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PubMedDate not supplied

[Current indications for video-laparoscopic surgery of adrenal gland neoplasms].

Recent advances in pathophysiology of the adrenal glands suggest new indications for adrenalectomy. In open surgery large incisions are needed to remove a small gland; on the contrary, laparoscopic procedures offer new possibilities. The present study is a review of the literature on indications, contraindications and surgical technique of laparoscopic adrenalectomy. Evaluations of these initial experiences are favourable, however, due to the small number of patients operated and to the short follow up, a definitive opinion on the role of laparoscopic surgery for adrenalectomy has to be formulated.

Adrenal Gland Neoplasms↗
PubMed1998

bcl-2 expression in normal adrenal glands and in adrenal neoplasms.

Archival paraffin-embedded tissue from 5 normal adrenal glands (including 1 from a fetus of 28 weeks' gestation), 6 cases of adrenal cortical hyperplasia, 9 cortical adenomas, 14 cortical carcinomas, and 11 pheochromocytomas were immunostained with monoclonal antibody against bcl-2. Ultrastructural localization of bcl-2 protein was also performed on selected cases. Positive immunostaining for bcl-2 was seen in all of the layers of the normal adrenal cortex, with different staining characteristics. bcl-2 expression was never observed in the normal adrenal medulla. Electron microscopic studies revealed bcl-2 to be localized predominantly to mitochondria, with a small number of labels along the nuclear envelope. Analysis of adrenal neoplasms showed expression of bcl-2 in cortical tumors, but only one positive case in pheochromocytomas. Restriction of bcl-2 expression to adrenal cortex-derived tissue versus adrenal medulla-derived tissue might prove to be helpful for the differential diagnosis between cortical and medullary tumors.

Adolescent↗