameter to detect functional changes of the gastric mucosal barrier. The effect of a salicylate alone and in presence of a liquid antiacid (Gastropulgit Gel) on transmural PD was measured in healthy volunteers. The presence of an antacid prevented the salicylate-induced drop of transmural PD. The tested antacid seems to exert a protective effect towards acute damage of the gastric mucosa induced by salicylates.

Antacids↗
PubMed1989

Studies of neutralizing properties of antacid preparations. Part 7. 27Al NMR studies of aluminum species formed during acid dissolution of some antacid preparations.

Neutralization of some aluminum containing antacid preparations with hydrochloric acid were studied by 27Al NMR spectroscopy. It has been found that the nature and composition of aluminum species produced during the acid dissolution of preparations depends upon the substance used and on the pH at which the neutralization reaction proceeds. The results are consistent with the presence of both monomeric and polymeric species in solution containing aluminum in octahedral and tetrahedral environments.

Aluminum↗
PubMed1984

Effect of proteolytic enzymes and polypeptides on the antacid activity of almagate and other antacids.

The acid neutralizing capacity of almagate (hydrated aluminium-magnesium hydroxycarbonate, Al2Mg6(OH)14(CO3)2 X 4H2O, Almax), magaldrate and an aluminium-magnesium hydroxide cogel was measured in the presence of different concentrations of pepsin or peptone. The crystalline antacids, almagate and magaldrate, when tested in the absence of polypeptides were less active acid neutralizing agents than the aluminium-magnesium hydroxide cogel but in the presence of the polypeptides they were considerably more active, especially in respect of time of neutralization. In the presence of pepsin, almagate was considerably more active than in the absence of this enzyme, whereas magaldrate suffered little change in activity and the dried aluminium-magnesium cogel was less active. The results demonstrate the importance of measuring acid neutralizing capacity in presence of naturally occurring polypeptides.

Aluminum Hydroxide↗