Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “ACETYLSALICYLIC ACID”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMed1999

The photoprotective effect of ascorbic acid, acetylsalicylic acid, and indomethacin evaluated by the photo hen's egg test.

The aim of the present study was to evaluate the supposed photoprotective effects of ascorbic acid, acetylsalicylic acid, and indomethacin by the photo hen's egg test, a recently developed new model for phototoxicity. Therefore, in three independent experimental settings the blood vessel system of the embryo's yolk sac of 24 incubated hens' eggs (2 test groups) were exposed to 60 mJ/cm2 ultraviolet B (UVB) to induce severe phototoxic damage. Before UVB irradiation, one of these test groups was exposed additionally to one of the test substances and the other one to 0.9% sodium solution alone. To exclude plain toxic reactions, two additional test groups were exposed only to 0.9% sodium chloride solution or to one of the test substances alone. Over a test observation period of 24 h, the embryo lethality as well as the morphological changes of the yolk sac blood vessel system were observed. Ascorbic acid led to a significant and remarkable reduction of the UVB-induced damage. Acetylsalicylic acid also showed a significant but lower photoprotective capacity. In contrast, indomethacin showed no photoprotective effects in the photo hen's egg test.

Animals↗
PubMed1978

Comparative antiphlogistic activity of meseclazone, 5-chlorosalicylic acid, acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in various rat paw edema models.

The antiphlogistic activity of meseclazone and its major metabolite, 5-chlorosalicylic acid, have been directly compared to acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in rat paw edema induced by eleven different phlogistic agents. Based on the profile of activity and milligram/kilogram potency displayed by meseclazone, it most closely resembles acetylsalicylic acid and phenylbutazone in its mode of action.

Animals↗
PubMed1984

[Effects of acetylsalicylic acid on partial functions of human thrombocytes are not inhibited in vivo by salicylic acid].

Acetylsalicylic acid inhibits platelet function. In plasma acetylsalicylic acid is rapidly deacetylated to salicylic acid which is slowly eliminated and has no direct inhibitory effects on platelet function. However, salicylic acid prevents the inhibition by acetylsalicylic acid of collagen-induced aggregation of human thrombocytes in vitro. It was suggested that salicylic acid might inhibit the antiplatelet effects of acetylsalicylic acid in vivo and therefore low-dose acetylsalicylic acid would be more effective for antithrombotic therapy. A 500-mg tablet of acetylsalicylic acid applied 90 min after oral administration of 500 mg salicylic acid to six healthy male volunteers led to the same inhibition of collagen-induced platelet aggregation and tissue-extract-induced platelet stimulation as 500 mg acetylsalicylic acid alone. These results cannot give additional support to the recommendation of low-dose acetylsalicylic acid in the prevention of thromboembolic disease.

Administration, Oral↗
PubMed1985

Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man.

Healthy adults were given four diets, each one for one week: Low ascorbic acid diet, low ascorbic acid diet plus acetylsalicylic acid (3 g/d), high ascorbic acid diet (1 g/d) and high ascorbic acid diet plus acetylsalicylic acid. At low ascorbic acid intake, acetylsalicylic acid increased urinary ascorbic acid, but at high ascorbic acid intake, acetylsalicylic acid instead decreased urinary ascorbic acid. The latter effect was probably due to an inhibited intestinal absorbtion of ascorbic acid, and the former effect may reflect decreased protein binding and tissue uptake of ascorbic acid caused by acetylsalicylic acid. In no instance, acetylsalicylic acid affected plasma ascorbic acid. The effect of ascorbic acid on substances related to lipid peroxidation was investigated. The high ascorbic acid diets decreased plasma lipoperoxide and retinol binding protein. No change was observed in serum tocopherol, iron status, erythrocyte lipid fluorescence, plasma ceruloplasmin, urinary and plasma selenium and glutathione peroxidase activity. Thus, one-week supplementation of ascorbic acid seems to have only marginal effects on lipid peroxidation and antioxidant status.

Adult↗
PubMed2002

A flow-through solid-phase spectroscopic sensing device implemented with FIA solution measurements in the same flow cell: determination of binary mixtures of thiamine with ascorbic acid or acetylsalicylic acid.

A continuous and simple UV-photometric flow-through optosensor has been developed for the simultaneous determination of a binary mixture of two species with different electric charges present at very different concentrations - ascorbic acid (or acetylsalicylic acid) and thiamine. The sensing device is based on the selective sorption and determination of a cationic analyte on a cation-exchange gel (Sephadex SP-C25) while the other, anionic, analyte is determined in the solution among the interstices of the cation-exchange gel in the same flow cell. The analytes arrive in sequence at the sensing zone, which detects their intrinsic absorbance at 253 nm, as a result of on-line separation by use of a minicolumn filled with the same cation-exchange gel as in the cell, and placed before the flow cell. Thiamine is retained in the minicolumn whereas ascorbic acid or acetylsalicylic acid pass through it and produce their signal as a result of absorbance in the interstitial solution among the resin beads. Thiamine is then eluted from the precolumn, transported to the flow cell, and temporarily retained in the sensing zone from this eluted solution. Calibration graphs were linear over the range 3-50, 25-400, and 300-3000 microg mL(-1) (600 microL sample volume) and the relative standard deviations were 2.56, 1.85, and 1.25 % for thiamine, ascorbic acid, and acetylsalicylic acid, respectively. The proposed method was satisfactorily applied to the determination of binary mixtures of thiamine with ascorbic acid or acetylsalicylic acid in pharmaceutical preparations and semi-synthetic samples.

Ascorbic Acid↗
PubMed2001

[Prenatal effects of acetylsalicylic acid].

Acetylsalicylic acid is frequently ingested over-the-counter (OTC) drug, either as single or in combination with other drugs. It has been used in various diseases including that complicated pregnancy, such as preeclampsia and fetal grow retardation. Analgesic, antipyretic, especially anti-inflammatory activity occurs in high therapeutic doses. In low-dose acetylsalicylic acid is used to block production of thromboxane A2. Big epidemiological data suggest that low-dose of acetylsalicylic acid, even taken chronically, is safe for mother and fetus. However, animal and various human data have shown that high doses of the drug could produce different congenital malformations. The current literature suggests that acetylsalicylic acid should be given in pregnancy only if the potential benefit justifies the potential risk to the fetus. Anti-inflammatory doses should be stopped in the third trimester of gestation or given if the drug is needed in life-threatening situation or for serious disease for which safer drugs can not be used or are ineffective.

Abnormalities, Drug-Induced↗
PubMed1975

Dissolution of acetylsalicylic acid from acetylsalicylic acid-polyethylene glycol 6000 coprecipitates.

Investigation of possible enhancement of dissolution of acetylsalicylic acid via coprecipitation with polyethylene glycol 6000 was carried out. The results indicated that the initial amount of acetylsalicylic acid released from its coprecipitates or physical mixtures with polyethylene glycol 6000 was increased over that amount released from plain acetylsalicylic acid powder during the same period of time. This was attributed to lowering of the surface tension of the dissolution medium imparted by polyethylene glycol 6000. The effect of particle size of the coprecipitate on the dissolution rate of acetylsalicylic acid was also studied. Greater viscosity values produced by higher concentrations of polyethylene glycol 6000 in the coprecipitates appeared also to influence the dissolution rate of acetylsalicylic acid. The use of optimum concentration of polyethylene glycol 6000 in physical mixtures or coprecipitates would seem advantageous in the preparation of solid dosage forms containing acetylsalicylic acid.

Adjuvants, Pharmaceutic↗
PubMedDate not supplied

Simultaneous determination of ascorbic acid and acetylsalicylic acid in pharmaceutical formulations.

A direct, simple, and practical first-derivative spectrophotometric method is described for simultaneous determination of ascorbic acid and acetylsalicylic acid. The effects of the solvent, excipients, and spectral variables on the analytical signal were investigated. The drugs were determined simultaneously with a 0.01 M methanolic hydrochloric acid solution as the solvent, and the signals were evaluated directly by using the zero-crossing method at 245.0 and 256.0 nm for acetylsalicylic acid and ascorbic acid, respectively. The method allows the simultaneous determinations of acetylsalicylic acid and ascorbic acid in the ranges of 6.6 x 10(-6) to 1.5 x 10(-4)M and 3.4 x 10(-6) to 2.0 x 10(-4)M, respectively, with standard deviation of <2.0%. The proposed method was applied to determinations of these drugs in tablets.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed2003

Synergistic inhibitory effect of ascorbic acid and acetylsalicylic acid on prostaglandin E2 release in primary rat microglia.

Ascorbic acid (vitamin C) has been suggested to protect cerebral tissue in a variety of pathophysiological situations such as head trauma, ischemia or Alzheimer's disease. Most of these protective actions have been attributed to the antioxidative capacity of ascorbic acid. Besides the presence of elevated levels of oxygen radicals, prostaglandins produced by neurones and microglial cells seem to play an important role in prolonged tissue damage. We investigated whether ascorbic acid alone inhibits prostaglandin E2 (PGE2) synthesis and may augment the inhibitory effect of acetylsalicylic acid on prostaglandin synthesis. Ascorbic acid dose-dependently inhibited PGE2 synthesis in lipopolysaccharide-treated primary rat microglial cells (IC50 = 3.70 micro m). In combination with acetylsalicylic acid (IC50 = 1.85 micro m), ascorbic acid augmented the inhibitory effect of acetylsalicylic acid on PGE2 synthesis (IC50 = 0.25 micro m in combination with 100 micro m ascorbic acid). Ascorbic acid alone or in combination with acetylsalicylic acid did not inhibit cyclooxygenase-2 (COX-2) protein synthesis but inhibited COX-2 enzyme activity. Our results show that ascorbic acid and acetylsalicylic acid act synergistically in inhibiting PGE2 synthesis, which may help to explain a possible protective effect of ascorbic acid in various brain diseases.

Animals↗
PubMedDate not supplied

[Age-related characteristics of the pharmacokinetics of acetylsalicylic acid].

Acetylsalicylic acid pharmacokinetics was studied in young, elderly and old patients after a single oral administration in a dose of 14 mg/kg. The pharmacokinetics data may be formalized by means of the one-compartment model with absorption. Constants of absorption and elimination, total clearance value are decreased with age. The half-life in elderly patients was 6.19 hrs, in old patients 12.2 hrs and in young patients 4.47 hrs. In elderly and old patients the area under the pharmacokinetic curve increased. The ability of serum proteins to bind salicylates reduced during ageing. The pharmacokinetic model was used for optimization of treatment with acetylsalicylic acid of elderly and old patients.

Administration, Oral↗
PubMed1985

Acetylsalicylic acid compared with acetylsalicylic acid plus codeine as postoperative analgesics after removal of impacted mandibular third molars.

In a multicenter, double blind clinical trial a combination of acetylsalicylic acid 500 mg + codeine phosphate 30 mg has been compared with acetylsalicylic acid 500 mg as postoperative analgesics in patients with pain after surgical removal of impacted mandibular third molars. Evaluation of the results from 129 patients showed that the combination of acetylsalicylic acid and codeine provided better pain relief and also the number of tablets used was smaller and the time intervals between repeated doses were longer than with acetylsalicylic acid only. Adverse effects were few and similar for both drugs. It may be concluded that the combination of 500 mg acetylsalicylic acid and 30 mg codeine phosphate provides a useful analgesic for more severe pain conditions in oral surgery.

Adolescent↗