Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “ACETYLCHOLINE/antagonists”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMed1960

Evaluation of antagonists of histamine, 5-hydroxytryptamine and acetylcholine in the guinea-pig.

Changes in the resistance to entry of air into the lungs of anaesthetized guinea-pigs have been used to study the effects of histamine, 5-hydroxytryptamine, and acetylcholine. Some known antagonists of these bronchoconstrictor agents have been investigated. The degree of antagonism has been expressed in terms of the dose ratio, previously used only with in vitro preparations.

Acetylcholine↗
PubMed1960

Transmission failure in sympathetic nerves produced by hemicholinium.

It has been shown by others that hemicholinium (alpha,alpha'-dimethylethanolamino-4,4'-biacetophenone) inhibits the synthesis of acetylcholine, an effect which is reversed by choline. Hemicholinium produces a failure of response to nerve stimulation in the following sympathetically innervated preparations: guinea-pig isolated vas deferens, rabbit isolated uterus, rabbit isolated colon, perfused rabbit ear, cat isolated atria and the piloerector muscles in the cat's tail. The blocking action of hemicholinium on the responses to postganglionic sympathetic stimulation resembles its blocking action against cholinergic nerve stimulation observed on rabbit isolated atria with vagus nerves, rabbit isolated vagina with pelvic nerves, and guinea-pig isolated diaphragm with phrenic nerve. The failure of transmission produced by hemicholinium in sympathetic nerves and in cholinergic nerves can be reversed by choline. It is suggested that if there were a cholinergic junction at sympathetic nerve endings the mechanism of the blocking action of hemicholinium at these endings could be explained by inhibition of acetylcholine synthesis.

Acetylcholine↗
PubMed1962

Relationship between anti-acetylcholine and anti-Tremorine activity in anti-parkinsonian and related drugs.

The anti-acetylcholine potency of a number of anti-Parkinsonism drugs and related phenothiazine compounds was determined using the isolated guinea-pig ileum. The antagonism was assessed by the difference between the pA(2) and pA(10) values and by log concentration-response curves for acetylcholine in presence and absence of the antagonists. All compounds except chlorpromazine showed some evidence of competitive antagonism to acetylcholine. The anti-tremor potency of the compounds was assessed from suppression of Tremorine-induced tremors in mice. There was a relation between anti-acetylcholine and anti-Tremorine potency among the anti-Parkinsonism drugs, but not among the phenothiazine compounds. Some implications of the findings are discussed in relation to the mode of action of anti-Parkinsonism drugs.

Acetylcholine↗